Pharmacogenetics of Warfarin in a Diverse Patient Population.

Introduction: Many warfarin-related genotypes have shown to impact the average daily warfarin (ADW) dose requirements; however, information in non-Caucasian populations is limited.

Objectives: To identify the frequencies of 4 warfarin-related gene polymorphisms in an ethnically diverse patient population and to examine their impact with other clinical variables on ADW dose requirements.

Methods: Patients were recruited from 2 anticoagulation clinics in the Los Angeles area.