Publications by authors named "Lilia Proskurjakov"
ChemMedChem
December 2019
Article Synopsis
- The ubiquitin-proteasome system (UPS) is a key target for drugs that treat certain blood cancers, with current drug discovery focusing on compounds that bind to it permanently or semi-permanently.
- The study reports on enhancing the effectiveness of a class of compounds known as α-ketoamides, aiming to improve their cytotoxicity and target specificity for treating leukemia.
- The research indicates that modifying the α-ketoamide structure, particularly by adding a 3-phenoxy group, boosts its ability to inhibit the proteasome and shows promise for safer therapeutic options compared to existing treatments like bortezomib.
