Publications by authors named "Lilia Mercedes Sierra-Galan"

Article Synopsis
  • The MTHFR enzyme influences homocysteine levels, and genetic variants (polymorphisms) in its gene can alter its activity, potentially increasing the risk for thromboembolic diseases.
  • A study examined how the C677T and A1298C polymorphisms in the MTHFR gene relate to homocysteine levels and prothrombotic markers in patients with pulmonary embolism (PE) and acute myocardial ischemia (AMI).
  • Analyzing 334 patient records revealed that specific genotypes were significantly more common in those with thrombotic conditions, with elevated homocysteine levels associated with certain genetic alleles linked to increased risk of AMI and severe PE events.
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Systemic arterial hypertension is the prevalentest disease worldwide that significantly increases cardiovascular risk. An early diagnosis together to achieve goals decreases the risk of complications significatly. Recently have been updated the diagnostic criteria for hypertension and the introduction of ambulatory blood pressure monitoring.

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Systemic arterial hypertension (SAH) is one of the most common conditions seen in primary care of cardiovascular disease and whose consequences; depending on the "target organ" affecting produce ischemic heart disease, cerebral vascular disease or chronic kidney disease. In the pathogenesis of HAS are several physiopathological mechanisms involved; of which currently, to name the most important and frequent play a role in increasing adrenaline levels, the renin-angiotensin-aldosterone system and recently, much the participation of insulin resistance and hyperinsulinemia mentioned. These processes lead to an imbalance between the sympathetic and parasympathetic tone, coupled with hypersensitivity sodium trigger one of the pathophysiologic mechanisms of hypertension.

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