Publications by authors named "Lilia Belikova"
Astrocytes are subtypes of glial cells involved in metabolic, structural, homeostatic, and neuroprotective processes that help neurons maintain viability. Insulin-like growth factors IGF-1 and IGF-2 are known to have neuroprotective effects on neurons and glial cells through interaction with specific receptors. IGF forms a complex with IGF-binding proteins (IGFBP) in nervous tissue and is released from the complex via IGFBP proteolysis by specific proteases.
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- Pathogenic variants in the Gαo gene, crucial for brain function, are associated with severe neurological disorders, including developmental delays and epilepsy.
- A study utilized patient-derived induced pluripotent stem cells to investigate the effects of the p.G203R variant, discovering issues in cell development and differentiation into neurons, characterized by abnormal gene expression.
- Functional tests revealed that neurons with the p.G203R mutation exhibited lower calcium levels, reduced activity, and impaired responses to neurotransmitters, indicating a significant impact on brain signaling and development.
Article Synopsis
- * The study investigated calcium signaling in GABA-ergic medium spiny neurons derived from iPSCs created through different methods (lentivirus and Sendai virus) from the same donor's fibroblasts.
- * Results showed no significant differences in calcium signaling between neurons from both reprogramming methods, indicating compatibility for combining data from different iPSC models and enhancing biobanking potential.
The iPSC-derived brain organoid is a promising technology for in vitro modeling the pathologies of the nervous system and drug screening. This technology has emerged recently. It is still in its infancy and has some limitations unsolved yet.
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