Publications by authors named "Lili Yu"

Background: Safflower thrives in dry environments but faces difficulties with flowering in wet and rainy summers. Flavonoids play a role in flower development and can potentially alleviate these challenges. Furthermore, the FLOWERING LOCUS T (FT) family of phosphatidylethanolamine-binding protein (PEBP) genes play a crucial role in the photoperiodic flowering pathway.

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Background: Cellular senescence is a key driver of decreased bone formation and osteoporosis. Leptin (LEP) has been implicated in cellular senescence and osteogenic differentiation. The aim of this study was to investigate the mechanisms by which LEP mediates cellular senescence and osteogenic differentiation.

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Lung adenocarcinoma (LUAD) is one of the deadliest cancers. Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-targeted therapy is an important approach for treating LUAD. However, the development of acquired resistance poses a serious clinical challenge.

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β-Carboline alkaloids are a broad class of indole alkaloids that were first isolated from Peganum harmala L., a traditional Chinese herbal remedy. β-Carboline alkaloids have been found to have many pharmacological activities, including anti-inflammatory, antioxidant, and anti-cancer properties.

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Independent censoring is usually assumed in survival data analysis. However, dependent censoring, where the survival time is dependent on the censoring time, is often seen in real data applications. In this project, we model the vector of survival time and censoring time marginally through semiparametric heteroscedastic accelerated failure time models and model their association by the vector of errors in the model.

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Safflower ( L.) is a traditional Chinese medicinal herb renowned for its high flavonoid content and significant medicinal value. However, the dynamic changes in safflower petal flavonoid profiles across different flowering phases present a challenge in optimizing harvest timing and medicinal use.

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Article Synopsis
  • * Antiviral therapies are the main treatment options for HSV-1, and promising vaccine developments include live attenuated, protein subunit, and nucleic acid vaccines that aim to prevent infections.
  • * The virus can also be modified for therapeutic uses, such as in gene therapy and cancer immunotherapy, making it a versatile subject for research and medical applications.
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Letter position coding has been extensively examined in studies of isolated word identification, spurring the development of computational models. However, these models are largely restricted to explaining word identification in foveal vision, despite the fact that early lexical processing during reading occurs in the parafovea. We report four experiments that examined the flexibility of parafoveal letter identity and position coding using a variant of the same-different match task.

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Psoriasis and inflammatory bowel disease (IBD) are chronic immune-mediated diseases that adversely affect patients' quality of life. Interleukin (IL)-27 plays an important role in a variety of infectious diseases, autoimmune disorders, and cancers. However, its therapeutic effects in psoriasis and colitis remain underexplored.

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In the realm of medical diagnostic testing, diagnostic tests can assume either binary forms, distinguishing between diseased and non-diseased states, or ordinal forms, categorizing states from non-diseased to various stages (1 to K). Another significant classification scheme for multi-class scenarios is tree or umbrella ordering, which entails several unordered sub-classes (subtypes) within a biomarker. Within tree or umbrella ordering, the classifier assesses whether the marker measurement for one class surpasses or falls below those for the other classes.

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  • Macao's first COVID-19 case was reported in January 2020, leading to a recruitment effort for healthcare workers (HCWs) in private sectors by August 2021 due to escalating community transmission and concerns for personal and public health.
  • The study aimed to investigate the impact of the pandemic on sleep quality and psychological well-being of HCWs in Macao, using various assessment tools from December 2020 to January 2022.
  • Results showed that around 32% experienced sleep disorders and over 50% faced depression, with no significant change between two surveys, indicating a consistent negative impact of COVID-19 on HCWs' mental health and sleep quality.
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This study summarizes the significance of microRNA-134 (miRNA-134) in the pathophysiology, diagnosis, and treatment of depression, a disease still under investigation due to its complexity. miRNA-134 is an endogenous short non-coding RNA that can bind to the 3' untranslated region (3'UTR) of miRNA-134, inhibiting gene translation and showing great potential in the regulation of mood, synaptic plasticity, and neuronal function. This study included 15 articles retrieved from four English-language databases: PubMed, Embase, The Cochrane Library, and Web of Science, and three Chinese literature databases: CNKI, Wanfang, and Chinese Science and Technology Periodical Database (VIP).

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Unlabelled: Limited information exists on age and racial disparities in sleep duration and mortality in the United States (US) population. This study compared the association between mortality and sleep duration within distinct races and age groups in the US. This study used data on 26,915 US citizens (≥ 18 years) from the 2004 wave of the National Health Interview Survey, linked to the National Death Index prospective mortality through 2019.

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Renal fibrosis (RF) is a common endpoint of various chronic kidney diseases, leading to functional impairment and ultimately progressing to end-stage renal failure. Glycolytic reprogramming plays a critical role in the pathogenesis of fibrosis, which maybe a potential therapeutic target for treating renal fibrosis. Here, we revealed the novel role of ZEB1 in renal fibrosis, and whether targeting ZEB1 is the underlying mechanism for the anti-fibrotic effects of ethyl caffeate (EC) to regulate the glycolytic process.

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Article Synopsis
  • - Psoriasis is a chronic skin condition linked to immune system dysfunction and oxidative stress, with the neonatal Fc receptor (FcRn) playing a potential role in its severity according to clinical analyses.
  • - In a mouse model of psoriasis, researchers found lower levels of FcRn in affected skin, and the ferroptosis pathway was activated, suggesting that FcRn may influence this process through the STAT3/SLC7A11 signaling pathway.
  • - Experiments indicated that depleting FcRn increased psoriatic lesions and ferroptosis, while inhibiting this process or activating FcRn improved symptoms, pointing to possible new treatments for psoriasis.
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Elevated production of extracellular matrix (ECM) in tumor stroma is a critical obstacle for drug penetration. Here we demonstrate that ATP-citrate lyase (ACLY) is significantly upregulated in cancer-associated fibroblasts (CAFs) to produce tumor ECM. Using a self-assembling nanoparticle-design approach, a carrier-free nanoagent (CFNA) is fabricated by simply assembling NDI-091143, a specific ACLY inhibitor, and doxorubicin (DOX) or paclitaxel (PTX), the first-line chemotherapeutic drug, via multiple noncovalent interactions.

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  • Herpes simplex virus type 1 (HSV-1) is linked to serious health issues including viral encephalitis and neonatal infections, prompting the exploration of vaccines for prevention.
  • Researchers created a genetically modified strain of Lactococcus lactis (NZ3900-gD-IL-2-Fc) to express a protective viral antigen, aiming to enhance immune responses.
  • Their findings showed that this recombinant vaccine significantly increased the production of antibodies and immune cell activity in mice, suggesting its potential effectiveness against HSV-1 infection.
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The Chinese writing system has several features that make it markedly different from the alphabetic systems that have most often been examined in reading research, including the fact that individual words consist of various uniformly sized, box-shaped characters whose boundaries are not clearly demarcated (e.g., by blank spaces).

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Four rhodamine 6G-PAH probes with pyrene (R6G-Pyr), anthracene (R6G-Ant), acenaphthene (R6G-Acp) or phenanthrene (R6G-PA) as fluorophore were designed and synthesized for Hg(II) detection. Probe R6G-PA, which had the lowest detection limit of 0.84 nmol/L, displayed the best fluorescence performance as compared to the other three probes.

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Objective: To investigate potential mechanisms of anti-atherosclerosis by berberine (BBR) using ApoE mice.

Methods: Eight 8-week-old C57BL/6J mice were used as a blank control group (normal), and 56 8-week-old AopE mice were fed a high-fat diet for 12 weeks, according to a completely random method, and were divided into the model group, BBR low-dose group (50 mg/kg, BBRL), BBR medium-dose group (100 mg/kg, BBRM), BBR high-dose group (150 mg/kg, BBRH), BBR+nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor group (100 mg/kg BBR+30 mg/kg ML385, BBRM+ML385), NRF2 inhibitor group (30 mg/kg, ML385), and positive control group (2.5 mg/kg, atorvastatin), 8 in each group.

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Over the past decade, the attrition rate of Chinese medical graduates has remained high, and the COVID-19 pandemic has exacerbated this situation. Medicine specialty students are the main force of the future healthcare industry. The career choices and career confidence of those entering the healthcare industry will have a huge influence on the quality of future healthcare provision.

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  • A study was conducted to evaluate the effectiveness of serum fibrin degradation complex DR-70 in diagnosing colorectal cancer (CRC) alongside traditional tumor markers, as early symptoms are often absent.
  • Researchers analyzed serum samples from patients with CRC, benign colorectal diseases, and healthy individuals, measuring the levels of DR-70 and other tumor markers.
  • Results showed that DR-70 levels varied significantly between groups, making it a promising diagnostic tool with high sensitivity, which could enhance CRC detection when used with existing markers.
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Background: Herpes zoster is an infectious skin disease caused by the reactivation of the varicella zoster virus (VZV), which has been latent in the posterior root ganglia of the spinal cord or cranial ganglia for an extended period. Neurological complications caused by herpes zoster include aseptic meningitis, white matter disease, peripheral motor neuropathy, and Guillain-Barré syndrome. However, reduced unilateral sweating caused by the VZV is very rare.

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Background: Hepatocellular carcinoma (HCC) is the most common malignant liver disease in the world. Platelets (PLTs) are known to play a key role in the maintenance of liver homeostasis and the pathophysiological processes of a variety of liver diseases. Aspirin is the most classic antiplatelet agent.

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