Organic dyes are extensively used in industries such as textiles and printing, contributing to the increasing discharge of wastewater and posing significant risks to human health. Conventional photocatalysts, including metal oxides and sulfides, often exhibit limited pollutant adsorption capacities and suffer from charge carrier recombination. In this study, we synthesized a novel composite aerogel via the lyophilization of cellulose modified with polyethyleneimine and cadmium sulfide.
View Article and Find Full Text PDFBackground: The associations of gut microbial metabolites, such as trimethylamine N-oxide (TMAO), its precursors, and phenylacetylglutamine (PAGln), with the risk of gestational diabetes mellitus (GDM) remain unclear.
Methods: Serum samples of 201 women with GDM and 201 matched controls were collected and then targeted metabolomics was performed to examine the metabolites of interest. Multivariable conditional logistic regression was applied to investigate the relationship between metabolites and GDM.
Perfluorooctane sulfonates (PFOS) are the persistent organic pollutants. In the present study, 0, 0.3, or 3-mg/kg PFOS were administered to pregnant mice from GD 11 to GD 18.
View Article and Find Full Text PDFJ Environ Sci Health A Tox Hazard Subst Environ Eng
April 2024
PM is an important risk factor for the development and progression of cognitive impairment-related diseases. Ferroptosis, a new form of cell death driven by iron overload and lipid peroxidation, is proposed to have significant implications. To verify the possible role of ferroptosis in PM-induced neurotoxicity, we investigated the cytotoxicity, intracellular iron content, iron metabolism-related genes, oxidative stress indices and indicators involving in Nrf2 and ferroptosis signaling pathways.
View Article and Find Full Text PDFThe surge in economic growth has spurred the expansion of the textile industry, resulting in a continuous rise in the discharge of printing and dyeing wastewater. In contrast, the photocatalytic method harnesses light energy to degrade pollutants, boasting low energy consumption and high efficiency. Nevertheless, traditional photocatalysts suffer from limited light responsiveness, inadequate adsorption capabilities, susceptibility to agglomeration, and hydrophilicity, thereby curtailing their practical utility.
View Article and Find Full Text PDFBackgrouds: As a human carcinogen, radon and its progeny are the second most important risk factor for lung cancer after smoking. The tumor suppressor gene, , is reported to play an important role in the maintenance of mitochondrial function. In this work, we investigated the association between p53 and p53-responsive signaling pathways and radon-induced carcinogenesis.
View Article and Find Full Text PDFDyeing wastewater is a carcinogenic pollutant, which is widely known for its harmful effects on humans and marine organisms. In this study, a novel composite was prepared by blending thiourea modified chitosan with zinc sulfide nanoparticles (T-CS/ZnS) to comprehensively remove methyl orange (MO), rhodamine B (Rh B), and methylene blue (MB) effectively. Characterization results suggested that the synthesized composite has an irregular and rough surface that provided high specific surface area for adsorption process, while the strong optical response and low bandgap width contributed to the subsequent photocatalytic degradation of adsorbed dye molecules.
View Article and Find Full Text PDFPhotocatalysis has been widely used for the removal of hexavalent chromium from wastewater as an efficient and environmental friendly method. However, conventional photocatalysts generally exhibit poor adsorption properties toward Cr(VI), resulting in unsatisfactory performance in high concentrated wastewaters. In this study, we synthesized a novel composite material with high Cr(VI) adsorption ability by blending prepared CuS nanocrystals into triethylenetetramine modified sodium alginate for the enhanced photocatalytic removal of Cr(VI).
View Article and Find Full Text PDFSilver nanoparticles (AgNPs) are widely used in a variety of consumer products because of their antibacterial and antifungal characteristics, but little is known about their toxicity to the brain. In this study, we investigated AgNP-induced neurotoxicity using the human neuroblastoma cancer (SH-SY5Y) cell line. After a 24 h treatment of AgNPs with two primary sizes (5 and 50 nm labeled as Ag-5 and Ag-50, respectively), a series of toxicological endpoints including cell viability, expression of proteins and genes in amyloid precursor protein (APP) amyloid hydrolysis process and ferritinophagy signaling pathways, oxidative stress, intracellular iron levels, and molecular regulators of iron metabolism were evaluated.
View Article and Find Full Text PDFBackground: Fine particulate matter (PM) is a ubiquitous air pollutant, and it has been reported to be closely associated with lung inflammatory injury. In this study, the potential molecular mechanisms underlying PM-induced cellular inflammation in human bronchial epithelial (BEAS-2B) cells were investigated.
Materials And Methods: Ambient PM particulates from Suzhou, China, were collected and re-suspended in ultrapure water.
This study aimed to investigate the potential molecular mechanism underlying radon-induced lung damage. Our results showed that long-term radon exposure induced mitochondrial damage and redox imbalance in BEAS-2B cells and a time-dependent lung pathological injury in mice. The activation of Nrf-2 and its down-stream antioxidants, and the gene expression of the indicated markers at different stages of autophagy were found to be induced with the increasing of radon exposure time.
View Article and Find Full Text PDFScope: It remains unclear whether dietary advanced glycation end products (dAGEs)-induced cognitive impairment is sex-dependent. Trehalose may antagonize dAGEs-induced neurotoxicity via glycogen synthase kinase-3 beta (GSK3β)-transcription factor EB (TFEB) signaling.
Methods And Results: The sex-specific neurotoxicity of dAGEs and the protective role of trehalose are investigated both in vivo and in vitro.
Background And Aims: Visceral adipose index (VAI) had been widely used to predict the risks of several diseases. However, few studies have clarified the association between VAI and the risk of hypertension in Chinese population. Thus, we investigate the association between VAI and the increased risk of hypertension in a nationwide cohort of middle-aged and elderly adults in China.
View Article and Find Full Text PDFThe widespread use of silver nanoparticles (AgNPs), their many sources for human exposure, and the ability of AgNPs to enter organisms and induce general toxicological responses have raised concerns regarding their public health and environmental safety. To elucidate the differential toxic effects of polyvinylpyrrolidone-capped AgNPs with different primary particle sizes (i.e.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2021
Exposure to PM can cause adverse health outcomes. In this study, we analyzed PM samples collected from suburban and urban sites, including a traffic tunnel in Suzhou, China, for their physicochemical properties, endotoxin contents, and effects on HepG2 and A549 cells in vitro. The greatest cellular responses, including oxidative stress, cytotoxicity, genotoxicity, inflammatory, and transcriptional activation of stress-responsive genes (i.
View Article and Find Full Text PDFZhongguo Yi Liao Qi Xie Za Zhi
January 2019
Because the translation hypothesis of optical flow method can not accurately describe the form of motion after tissue compression, so we proposed a new ultrasonic elastic imaging algorithm. It was assumed that the deformation of the tissue was affine transformation when the probe was pressed to the tissue, and the displacement and strain distribution were estimated simultaneously by the optical flow method combined with the prior estimation. In order to verify the effectiveness of the algorithm, the imaging quality of the algorithm and the other imaging algorithm were compared with the simulated radio frequency echo signal.
View Article and Find Full Text PDFVitamin D is reported to be involved in the regulation of inflammatory processes. In this study, biomarkers related to oxidative stress and inflammation were investigated to clarify the protective effects and possible mechanism of 1,25-dihydroxy vitamin D (1,25-(OH)D) on PM-induced inflammatory response. In the in vitro study using human bronchial epithelial (HBE) cells, aqueous extracts of PM could induce oxidative damage which is characterized by significant increases in production of reactive oxygen species, malonaldehyde concentration, and protein expression of HSPA1A and HO-1.
View Article and Find Full Text PDFAlthough many studies have investigated the association of single nucleotide polymorphisms (SNPs) in transforming growth factor beta1 (TGF-β1) gene with pulmonary fibrosis (PF), but their association is still controversial. To clarify this, we performed a meta-analysis.Studies related to TGF-β1 and PF were retrieved from PubMed, Medline, Embase, Scopus, and Wanfang (up to November 30, 2017).
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
October 2016
To systematically review the efficacy and safety of Danhong injection for patients with idiopathic pulmonary fibrosis(IPF), two researchers electronically searched PubMed, EMbase, Web of Science, Cochrane Library, CNKI, CBM, WanFang Data and VIP databases from the date of establishment to May 2016 for all randomized controlled trials(RCTs) and quasi-RCTs on the use of Danhong injection in patients with IPF. Manual search in relevant journals and search of relevant literature on other websites were also performed. The data extraction and quality assessment of included RCTs and quasi-RCT were conducted by two reviewers independently.
View Article and Find Full Text PDFObjectives: The intense commercial application of silver nanoparticles (AgNPs) has been raising concerns about their potential adverse health effects to human. This study aimed to explore the potency of AgNPs to induce GADD45α gene, an important stress sensor, and its relationships with the cytotoxicity and genotoxicity elicited by AgNPs.
Methods: Two established HepG2 and A549 cell lines containing the GADD45α promoter-driven luciferase reporter were treated with increasing concentrations of AgNPs for 48 hours.
The use of silver nanoparticles (AgNPs) in consumer products and medical applications is growing rapidly owing to their noted antimicrobial properties. As a consequence, a rapid and reliable toxicology test that allows multiple nanosilver screening in a stress responsive pathway-based assay is needed to ensure consumer safety. Here, novel promoter-driven luciferase reporter gene assays based on two cell models widely used in toxicology testing, HepG2 and A549 cell lines, were developed to analyze the oxidative stress elicited by AgNPs.
View Article and Find Full Text PDFThe exponential increase in the total number of engineered nanoparticles in consumer products requires novel tools for rapid and cost-effective toxicology screening. In order to assess the oxidative damage induced by nanoparticles, toxicity test systems based on a human HSPA1A promoter-driven luciferase reporter in HepG2, LO2, A549, and HBE cells were established. After treated with heat shock and a group of silver nanoparticles (AgNPs) with different primary particle sizes, the cell viability, oxidative damage, and luciferase activity were determined.
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