In genomic study, log transformation is a common prepossessing step to adjust for skewness in data. This standard approach often assumes that log-transformed data is normally distributed, and two sample t-test (or its modifications) is used for detecting differences between two experimental conditions. However, recently it was shown that two sample t-test can lead to exaggerated false positives, and the Wilcoxon-Mann-Whitney (WMW) test was proposed as an alternative for studies with larger sample sizes.
View Article and Find Full Text PDFOur current understanding of how linguistic concepts are represented and retrieved in the brain is largely based on studies using concrete language, and only few studies have focused on the neural correlates of abstract concepts. The role of the motor system, besides the classical language network, has been intensively discussed in action-related concrete concepts. To advance our understanding of spatiotemporal dynamics underlying abstract concept processing, our study investigated to what extent language and motor regions are engaged in the processing of abstract concepts vs.
View Article and Find Full Text PDFThe topics of psychological maltreatment by teachers and children's cyberbullying perpetration have both attracted increasing research attention. However, clarification of the development and specific psychological mechanisms linking psychological maltreatment by teachers to cyberbullying perpetration by students remains necessary. Thus, this study examined the longitudinal relations between psychological maltreatment by teachers and subsequent cyberbullying perpetration, along with the mediating role of self-esteem and the moderating role of sex.
View Article and Find Full Text PDFBackground: Childhood maltreatment is a risk factor for internalizing and externalizing symptoms in early adolescents. However, few studies have examined the associations between profiles of childhood maltreatment and trajectories of internalizing and externalizing symptoms in Chinese early adolescents.
Objectives: First, this study aimed to identify profiles of childhood maltreatment (i.
This study examined three models (relationship-driven model, symptom-driven model and transactional model) testing the across-time bidirectional relations between psychological maltreatment by teachers and early adolescents' psychosocial adjustment (i.e., internalizing problems, externalizing problems, and academic achievement) during early adolescence.
View Article and Find Full Text PDFUnlabelled: The preschool years are a critical period for developing cognitive abilities such as reasoning, memorization, comprehension, quick thinking, and problem-solving. Sedentary behavior (SB) is known to be associated with cognitive development in preschool children. However, limited research has focused on how different types of SB (active, passive) and sedentary patterns (bouts, breaks) affect preschool children's cognitive abilities.
View Article and Find Full Text PDFBackground: An association between increased aortic root dimensions (ARD) and elevated risk of cardiovascular mortality has been reported in the general population. However, evidence regarding the association between ARD and mortality in patients with acute heart failure (AHF) is limited.
Methods: In a nationwide prospective cohort of the China Patient-Centered Evaluative Assessment of Cardiac Events Prospective Heart Failure Study, ARD was measured during diastole using echocardiography and indexed to body mass index (BMI).
Background: Patient-specific computer simulation of transcatheter aortic valve implantation (TAVI) predicts the interaction between an implanted device and the surrounding anatomy. In this study, we validated the predictive value of computer simulation for the frame deformation following a Venus-A TAVI implant in patients with pure aortic regurgitation (AR). Furthermore, we used the validated computational model to evaluate the anchoring mechanism within the same cohort.
View Article and Find Full Text PDFMorphine has been suggested to affect cancer cell dynamics and decrease survival rates in lung cancer patients at specific doses, but the precise mechanisms poorly understood. In this study, we aimed to investigate the molecular mechanisms by which morphine modulates the malignant characteristics of non-small cell lung cancer. Cell proliferation was assessed via the Cell Counting Kit-8 assay, and cell migration and invasion were examined via wound healing and Transwell assays.
View Article and Find Full Text PDFCarbon/Oxygen logging is an effective method to perform oil layer recognition and oil saturation calculation, which plays an important role in the evaluation of remaining oil after casing. At present, there are two main methods to calculate the ratio of carbon to oxygen (C/O). Compared with the energy window count method, the element yield method can avoid the influence of background count in the gamma spectrum and calculated carbon/oxygen value has the higher sensitivity and better accuracy, but it is still greatly affected by carbon and oxygen elements in the formation skeleton.
View Article and Find Full Text PDFBackground: This study aimed to identify the developmental trajectories of loneliness in Chinese children and examine the predictive roles of domain-specific environmental factors (i.e., family dysfunction and satisfaction of relatedness needs at school), personality factors (i.
View Article and Find Full Text PDFObjective: To investigate the role of curcumin in the treatment of lupus nephritis (LN) by inhibiting the migration of neutrophils and the underlying mechanism involved.
Methods: Two lupus mouse models, MRL/lpr mice and R848-treated mice, were treated with 50 mg/kg curcumin by intraperitoneal injection. H&E and Masson staining were used to estimate histopathological changes in the kidney.
In the context of China's garbage classification policy, on-site aerobic food waste (FW) digestion is crucial for reducing transportation and disposal costs. The efficiency of this process is largely determined by the microbial community structure and its functions. Therefore, this study aimed to analyze the impact of a personalized microbial consortium (MCM) on the efficiency of aerobic FW digestion and to reveal the underlying mechanisms.
View Article and Find Full Text PDFIn practice, we often encounter binary classification problems where both main classes consist of multiple subclasses. For example, in an ovarian cancer study where biomarkers were evaluated for their accuracy of distinguishing noncancer cases from cancer cases, the noncancer class consists of healthy subjects and benign cases, while the cancer class consists of subjects at both early and late stages. This article aims to provide a large number of optimal cut-point selection methods for such setting.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is a chronic autoimmune disease in which multiple organs are damaged that prevails in fertile women. Currently, glucocorticoids and immunosuppressants are widely used to treat SLE patients. However, ovarian dysfunction occurs following the use of these drugs in women with SLE.
View Article and Find Full Text PDFChronic hepatitis E mostly occurs in organ transplant recipients and can lead to rapid liver fibrosis and cirrhosis. Previous studies found that the development of chronic hepatitis E virus (HEV) infection is linked to the type of immunosuppressant used. Animal models are crucial for the study of pathogenesis of chronic hepatitis E.
View Article and Find Full Text PDFCompetency-based teasing has been identified as a risk factor for children's depressive symptoms. However, the specific psychological mechanisms mediating this relationship are not well understood, especially in the context of Chinese culture. This study examined the relationship between competency-based teasing, subsequent depressive symptoms, and the possible mediating role of positivity in Chinese children by using parallel process latent growth curve modelling.
View Article and Find Full Text PDFBackground: The monkeypox virus (MPXV) is a linear double-stranded DNA virus with a large genome that causes tens of thousands of infections and hundreds of deaths in at least 40 countries and regions worldwide. Therefore, timely and accurate diagnostic testing could be an important measure to prevent the ongoing spread of MPXV and widespread epidemics.
Results: Here, we designed multiple sets of primers for the target region of MPXV for loop-mediated isothermal amplification (LAMP) detection and identified the optimal primer set.
Background: Psychological maltreatment by teachers and peer victimization are significant public health issues among youth. However, few studies have verified transactional associations between psychological maltreatment by teachers and peer victimization at the within-person level and the mediating roles of depression and aggression have yet to be fully evaluated.
Objective: This study examined the transactional associations between psychological maltreatment by teachers and peer victimization from middle childhood to early adolescence, separating within- and between-person variation.