Organogel Polymer Electrocatalysts for Two-Electron Oxygen Reduction.

Polymer gels, renowned for unparalleled chemical stability and self-sustaining properties, have garnered significant attention in electrocatalysis. Notably, organic polymer gels that exhibit temperature sensitivity and incorporate suitable polar nonvolatile liquids, enhance electronic conductivity, and impart distinct morphological features, but remain largely unexplored as electrocatalysts for oxygen reduction reaction (ORR). To address this issue, an innovative strategy is proposed for synergistic modulation of the rigidity of mainchain molecular skeleton and length of alkyl sidechains, enabling the development of organogel polymers with a sol-gel temperature-sensitive phase transition that promises high selectivity and enhanced activity in electrocatalytic processes.

Analysis of urban-rural differences in the relationship between grandparenting and the nutrition and health status of children aged 0-3 in China.

Background: The practice of grandparents taking on the role of primary caregivers for their grandchildren is widespread across both urban and rural regions in China. Yet, the existing body of research offered limited clarity on how grandparenting associated with nutrition as well as health of children aged 0-3 years, particularly in terms of potential differences between urban and rural areas in China. Therefore, this study aims to delve into the association between grandparenting and nutrition as well as health status of children aged 0-3 and its urban-rural differences in China.

The Evolution of Mechanical Properties and Cellular Structure of Apples During Freeze Drying Combined with Hot Air Drying (FD-HAD) Process.

Apples are one of the most popular fruits in the world and have a significant share in domestic and international fruit production. Drying is a common method used to extend the shelf life of apples. However, it also induces irregular morphological changes in apples, which are essential to maintaining the structural integrity of the material.

Increased perfluorooctanoic acid accumulation facilitates the migration and invasion of lung cancer cells via remodeling cell mechanics.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in industrial and household products, raising serious concerns due to their environmental persistence and mobility. Epidemiological studies have reported potential carcinogenic risks of PFAS based on their widespread occurrence and population exposure. In this study, we observed that perfluorooctanoic acid (PFOA), a common PFAS, functions as a mechanical regulator in lung cancer cells.

A pilot study of tofacitinib citrate with 308-nm excimer laser for the treatment of vitiligo.

Background: Vitiligo is a clinically prevalent acquired skin disorder characterized by depigmentation. Currently, the therapeutic options for vitiligo are restricted, and numerous issues exist, such as a prolonged treatment course, unsatisfactory therapeutic efficacy, adverse reactions, and a high propensity for recurrence after treatment cessation.

Aim: To assess the safety and efficacy of combined treatment involving oral tofacitinib citrate (TC) and a 308-nm excimer laser (EL), with the aim of discovering a rapid and effective treatment approach to minimize the side effects of various drugs.

Peptide-Induced Hydrogelation with Ordered Metal-Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair.

Hydrogels, with their high water content and flexible nature, are a promising class of medical dressings for combating bacterial wound infections. However, their development has been hindered by low sterilization efficiency. Here, this issue is addressed by designing a peptide hydrogel that assembles ordered metal-organic framework (MOF) nanoparticles with photocatalytic bactericidal activity.

LncRNA AP001007 protects human renal tubular epithelial HK-2 cells and kidney organoids from LPS-induced injury.

The regulation of long non-coding RNAs (lncRNAs) has been implicated in the pathogenesis of sepsis-induced acute kidney injury (SI-AKI). Nevertheless, the specific roles of individual lncRNAs in this process remain unclear. This study investigated the expression of lncRNA AP001007 in lipopolysaccharide (LPS)-induced HK-2 cells and in the peripheral blood of sepsis patients.

STAP2 promotes the progression of renal fibrosis via HSP27.

Background: Renal fibrosis is a key process in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD), while the intricate mechanisms of renal fibrosis remain obscure. While the signal-transducing adaptor protein 2 (STAP2) was well-studied for its notable function in inflammation and immune-related disorders, its specific implication in renal fibrosis remains unclear. This study assessed the mechanism by which STAP2 could promote the progression of renal fibrosis.

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1.

Sodium Danshensu (SDSS) is extracted from and has many pharmacological effects. However, little is known about its effects on muscle fiber formation and metabolism. Here, we aimed to investigated the role and molecular mechanisms of SDSS in modulating the formation of skeletal muscle fiber.

Clinical pharmacokinetics and pharmacodynamics of ongericimab: A potential long-acting PCSK9 monoclonal antibody in healthy subjects and patients with hypercholesterolemia: Randomized, double-blind, placebo-controlled phase Ia and Ib/II studies.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein-cholesterol (LDL-C) by decreasing the expression of the LDL-receptor on hepatic cells. Ongericimab (JS002) is a novel PCSK9 monoclonal antibody that exhibits a long-acting LDL-C lowering effect by exclusively inhibiting PCSK9 in pre-clinical studies. Two randomized, double-blind, placebo-controlled trials were conducted to evaluate the safety, tolerability, efficacy, immunogenicity, pharmacokinetic, and pharmacodynamic profiles of ongericimab in healthy subjects and patients with hypercholesterolemia.

Double-layer event-triggered policy of passivity-based output regulation under deception attacks for switched systems.

The problem of secure output regulation (SOR) is solved from the passivity viewpoint for the networked switched system (NSS) permitting severely unstable dynamics in the presence of deception attacks (DAs). Dual Double-layer event-triggered policies (DLETPs) are developed to govern the appropriate triggering in a layered manner in conjunction with parameters of passivity, DAs, and switching characteristics. A tolerant switching strategy (TSS) is proposed to permit destabilizing switching outnumbers stabilizing switching and capture the passivity parameter.

Host-guest-induced electronic state triggers two-electron oxygen reduction electrocatalysis.

Supramolecular polymers possess great potential in catalysis owing to their distinctive molecular recognition and dynamic crosslinking features. However, investigating supramolecular electrocatalysts with high efficiency in oxygen reduction reaction to hydrogen peroxide (ORHP) remains an unexplored frontier. Herein, we present organic polymers for ORHP by introducing cyclodextrin-containing noncovalent building blocks, affording these supramolecules with abundant dynamic bonds.

Smartwatch measurement of blood oxygen saturation for predicting acute mountain sickness: Diagnostic accuracy and reliability.

Objective: This study aims to assess the accuracy and stability of smartwatches in predicting acute mountain sickness (AMS).

Methods: In locations exceeding an altitude of 2500 m, a cohort of 42 subjects had their Lake Louise AMS self-assessment score, blood oxygen saturation (SpO), heart rate, and perfusion index measured using smartwatches, with the data seamlessly conveyed to the Huawei Cloud.

Results: A significant decrease in SpO was observed in individuals positive for AMS compared to those negative (< 0.