Stable Cobalt-Zeolite Propane-Dehydrogenation Catalysts Enabled by Reaction-Driven Reconstruction.

Cobalt-based catalysts have emerged as promising substitutes for Pt- and Cr-based propane dehydrogenation (PDH) catalysts. However, controlling the distribution of Co species and achieving stable active centers remains challenging. Here, we report that reaction-driven reconstruction of metallic cobalt (Co0) species within pure silica MFI zeolite (S-1) into CoOx clusters within silanol nests during PDH yields efficient and durable performance.

Artificial intelligence assisted identification of newborn auricular deformities via smartphone application.

Background: Auricular deformities are common in newborns and require early diagnosis and timely intervention. Several factors highlight the necessity of a machine learning-based diagnostic solution: the high prevalence of these conditions, the narrow time window for effective non-surgical treatment, limited medical resources, and the importance of both physical and mental well-being. This study presents a novel artificial intelligence (AI) model to identify and classify common sub-types of auricle deformities, using photos taken with mobile devices.

Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030.

Background: Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of Colorectal cancer cases and deaths can be attributed to modifiable risk factors, with smoking, alcohol use, and high body mass index (BMI) being the three most prominent. However, the impact of these risk factors on Colorectal cancer across regions, genders, and age groups remains insufficiently characterized.

Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds.

The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to resistance against multiple coronavirus disease 2019 (COVID-19) vaccines and therapeutic medications, making the development of effective therapeutics against SARS-CoV-2 a high priority. Studies have shown that bioactive polyphenols, particularly those with triphenol groups, can effectively inhibit the activity of SARS-CoV-2 3-chymotrypsin-like protease (3CL). However, the structural instability of polyphenols necessitates further research.

MOF-Derived N-Doped Carbon Nanotube-Confined Ni Nanoparticles for the Simultaneous Electrochemical Detection of Cu²⁺ and Hg²⁺ with High Sensitivity and Stability.

Heavy metal pollution has posed a serious threat to the ecological environment and human health. Thus, the development of accurate and effective methods for their detection is crucial. In this study, a novel electrochemical sensor was fabricated to detect Cu and Hg, based on N-doped carbon nanotube-wrapped Ni nanoparticle (Ni@N-CNT) sensing material, which was derived from the pyrolysis of Ni doped ZIF-8.

WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer.

Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting in unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein 1 (WBP1) affects mitochondrial function, cell growth, ferroptosis, and chemoresistance in CRC cells.

AIE luminogens based on 9, 10-dithienylanthracene with a D-A-D structure: Design, synthesis and application in cell imaging.

Three novel D-A-D-structured emitters derived from 9, 10-dithienylanthracene derivatives (DTAs) were synthesized and characterized. These DTAs consist of substituted 9-phenyl-9H-carbazole (BPCB-DTA), triphenylamine (BTPA-DTA) and N, N-dimethylaniline (BDMA-DTA) as donor units, with the phenylacetonitrile group serving as the acceptor. The impact of steric hindrance and electronic effect of the substituents on the optical properties has been thoroughly discussed.

Exponential stability of infinite-dimensional impulsive stochastic systems with Poisson jumps under aperiodically intermittent control.

This paper studies the problem of mean square exponential stability (ES) for a class of impulsive stochastic infinite-dimensional systems with Poisson jumps (ISIDSP) using aperiodically intermittent control (AIC). It provides a detailed analysis of impulsive disturbances, and the related inequalities are given for the two cases when the impulse perturbation occurs at the start time points of the control and rest intervals or non-startpoints, respectively. Additionally, in virtue of Yosida approximating systems, combining with the Lyapunov method, graph theory and the above inequalities, criteria for ES of the above impulsive stochastic infinite-dimensional systems are established under AIC for these two perturbation scenarios.

Effect of mifepristone on uterine fibroids: A systematic review and meta-analysis.

Objective: Uterine fibroids are common benign tumors that cause symptoms like bleeding and pain, with mifepristone showing potential for treatment. This study examines the impact of mifepristone dosage on fibroid size and clinical outcomes to inform future research and treatment.

Methods: A comprehensive search of databases including PubMed, Scopus, and Cochrane Library was conducted up to September 2024.

Catalytic remodeling of complex alkenes to oxonitriles through C=C double bond deconstruction.

Deconstructive transformation of carbon-carbon double bonds (C=C) is a pivotal strategy in synthetic chemistry and drug discovery. Despite the substantial advances in olefin metathesis and ozonolysis for natural product synthesis through C=C double-bond cleavage, the catalytic remodeling of complex molecules through C=C double-bond deconstruction has been underdeveloped. We report a heterogeneous copper-catalyzed C=C double-bond cleavage, which enables the remodeling of complex molecules by converting the carbons on either side of the C=C double bond to carbonyl and cyano groups, respectively.

Dynamic Temporal Alterations of the Cerebellum in Parkinson's Disease With Different Dominant-Affected Sides.

Laterality of motor deficits is a hallmark of Parkinson's disease (PD), which is strongly correlated with disease progression. The cerebellum is an important node in the motor-related network in PD. However, the role of the cerebellum in PD lateralization remains unclear.

Association of dietary intake of saturated fatty acids with obstructive sleep apnea: mediating effects of Life's Crucial 9.

Introduction: Obstructive sleep apnea (OSA) is a global public health issue. Life's Crucial 9 (LC9) is recognized as a powerful tool for assessing cardiovascular health. Although the etiology of OSA remains unclear, saturated fatty acids (SFAs) and cardiovascular health are increasingly regarded as a non-negligible element.

Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment.

Enamel demineralization, the formation of white spot lesions, is a common issue in clinical orthodontic treatment. The appearance of white spot lesions not only affects the texture and health of dental hard tissues but also impacts the health and aesthetics of teeth after orthodontic treatment. The prevention, diagnosis, and treatment of white spot lesions that occur throughout the orthodontic treatment process involve multiple dental specialties.

Circ-0001283 Aggravates Cardiac Hypertrophy by Targeting Myosin Light Chain 3 Protein.

Circular RNAs (circRNAs) are differentially expressed in cardiac hypertrophy; however, the exact function and mechanisms during hypertrophy development are still unknown. Here, we explored the role of a newly discovered circRNA in the pathogenesis of myocardial hypertrophy. It was found that circ-0001283 promoted the progression of cardiac hypertrophy by interacting with myosin light chain 3 (MYL3) to inhibit the protein ubiquitination and enhance its protein expression, not by the competitive endogenous RNA mechanism.

p53-dependent chromatin relaxation is required for DNA double-strand break repair.

The tumor suppressor p53, an indispensable nuclear transcription factor, plays a central role in orchestrating cellular responses when DNA damage occurs. In this study, we demonstrate that in the initial phases of DNA double-strand break (DSB) repair, p53 is rapidly recruited to sites of damage and the surrounding chromatin, where it enhances DSB repair efficiency. This enhancement occurs through the modulation of chromatin dynamics and the promotion of a more relaxed chromatin configuration, a process influenced by p53 in response to DSB-inducing factors such as etoposide, ultraviolet radiation, and nucleases.

Lyophilized apoptotic vesicles improve hemostasis and bone regeneration in traumatic patients with impacted third molar extraction.

Uncontrollable bleeding and tissue defects caused by trauma are significant clinical issues. Apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs) have shown promise for hemostasis and tissue regeneration, but their clinical safety and efficacy remain unverified. We investigated the procoagulant and regenerative function of lyophilized MSC-derived apoVs (MSC-apoVs) using in vitro experiments and in vivo rat models.

A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study.

The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included 1,466 patients from 24 hematology centers, and the validation cohort included 820 patients from an additional 20 centers.

Mitophagy and Its Significance in Periodontal Disease.

Objectives: Periodontal disease is a common chronic inflammatory condition affecting the tissues that support teeth, leading to their destruction. Mitophagy, a specialized form of autophagy responsible for degrading damaged mitochondria, plays a crucial role in maintaining cellular homeostasis. However, its role in periodontal disease progression remains poorly understood.

The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses.

The balance between synaptic excitation and inhibition (E/I) is essential for coordinating motor behavior, yet the differential roles of exocytosis regulators in this balance are less understood. In this study, we investigated the roles of 2 conserved exocytosis regulators, complexin/CPX-1 and CAPS/UNC-31, in excitatory versus inhibitory synapses at Caenorhabditis elegans neuromuscular junctions. cpx-1 null mutants exhibited a marked increase in spontaneous release specifically at excitatory synapses, alongside an unequal reduction in excitatory and inhibitory evoked release.

Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China.

Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China.

Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction.

Objective: To explore the characteristics of cellular senescence in human auricular chondrocytes during long-term in vitro culture and to evaluate the effects of anti-senescence treatments on enhancing their chondrogenic function.

Methods: Auricular chondrocytes exhibited senescence-related characteristics after prolonged expansion in culture. To identify senescence inducers, transcriptome sequencing was performed, with findings corroborated by transmission electron microscopy analyses.

Expert consensus on orthodontic treatment of protrusive facial deformities.

Protrusive facial deformities, characterized by the forward displacement of the teeth and/or jaws beyond the normal range, affect a considerable portion of the population. The manifestations and morphological mechanisms of protrusive facial deformities are complex and diverse, requiring orthodontists to possess a high level of theoretical knowledge and practical experience in the relevant orthodontic field. To further optimize the correction of protrusive facial deformities, this consensus proposes that the morphological mechanisms and diagnosis of protrusive facial deformities should be analyzed and judged from multiple dimensions and factors to accurately formulate treatment plans.

Spatiotemporal changes of vegetation in the northern foothills of Qinling Mountains based on kNDVI considering climate time-lag effects and human activities.

Vegetation is fundamental to regulating the climate system and ensuring carbon balance. Recognizing the effects of climate change (CC) and human activities (HA) is vital for understanding shifts in vegetation. However, climate time-lag effects are rarely measured, resulting in an inadequate assessment of CC's effects on vegetation dynamics.

Characterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus.

Vibrio parahaemolyticus is pathogenic to both humans and marine animals. Antimicrobial-resistant (AMR) bacteria have been reported to cause mortalities in shrimp, with phage therapy presenting an alternative and eco-friendly biocontrol strategy for controlling bacterial diseases. Therefore, this study aimed to isolate and characterize phages for their applicability in lysing Vibrio parahaemolyticus.