Publications by authors named "Lili Chang"

Article Synopsis
  • The text discusses a novel macrophage-based cytopharmaceutical called USIP@M, designed for targeted drug delivery in cancer treatment, utilizing light-triggered mechanisms for localized drug release.
  • This approach involves loading amphiphilic block copolymers with specific drugs and nanoparticles, which are taken up by macrophages to exploit their natural tumor-targeting abilities.
  • The cytopharmaceutical improves the immune response against tumors by polarizing macrophages, enhancing T cell immunity, and effectively killing tumors while ensuring macrophage activity is preserved.
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  • Inappropriate human activities are harming ecosystems in arid regions, highlighting the need for effective vegetation restoration strategies.
  • The paper investigates how optimizing the placement and extent of human activities can help reduce desertification and promote vegetation recovery.
  • Results show that successful restoration relies on balancing the size and number of human activity areas, with findings applicable to various boundary shapes.
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Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult to heal, posing a serious threat to public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of chronic wounds and enhance cellular function holds great significance. Recently, chitosan has emerged as a promising biopolymer for wound healing due to its excellent biocompatibility, biodegradability, and versatile bioactivity.

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Inflammatory Bowel Disease (IBD) is a chronic condition whose incidence has been rising globally. Synbiotic (SYN) is an effective means of preventing IBD. This study investigated the preventive effects and potential biological mechanisms of SYN (Bifidobacterium longum, Lactobacillus acidophilus, and sea buckthorn polysaccharides) on DSS-induced colitis in mice.

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Article Synopsis
  • Networked Turing patterns are formed by groups of nodes with varying density around a stable point, influenced by network features like average degree.
  • The study explores how clustering affects these patterns, using prey-predator models to reveal that increasing clustering can lead to a linear decay in Turing patterns when node densities are evenly distributed.
  • This research connects network topology with the stability of ecological systems, suggesting that understanding clustering can help predict and stabilize pattern formations in real-world networks.
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The traditional clinical approaches for oral cancer consist of surgery, chemotherapy, radiotherapy, immunotherapy, and so on. However, these treatments often induce side effects and exhibit limited efficacy. Photothermal therapy (PTT) emerges as a promising adjuvant treatment, utilizing photothermal agents (PTAs) to convert light energy into heat for tumor ablation.

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Background: Tonoplast intrinsic proteins (TIPs), which typically mediate water transport across vacuolar membranes, play an essential role in plant growth, development, and stress responses. However, their characterization in tigernut (Cyperus esculentus L.), an oil-bearing tuber plant of the Cyperaceae family, is still in the infancy.

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  • Immune checkpoint inhibitors (ICIs) combined with antiangiogenic therapy have potential benefits for treating advanced liver cancer (HCC) but face challenges due to tumors that evade immune detection.
  • A new strategy using a black phosphorus-based self-delivery system called BPSP aims to enhance the effectiveness of ICIs by promoting photothermal therapy, which helps improve drug delivery and immune cell infiltration.
  • The BPSP approach not only releases therapeutic agents but also reconfigures the tumor environment, effectively converting 'cold' tumors into 'hot' ones, leading to better immune responses and treatment outcomes in mice.
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Inflammatory bowel disease (IBD) is a chronic and recurrent disease. Increasing evidence suggests a higher incidence of depression in IBD patients compared with the general population, but the underlying mechanism remains uncertain. Rattan pepper polysaccharide (RPP) is an important active ingredient of rattan pepper, yet its effects and mechanisms on intestinal inflammation and depression-like behavior remain largely unknown.

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Turing patterns arising from reaction-diffusion systems such as epidemic, ecology or chemical reaction models are an important dynamic property. Parameter identification of Turing patterns in spatial continuous and networked reaction-diffusion systems is an interesting and challenging inverse problem. The existing algorithms require huge account operations and resources.

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Plaque biofilms play critical roles in the development of dental caries. Mechanical plaque control methods are considered to be most effective for plaque removal, such as brushing teeth or using flosser. Recently, water flosser has been paid much attention.

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CeOLE genes exhibit a tuber-predominant expression pattern and their mRNA/protein abundances are positively correlated with oil accumulation during tuber development. Overexpression could significantly increase the oil content of tobacco leaves. Oleosins (OLEs) are abundant structural proteins of lipid droplets (LDs) that function in LD formation and stabilization in seeds of oil crops.

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During orthodontic treatment, the patients are susceptible to dental caries as a result of the bacterial adhesion and biofilm formation around the orthodontic brackets. Prevention of the caries-related biofilm formation is of significance for maintaining both aesthetics and health of the teeth. Herein, the brackets were functionalized with antibacterial activity via coating a layer of non-crosslinked chitosan (CS).

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Cancer immunotherapy has become a promising strategy. However, the effectiveness of immunotherapy is restricted in "cold tumors" characterized with insufficient T cells intratumoral infiltration and failed T cells priming. Herein, an on-demand integrated nano-engager (JOT-Lip) was developed to convert cold tumors to hot "increased DNA damage and dual immune checkpoint inhibition" strategy.

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Targeting tumour immunosuppressive microenvironment is a crucial strategy in immunotherapy. However, the critical role of the tumour lymph node (LN) immune microenvironment (TLIME) in the tumour immune homoeostasis is often ignored. Here, we present a nanoinducer, NIL-IM-Lip, that remodels the suppressed TLIME via simultaneously mobilizing T and NK cells.

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Cytotoxic T lymphocytes (CTLs) are central effector cells in antitumor immunotherapy. However, the complexity of immunosuppressive factors in the immune system contributes to the low response rates of current CTL-based immunotherapies. Here, we propose a novel holistic strategy including a priming response, promoting activity, and relieving suppression of CTLs, aiming to strengthen the effect of personalized postoperative autologous nanovaccines.

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Currently, definitive treatment for neurodegenerative diseases without side effects has not been developed, therefore, exploring natural polysaccharides with neuroprotection to prevent the occurrences and progressions of cognitive dysfunctions has important significance. The purpose of this study was to investigate the effects of sea buckthorn polysaccharide (SBP) on high-fat diet (HFD) induced mice cognitive dysfunctions and attempted to explore its biological mechanisms. Behavior tests (Y-maze and Barnes maze) suggested that SBP effectively alleviated the HFD induced behavioral disorders, which was in accordance with the inhibition of neuroinflammation via suppressing the NF-κB pathway and amelioration of synaptic dysfunction via upregulating CREB/BDNF/TrkB pathway in mice brain.

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The spontaneous emergence of patterns in nature, such as stripes and spots, can be mathematically explained by reaction-diffusion systems. These patterns are often referred as Turing patterns to honor the seminal work of Alan Turing in the early 1950s. With the coming of age of network science, and with its related departure from diffusive nearest-neighbor interactions to long-range links between nodes, additional layers of complexity behind pattern formation have been discovered, including irregular spatiotemporal patterns.

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Separation of nucleic acids and proteins using gels has always been a crucial part of molecular biology research. For low-molecular-weight nucleic acids and proteins, low- and medium-concentration agarose gels cannot achieve the high resolution as polyacrylamide gels. We found that 6 %-14 % high-concentration agarose gels (HAGs) could be easily dissolved in an autoclave and the vertical gel cast can be effortlessly filled using an easy-made plastic box.

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Background: Cistanche tubulosa is an editable and medicinal traditional Chinese herb and phenylethanoid glycosides are its major components, which have shown various beneficial effects such as anti-tumor, anti-oxidant and neuroprotective activities. However, the anti-obesity effect of C. tubulosa phenylethanoid glycosides (CTPG) and their regulatory effect on gut microbiota are still unclear.

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The Turing pattern is an important dynamic behavior characteristic of activator-inhibitor systems. Differentiating from traditional assumption of activator-inhibitor interactions in a spatially continuous domain, a Turing pattern in networked reaction-diffusion systems has received much attention during the past few decades. In spite of its great progress, it still fails to evaluate the precise influences of network topology on pattern formation.

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Insulin resistance (IR) is a pathological reaction of hyperinsulinemia and impaired glucose tolerance caused by decreased sensitivity of target tissues such as liver to insulin.The pathogenesis of IR as a typical pathological feature of type 2 diabetes is the focus of anti-diabetes research.In this paper,we reviewed the molecular mechanisms of glucose and lipid metabolism,oxidative stress,mitochondrial dysfunction,endoplasmic reticulum stress,inflammation,and hepatic IR in the case of type 2 diabetes mellitus,which might provide new ideas and theoretical guidance for the treatment of diabetes mellitus.

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Photothermal therapy (PTT) is a promising strategy for cancer treatment, but its clinical application relies heavily on accurate tumor positioning and effective combination. Nanotheranostics has shown superior application in precise tumor positioning and treatment, bringing potential opportunities for developing novel PTT-based therapies. Here, a nanotheranostic agent is proposed to enhance magnetic resonance imaging (MRI)/ near-infrared fluorescence imaging (NIRFI) imaging-guided photo-induced triple-therapy for cancer.

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Reaction-diffusion processes organized in networks have attracted much interest in recent years due to their applications across a wide range of disciplines. As one type of most studied solutions of reaction-diffusion systems, patterns broadly exist and are observed from nature to human society. So far, the theory of pattern formation has made significant advances, among which a novel class of instability, presented as wave patterns, has been found in directed networks.

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Patterns in nature are fascinating both aesthetically and scientifically. Alan Turing's celebrated reaction-diffusion model of pattern formation from the 1950s has been extended to an astounding diversity of applications: from cancer medicine, via nanoparticle fabrication, to computer architecture. Recently, several authors have studied pattern formation in underlying networks, but thus far, controlling a reaction-diffusion system in a network to obtain a particular pattern has remained elusive.

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