Balance guided incomplete multi-view spectral clustering.

There is a large volume of incomplete multi-view data in the real-world. How to partition these incomplete multi-view data is an urgent realistic problem since almost all of the conventional multi-view clustering methods are inapplicable to cases with missing views. In this paper, a novel graph learning-based incomplete multi-view clustering (IMVC) method is proposed to address this issue.

Identification of Potential Inhibitors of PDE5 based on Structure-based Virtual Screening Approaches.

Background: Phosphodiesterase type 5 (PDE5), exclusively specific for cyclic guanidine monophosphate (cGMP), a potential target for the therapy of various diseases, and PDE5 inhibitors could be used as a treatment for erectile dysfunction (ED) or chronic pulmonary hypertension.

Objective: In the present study, we carried out an integrated computer-aided virtual screening technique against the natural products in the ZINC database to discover potential inhibitors of PDE5.

Methods: Pharmacophore, molecular docking and ADMET (Absorption, distribution, metabolism, excretion and toxicity) properties filtration were used to select the PDE5 inhibitors with the best binding affinities and drug-like properties.

Breast Mass Detection in Mammography Based on Image Template Matching and CNN.

In recent years, computer vision technology has been widely used in the field of medical image processing. However, there is still a big gap between the existing breast mass detection methods and the real-world application due to the limited detection accuracy. It is known that humans locate the regions of interest quickly and further identify whether these regions are the targets we found.

Advances in L-Type Calcium Channel Structures, Functions and Molecular Modeling.

L-type Calcium Channels (LTCCs), also termed as Ca1, belong to voltage-gated calcium channels (VGCCs/Cas), which play a critical role in a wide spectrum of physiological processes, including neurotransmission, cell cycle, muscular contraction, cardiac action potential and gene expression. Aberrant regulation of calcium channels is involved in neurological, cardiovascular, muscular and psychiatric disorders. Accordingly, LTCCs have been regarded as important drug targets, and a number of LTCC drugs are in clinical use.