Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion.

We previously showed that fetal exposure to maternal type 1 diabetes (T1D) is associated with altered glucose-stimulated insulin secretion in adult offspring. Here, we investigated whether this -cell defect displays a sex dimorphism. Twenty-nine adult nondiabetic offspring of T1D mothers (ODMs) were compared with 29 nondiabetic offspring of T1D fathers.

Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.

Background: Fetal exposure to hyperglycemia impacts negatively kidney development and function.

Objective: Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in peripheral blood cells and whether those alterations are related to impaired kidney function in adult offspring.

Design: Twenty nine adult, non-diabetic offspring of mothers with type 1 diabetes (T1D) (case group) were matched with 28 offspring of T1D fathers (control group) for the study of their leukocyte genome-wide DNA methylation profile (27,578 CpG sites, Human Methylation 27 BeadChip, Illumina Infinium).

β- and α-cell dysfunctions in africans with ketosis-prone atypical diabetes during near-normoglycemic remission.

Objective: Ketosis-prone atypical diabetes (KPD) is a subtype of diabetes in which the pathophysiology is yet to be unraveled. The aim of this study was to characterize β- and α-cell functions in Africans with KPD during remission.

Research Design And Methods: We characterized β- and α-cell functions in Africans with KPD during remission.

Multitissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetes.

Objective: To characterize insulin action in Africans with ketosis-prone diabetes (KPD) during remission.

Research Design And Methods: At Saint-Louis Hospital, Paris, France, 15 African patients with KPD with an average 10.5-month insulin-free near-normoglycemic remission period (mean A1C 6.

Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-saharan africans.

Context: An atypical form of type 2 diabetes mellitus (DM-2) is revealed by ketosis (ketosis-prone type 2 diabetes mellitus), frequently occurring in individuals who are black and of African origin, and characterized by an acute onset requiring transient insulin therapy. Its sudden onset suggests precipitating factors.

Objective: To investigate the putative role of human herpesvirus 8 (HHV-8) in the pathogenesis of ketosis-prone DM-2.

Consequences of fetal exposure to maternal diabetes in offspring.

Context: Type 2 diabetes is the result of both genetic and environmental factors. Fetal exposure to maternal diabetes is associated with a higher risk of abnormal glucose homeostasis in offspring beyond that attributable to genetic factors, and therefore, may participate in the excess of maternal transmission of type 2 diabetes.

Evidence Acquisition: A MEDLINE search covered the period from 1960-2005.