Publications by authors named "Lila Close"
Article Synopsis
- Viruses are a major part of the human gut microbiome, influencing health and disease, but the effects of HIV on this viral community are not well understood.
- This study analyzed the gut virome composition of non-HIV-infected volunteers, naive HIV-infected patients, and those treated with integrase strand transfer inhibitors (INSTIs) using shotgun sequencing.
- Results showed that HIV infection reduces phage diversity, but INSTIs treatment partially restores viral balance; however, it does not fully address the changes associated with HIV, indicating potential for future microbiota-focused therapies.
Gut viruses are important, yet often neglected, players in the complex human gut microbial ecosystem. Recently, the number of human gut virome studies has been increasing; however, we are still only scratching the surface of the immense viral diversity. In this study, 254 virus-enriched fecal metagenomes from 204 Danish subjects were used to generate the anish nteric irme atalog (DEVoC) containing 12,986 nonredundant viral scaffolds, of which the majority was previously undescribed, encoding 190,029 viral genes.
View Article and Find Full Text PDFEmergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice.
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