Publications by authors named "Lil-Sofie Ording-Muller"

Precocious puberty in girls is defined by the appearance of secondary sex characteristics before the age of 8 years. Precocious puberty is either peripheral or central. In most cases, the cause of central precocious puberty is unknown.

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Voiding cystourethrography (VCUG) is a fluoroscopic technique that allows the assessment of the urinary tract, including the urethra, bladder, and-if vesicoureteral reflux (VUR) is present-the ureters and the pelvicalyceal systems. The technique also allows for the assessment of bladder filling and emptying, providing information on anatomical and functional aspects. VCUG is, together with contrast-enhanced voiding urosonography (VUS), still the gold standard test to diagnose VUR and it is one of the most performed fluoroscopic examinations in pediatric radiology departments.

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Background: Liver transplantation is the state-of-the-art curative treatment for end-stage liver disease. Imaging is a key element in the detection of postoperative complications. So far, limited data is available regarding the best radiologic approach to monitor children after liver transplantation.

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Article Synopsis
  • Liver transplantation is the primary treatment for end-stage liver disease, but there's limited information on the best imaging practices for monitoring children during the procedure.
  • A survey conducted by the European Society of Pediatric Radiology gathered feedback from 22 centers across 11 countries regarding their intraoperative imaging techniques.
  • Results showed that all centers use intraoperative ultrasound (US), mainly relying on color Doppler, but there's significant variation in how the ultrasound is conducted, including who operates the equipment and how often imaging is performed.
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Background: Image-guided intussusception reduction has been practised internationally for many decades. The use of different modalities, delayed repeat attempts, and sedation/anaesthesia are unknown.

Objective: To survey the practice of image-guided intussusception reduction.

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Background: Liver transplantation is the state-of-the-art curative treatment in end-stage liver disease. Imaging is a key element for successful organ-transplantation to assist surgical planning. So far, only limited data regarding the best radiological approach to prepare children for liver transplantation is available.

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Objective: To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma.

Material And Methods: We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was performed according to institutional protocols.

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  • - The study aimed to compare two MRI sequences—T2 Dixon fat-only and T1-weighted—in assessing high signal areas in bone marrow of healthy children and adolescents, focusing on optimizing scan time.
  • - Data from 196 participants aged 6 to 19 years were analyzed, and a scoring system classified findings as "minor" or "major," with high agreement (94.6%) between sequences for the majority of assessed areas.
  • - The findings suggest that T2 Dixon fat-only can effectively replace T1-weighted sequences for kids over nine, leading to reduced MRI scan durations.
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Introduction: Radiographs of the hand and teeth are frequently used for medical age assessment, as skeletal and dental maturation correlates with chronological age. These methods have been criticized for their lack of precision, and magnetic resonance imaging (MRI) of the knee has been proposed as a more accurate method. The aim of this systematic review is to explore the scientific and statistical evidence for medical age estimation based on skeletal maturation as assessed by MRI of the knee.

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  • The study investigates high signal areas on T2 weighted MRI images of the bone marrow in the axial skeleton of healthy children and adolescents aged 5-19 years.
  • A total of 196 participants were examined, leading to the identification of 415 areas of increased signal, with 75 categorized as major findings, particularly in the pelvis.
  • The findings highlighted the prevalence of non-specific bone marrow hyperintensities, emphasizing the need for awareness to differentiate these from actual skeletal diseases in children.
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Anorectal and cloacal malformations are a broad mix of congenital abnormalities related to the distal rectum and anus. Confusion exists between all the forms in this large and heterogeneous group. The spectrum includes everything from anal stenosis, ventral anus, anal atresia (with and without fistula) and the full spectrum of cloacal malformations.

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Article Synopsis
  • The study aimed to analyze bone marrow appearances in the appendicular skeleton of healthy children and adolescents using whole-body MRI with fat suppression.
  • It involved 196 participants aged 5-19 years, where bone marrow signals were graded for intensity and extension using a newly created scoring system.
  • Results showed that over half of the individuals displayed significant focal areas of high signal intensity, primarily in the hands, humerus, feet, and knees, highlighting the need for careful interpretation of MRI findings in this population.
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  • Whole-body MRI is gaining popularity in children, but there hasn't been a study on its reliability until now.
  • This study aimed to evaluate how consistently radiologists can score high signal areas in bone marrow using a specific scoring system on MRI images.
  • The findings showed that assessing signal intensity and extension of these areas had good reliability between different observers, while the evaluation of shape and contour was less consistent.
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  • Manual evaluation of bone marrow signals is time-consuming and requires strict standardization for accuracy.
  • The study aimed to explore the use of deep learning to automate the segmentation of bone marrow signals in young individuals using knee MRI images from a multi-centered study.
  • Results indicated that the deep-learning model performed well for lower intensity signals but struggled with higher intensity signals, suggesting the need for more extensive training datasets and cross-institutional validation to enhance accuracy.
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Fontan surgery is a life-saving procedure for newborns with complex cardiac malformations, but it originates complications in different organs. The liver is also affected, with development of fibrosis and sometimes cirrhosis and hepatocellular carcinoma. There is no general agreement on how to follow-up these children for the development of liver disease.

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Since Francis Fontan first introduced the eponymous technique, the Fontan procedure, this type of surgical palliation has allowed thousands of children affected by specific heart malformations to reach adulthood. Nevertheless, abdominal, thoracic, lymphatic and neurologic complications are the price that is paid by these patients. Our review focuses on Fontan-associated liver disease; the purpose is to summarize the current understanding of its physiopathology, the aim of follow-up and the specific radiologic follow-up performed in Europe.

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We aim to present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses to biliary cirrhosis, end-stage liver failure and death within the first years of life. Differentiating biliary atresia from other nonsurgical causes of neonatal cholestasis is difficult as there is no single method for diagnosing biliary atresia and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis.

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Purpose: Patients with Fontan circulation are at risk of developing hepatic fibrosis/cirrhosis. The mechanisms and disease development are unclear and early secondary liver cancer is a concern. This study will describe hepatic imaging findings in a national cohort of adolescents with Fontan circulation.

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We present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses towards biliary cirrhosis, end-stage liver failure and death by age 3. Differentiation of biliary atresia from other nonsurgical causes of neonatal cholestasis is challenging because there is no single method for diagnosing biliary atresia, and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis.

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Background: Imaging for osteoporosis has two major aims, first, to identify the presence of low bone mass (osteopenia), and second, to quantify bone mass using semiquantitative (conventional radiography) or quantitative (densitometry) methods. In young children, densitometry is hampered by the lack of reference values, and high-quality radiographs still play a role although the evaluation of osteopenia as a marker for osteoporosis is subjective and based on personal experience. Medical experts questioned in court over child abuse, often refer to the literature and state that 20-40% loss of bone mass is warranted before osteopenia becomes evident on radiographs.

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  • Chronic nonbacterial osteomyelitis (CNO) is a rare bone disorder characterized by inflammatory lesions, diagnosed in children based on specific criteria that exclude infections and malignancies.
  • A study analyzed MRI findings in 75 children diagnosed with CNO from 2012 to 2018, revealing that pain was a common symptom, along with raised inflammatory markers in a majority of cases.
  • The results showed that boys and girls are affected similarly, with the most commonly involved bones being the femur, tibia, and pelvis; isolated back pain was notably reported in about 24% of the cases, especially among girls.
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