[Molecular Pathogenic Mechanism Study of Two Cases of Inherited Dysfibrinogenemia].

Objective: To analyze two families with inherited dysfibrinogenemia, and explore the molecular pathogenic mechanisms.

Methods: The coagulation indexes of the probands and their family members were detected. The , and exons and their flanking sequences were amplified by PCR, and the mutation sites were identified by sequencing.

Dual-mode visual fluorescent/colorimetric ratio sensing of alkaline phosphatase in milk based on porphyrinic MOF photonanozyme fibers.

The detection of alkaline phosphatase (ALP) in milk is crucial for determining the safety of dairy products, but single mode detection may result in false positives or false negatives. This work presents a dual-mode visual fluorescent/colorimetric ratio sensor for highly sensitive detection of ALP. Zinc meso-tetra(4-carboxyphenyl) porphyrin (ZnTCPP) metal-organic frameworks (MOFs) were grown on polyacrylonitrile with AlO layers (Al-ZnTCPP@PAN).

A Graphene/MXene-Modified Flexible Fabric for Infrared Camouflage, Electrothermal, and Electromagnetic Interference Shielding.

Although materials with infrared camouflage capabilities are increasingly being produced, few applications exist in clothing fabrics. Here, graphene/MXene-modified fabric with superior infrared camouflage, Joule heating, and electromagnetic shielding capabilities all in one was prepared by simply scraping a graphene slurry onto alkali-treated cotton fabrics, followed by spraying MXene. The functionality of the modified fabrics after different treatment times was then tested and analyzed.

Advancing surgical education: An evaluation of laparoscopic simulation training for medical students.

Objective: To examine the medical students' awareness of laparoscopic surgery as well as assess the perceived importance of laparoscopic simulation training, and its impact on students' confidence, career aspirations, proficiency, spatial skills, and physical tolerance.

Design: Descriptive and comparative study using pre- and post-training assessments.

Setting: Simulation training sessions centred on laparoscopic surgery techniques.

Predictors of breakthrough invasive fungal infections (BIFI) in pediatric acute leukemia: a retrospective analysis and predictive model development.

Objective: This study aims to identify key risk factors associated with the development of breakthrough invasive fungal infections (BIFI) in pediatric acute leukemia patients to improve early detection and intervention strategies.

Method: A retrospective analysis was conducted on 160 pediatric patients with acute leukemia admitted to Anhui Provincial Children's Hospital between October 2018 and June 2022. The study evaluated the impact of various clinical parameters on BIFI risk using univariate and multivariable analyses, with data including patient demographics, treatment regimens, and infection outcomes.

secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.

Background: -secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides (DSIP-CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects. This study investigates these properties using a p-chlorophenylalanine (PCPA) -induced insomnia model in mice, an approach akin to traditional methods evaluating sleep-promoting activities in fusion peptides.

Aim Of The Study: The research aims to elucidate the sleep-promoting mechanism of DSIP-CBBBP, exploring its impact on neurotransmitter levels and sleep regulation, and to analyze its composition and structure.

Smart Green Cotton Textiles with Hierarchically Responsive Conductive Network for Personal Healthcare and Thermal Management.

Whereas cotton as an abundant natural cellulose has been widely used for sustainable and skin-friendly textiles and clothes, developing cotton fabrics with smart functions that could respond to various stimuli is still eagerly desired while remaining a great challenge. Herein, smart multiresponsive cotton fabric with hierarchically copper nanowire interwoven MXene conductive networks that are seamlessly assembled along a 3D woven fabric template for efficient personal healthcare and thermal comfort regulation is successfully developed. The robust hierarchically interwoven conductive network was "glued" and protected by organic conductive polymer poly(3,4-ethylenedioxythiophene) along a 3D interconnected fabric template to enhance interfacial adherent and environmental stability.

Impact of exercise on cancer: mechanistic perspectives and new insights.

This review critically evaluates the substantial role of exercise in enhancing cancer prevention, treatment, and patient quality of life. It conclusively demonstrates that regular physical activity not only reduces cancer risk but also significantly mitigates side effects of cancer therapies. The key findings include notable improvements in fatigue management, reduction of cachexia symptoms, and enhancement of cognitive functions.

Functionalized Face Masks as Smart Wearable Sensors for Multiple Sensing.

Wearable sensors provide continuous physiological information and measure deviations from healthy baselines, resulting in the potential to personalize health management and diagnosis of diseases. With the emergence of the COVID-19 pandemic, functionalized face masks as smart wearable sensors for multimodal and/or multiplexed measurement of physical parameters and biochemical markers have become the general population for physiological health management and environmental pollution monitoring. This Review examines recent advances in applications of smart face masks based on implantation of digital technologies and electronics and focuses on respiratory monitoring applications with the advantages of autonomous flow driving, enrichment enhancement, real-time monitoring, diversified sensing, and easily accessible.

[Clinical phenotypes and genotypes of congenital fibrinogen disorder: an analysis of 16 children].

Objectives: To investigate the clinical phenotypes and genotypes of children with congenital fibrinogen disorder (CFD).

Methods: A retrospective analysis was conducted on the clinical data of 16 children with CFD. Polymerase chain reaction was used to amplify all exons and flanking sequences of the , , and genes, and sequencing was performed to analyze mutation characteristics.

Underwater Gesture Recognition Meta-Gloves for Marine Immersive Communication.

Rapid advancements in immersive communications and artificial intelligence have created a pressing demand for high-performance tactile sensing gloves capable of delivering high sensitivity and a wide sensing range. Unfortunately, existing tactile sensing gloves fall short in terms of user comfort and are ill-suited for underwater applications. To address these limitations, we propose a flexible hand gesture recognition glove (GRG) that contains high-performance micropillar tactile sensors (MPTSs) inspired by the flexible tube foot of a starfish.

Zinc porphyrin/MXene hybrids with phosphate-induced stimuli-responsive behavior for dual-mode fluorescent/electrochemiluminescent ratiometric biosensing.

Highly sensitive ratiometric biosensors have attracted much attention in biomarker detection, but most rely on single-mode signals, which can affect accuracy. The development of new principles and methods for dual-mode ratiometric sensing can enhance detection accuracy. Herein, the zinc(II) meso-tetra(4-carboxyphenyl) porphyrin/MXene (ZnTCPP/TiCT) hybrids with phosphate-induced stimuli-responsive behavior are used to develop a novel dual-mode fluorescent/electrochemiluminescent (FL/ECL) ratiometric biosensor.

Two-Dimensional Nickel Porphyrinic Metal-Organic Framework-Modified Electrode for Electrochemical Sensing.

Due to their highly exposed active sites and high aspect ratio caused by their substantial lateral dimension and thin thickness, two-dimensional (2D) metal-organic framework (MOF) nanosheets are currently considered a potential hybrid material for electrochemical sensing. Herein, we present a nickel-based porphyrinic MOF nanosheet as a versatile and robust platform with an enhanced electrochemical detection performance. It is important to note that the nickel porphyrin ligand reacted with Cu(NO)·3HO in a solvothermal process, with polyvinylpyrrolidone (PVP) acting as the surfactant to control the anisotropic development of creating a 2D Cu-TCPP(Ni) MOF nanosheet structure.

Core-Sheath Heterogeneous Interlocked Conductive Fiber Enables Smart Textile for Personalized Healthcare and Thermal Management.

Whereas thermal comfort and healthcare management during long-term wear are essentially required for wearable system, simultaneously achieving them remains challenge. Herein, a highly comfortable and breathable smart textile for personal healthcare and thermal management is developed, via assembling stimuli-responsive core-sheath dual network that silver nanowires(AgNWs) core interlocked graphene sheath induced by MXene. Small MXene nanosheets with abundant groups is proposed as a novel "dispersant" to graphene according to "like dissolves like" theory, while simultaneously acting as "cross-linker" between AgNWs and graphene networks by filling the voids between them.

LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation.

To uncover the biological role of lncRNA DCST1-AS1 in the process of pediatric AML and its regulatory effect on p53 methylation. Serum level of DCST1-AS1 in AML children and healthy participants was detected by qRT-PCR. The role of DCST1-AS1 in mediating biological functions of AML193 and U937 cells was assessed by functional experiments.

3D laparoscopic treatment of bladder cancer with pelvic multi-organ invasion: a case report and literature review.

Introduction: Radical cystectomy with dissection of pelvic lymph nodes and urethral diversion is the standard surgical treatment for muscle-invasive non-metastatic bladder cancer. In rare cases where patients with bladder cancer without distant metastasis have pelvic multi-organ invasion, the cancer compresses or invades the ureter and, in severe cases, leads to bilateral upper urinary tract obstruction and renal damage. The treatment recommended by guidelines often cannot improve the patients' clinical symptoms immediately, and patients cannot complete the treatment owing to severe side effects, resulting in poor survival benefits.

Template-Free and Stretchable Conductive Fiber with a Built-In Helical Structure for Strain-Insensitive Signal Transmission.

With the rapid development of intelligent electronic devices, conductive fibers have become very critical to signal transmission devices. However, metal-based rigid conductive wires, such as high-modulus copper and silver wires, are prone to signal failure owing to tensile breakage under large strain conditions. Therefore, strain-insensitive stretchable conductive fibers for signal transmission are critical for next-generation wearable devices.

Autonomous Electroluminescent Textile for Visual Interaction and Environmental Warning.

Visual interaction is a promising strategy for the externalized expression and transmission of information, having wide application prospects in wearable luminous textiles. Achieving an autonomous luminous display and dynamic light response to environmental stimuli is attractive but attracts little attention. Herein, we propose a liquid responsive structure based on alternating-current electroluminescent fibers and demonstrate conductive-liquid-bridging electroluminescent fabrics with high integration and personalized patterns.

The initial experience of 4.5/6.5 Fr ureteroscopic laser lithotripsy under topical intraurethral anesthesia supplemented by preoperative and intraoperative medications.

Purpose: To assess the safety and effectiveness of the 4.5/6.5 Fr ureteroscopic laser lithotripsy (URSL) under topical intraurethral anesthesia (TIUA) compared to spinal anesthesia (SA).

Skin-Friendly and Wearable Iontronic Touch Panel for Virtual-Real Handwriting Interaction.

Touch panels are deemed as a critical platform for the future of human-computer interaction and metaverse. Recently, stretchable iontronic touch panels have attracted attention due to their superior adhesivity to the human body. However, such adhesion can not be named "real wearable", leading to discomfort for the wearer, such as rashes or itching with long-time wearing.

Analysis of gene mutations in adverse events during first induction chemotherapy in childhood acute lymphoblastic leukemia.

Background: The rat sarcoma virus () pathway controls cell proliferation, differentiation, and apoptosis, which have been implicated in the pathogenesis of various hematological malignancies. Prognostic importance of gene mutation, relatively frequently in childhood acute lymphoblastic leukemia (ALL), has been debated. We aimed to study gene mutation profile and prognosis in 93 children with newly diagnosed ALL.

Corrigendum: Recent advances in metal-organic framework- based electrochemical biosensing applications.

[This corrects the article DOI: 10.3389/fbioe.2021.