Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury.

Purpose: Compound probiotics have been reported to ameliorate imbalances in the intestinal flora that may play a critical role in neuropathic pain. This study aimed to investigate the efficacy of compound probiotic treatment on neuropathic pain.

Methods: Thirty mice were randomly divided into three groups: 1) sham group, 2) mouse with chronic constrictive injury (CCI), and 3) probiotic gavage with CCI (CCI+Prob).

Popcorn-stick-like NH-UiO-66/TiO nanotube nanocomposites toward optimized photocatalytic carbon oxidation with nitrogen dioxide.

Developing photocatalytic technologies for pollutants removal with high harmless product selectivity is a significant challenge. Construction and optimization of nanocomposites junction with appropriate band alignments is an effective method for achieving this objective. Herein, a unique popcorn-stick-like NH-UiO-66/TiO nanotube nanocomposites with staggered band alignment is fabricated.

Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells.

Wholly defined expansion conditions for biliary tree stem cell (BTSC) organoids were established, consisting of a defined proliferative medium (DPM) used in combination with soft hyaluronan hydrogels. The DPM consisted of commercially available Kubota's Medium (KM), to which a set of small molecules, particular paracrine signals, and heparan sulfate (HS) were added. The small molecules used were DNA methyltransferase inhibitor (RG108), TGF- β Type I receptor inhibitor (A83-01), adenylate cyclase activator (Forskolin), and L-type Ca channel agonist (Bay K8644).

Protective properties of Ophiopogonin D in DSS-induced colitis: insights into microbiota modulation.

Background: Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is becoming increasingly prevalent worldwide. Ophiopogonin D, which is derived from Ophiopogon japonicus, exhibits anti-inflammatory and antioxidant properties, yet its therapeutic potential in UC remains unclear.

Methods: In this study, we employed a mouse model of DSS-induced colitis to assess the impact of Ophiopogonin D on various parameters, including weight loss, bloody stools, and inflammation in the colon.

How the root bacterial community of responds to nematode infection: enrichments of nitrogen-fixing and nematode-antagonistic bacteria in the parasitized organs.

Plant-parasitic nematodes (PPNs) are among the most damaging pathogens to host plants. Plants can modulate their associated bacteria to cope with nematode infections. The tritrophic plant-nematode-microbe interactions are highly taxa-dependent, resulting in the effectiveness of nematode agents being variable among different host plants.

Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An Open-Label, Randomized, Nonplacebo-Controlled Study.

Fibromyalgia (FM) is a complex and poorly understood disorder characterized by chronic and widespread musculoskeletal pain, of which the etiology remains unknown. Now, the disorder of the gut microbiome is considered as one of the main causes of FM. This study aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM.

Surface and interface engineering of BiOCl nanomaterials and their photocatalytic applications.

BiOCl materials have received much attention because of their unique optical and electrical properties. Still, their unsatisfactory catalytic performance has been troubling researchers, limiting the application of BiOCl-based photocatalysts. Therefore, many researchers have studied the adjustment of BiOCl-based materials to enhance photocatalytic efficiency.

Bi/Mn-Doped BiOCl Nanosheets Self-Assembled Microspheres toward Optimized Photocatalytic Performance.

Doping engineering of metallic elements is of significant importance in photocatalysis, especially in the transition element range where metals possess empty 'd' orbitals that readily absorb electrons and increase carrier concentration. The doping of Mn ions produces dipole interactions that change the local structure of BiOCl, thus increasing the specific surface area of BiOCl and the number of mesoporous distributions, and providing a broader platform and richer surface active sites for catalytic reactions. The combination of Mn doping and metal Bi reduces the forbidden bandwidth of BiOCl, thereby increasing the absorption in the light region and strengthening the photocatalytic ability of BiOCl.

High-Crystallinity BiOCl Nanosheets as Efficient Photocatalysts for Norfloxacin Antibiotic Degradation.

Semiconductor photocatalysts are essential materials in the field of environmental remediation. Various photocatalysts have been developed to solve the contamination problem of norfloxacin in water pollution. Among them, a crucial ternary photocatalyst, BiOCl, has attracted extensive attention due to its unique layered structure.

Construction of 2D/2D Mesoporous WO/CeO Laminated Heterojunctions for Optimized Photocatalytic Performance.

Photocatalytic elimination of antibiotics from the environment and drinking water is of great significance for human health. However, the efficiency of photoremoval of antibiotics such as tetracycline is severely limited by the prompt recombination of electron holes and slow charge migration efficacy. Fabrication of low-dimensional heterojunction composites is an efficient method for shortening charge carrier migration distance and enhancing charge transfer efficiency.

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis.

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (IBD), which has been suggested to promote disease development and progression. However, the molecular mechanisms by which intestinal inflammation may aggravate cholestatic liver disease remain incompletely understood.

An in vivo evaluation of clear aligners for optimal orthodontic force and movement to determine high-efficacy and periodontal-friendly aligner staging.

Objectives: To investigate the effect of aligner displacement on tooth movement and periodontal health to improve the efficiency of aligner treatment and explore the mechanism in vivo.

Methods: A two-tooth site was established by a finite element (FE) model to virtually evaluate aligner staging. A randomized controlled experiment was conducted when the tooth sites in beagles were treated with fixed or aligner appliances with different movement and force, and tooth movement and internal structure were recorded during the alignment.

Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a major health burden associated with the metabolic syndrome leading to liver fibrosis, cirrhosis and ultimately liver cancer. In humans, the PNPLA3 I148M polymorphism of the phospholipase patatin-like phospholipid domain containing protein 3 (PNPLA3) has a well-documented impact on metabolic liver disease. In this study, we used a mouse model mimicking the human PNPLA3 I148M polymorphism in a long-term high fat diet (HFD) experiment to better define its role for NAFLD progression.

The Effects of Extract on Autophagy in Human Macrophages Stimulated by Cigarette Smoke Extract.

Objective: To investigate the effects of extract (GBE) on autophagy in human macrophages stimulated by cigarette smoke extract (CSE).

Methods: The human monocyte cell line U937 was cultured , and phorbol ester (PMA) was added to the cell culture medium to induce differentiation into human macrophages. CSE was prepared by traditional methods for experiments.

Recent Advances in Black TiO Nanomaterials for Solar Energy Conversion.

Titanium dioxide (TiO) nanomaterials have been widely used in photocatalytic energy conversion and environmental remediation due to their advantages of low cost, chemical stability, and relatively high photo-activity. However, applications of TiO have been restricted in the ultraviolet range because of the wide band gap. Broadening the light absorption of TiO nanomaterials is an efficient way to improve the photocatalytic activity.

[Research progress on the relationship between gut-liver axis disorder and sepsis].

Sepsis is a life-threatening organ dysfunction caused by an uncontrolled host response to infection. The mechanism of sepsis is extremely complicated and the mortality is still high. Persistent researches provide an important way to break through the "bottleneck" of clinical diagnosis and treatment of sepsis.

Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial.

Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.

Surface engineering of hematite nanorods photoanode towards optimized photoelectrochemical water splitting.

Rapid charge recombination in hematite (FeO) during photoelectrochemical water splitting is a major obstacle to achieving high-efficiency photoelectrodes. Surface defect engineering is considered as a viable strategy for enhancing photoelectrochemical activity of oxide photoanodes. Herein, a one-dimensional (1D) defective γ-FeO nanorods (DFNRs) photoanode is prepared using solvothermal and high-temperature hydrogenation strategies.

16-membered ring macrolides and erythromycin induce ermB expression by different mechanisms.

Background: Ribosome stalling on ermBL at the tenth codon (Asp) and mRNA stabilization are believed to be mechanisms by which erythromycin (Ery) induces ermB expression. Expression of ermB is also induced by 16-membered ring macrolides (tylosin, josamycin and spiramycin), but the mechanism underlying this induction is unknown.

Methods: We introduced premature termination codons, alanine-scanning mutagenesis and amino acid mutations in ermBL and ermBL2.

Clinical Effects and Safety of the Use of Methylene Blue for the Treatment of Lumbar Facet Joint Syndrome.

Background: Lumbar facet joint syndrome (LFJS) has been suggested to be a main source of low back pain. Methylene blue (MB), an inhibitor of nitric oxide synthesis with potential analgesic and anti-inflammatory properties, has been widely applied for a variety of pain-related diseases. However, no studies have been conducted on the treatment of LFJS patients using MB.

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology for which there are no approved therapeutic options. Patients with PSC display changes in gut microbiota and in bile acid (BA) composition; however, the contribution of these alterations to disease pathogenesis remains controversial. Here we identify a role for microbiota-dependent changes in BA synthesis that modulates PSC pathophysiology.

Three-Dimensional Finite Element Analysis of L4-5 Degenerative Lumbar Disc Traction under Different Pushing Heights.

Objective: To study and analyze the changes of intervertebral foramen height and area of the degenerative L4-5 intervertebral disc under different pushing heights by the finite element method.

Methods: CT and MRI images of T12-S1 segments were obtained from a healthy volunteer who met the inclusion criteria. A DR machine was used to capture images of the lumbar lateral section before and after simultaneous pushing of the L4 and L5 spinous processes by manipulation called Daogaijinbei, and the measurement showed that the displacement changes of L4 and L5 were both approximately 10 cm, so the pushing height was set at 0-10 cm.

Translational Attenuation Mechanism of Induction by Erythromycin Is Dependent on Two Leader Peptides.

Ribosome stalling on at the tenth codon (Asp) is believed to be a major mechanism of induction by erythromycin (Ery). In this study, we demonstrated that the mechanism of induction by Ery depends not only on expression but also on previously unreported expression. Introducing premature termination codons in , we proved that translation of the N-terminal region of is the key component for induced by Ery, whereas translation of the C-terminal region of did not affect Ery-induced .