Biofilm Formation, Motility, and Virulence of Are Reduced by Deletion of the Gene , a Novel Listerial LPXTG Surface Protein.

Listeria monocytogenes () is a foodborne pathogen that causes listeriosis in humans and other animals. Surface proteins with the LPXTG motif have important roles in the virulence of . Lmo0159 is one such protein, but little is known about its role in virulence, motility, and biofilm formation.

EⅡB Mutation Reduces the Pathogenicity of by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression.

To explore the role of the membrane permease ⅡB (EⅡB) gene of pathogenicity island 4 (LIPI-4) in the virulence of , both an EⅡB deletion strain (∆EⅡB) and a complemented strain were constructed. In vitro experiments demonstrated that EⅡB deletion affected the biofilm formation ability of the wild-type strain (Lm928). Moreover, this deletion decreased the intracellular proliferation abilities of .