Continuous renal replacement therapy without anticoagulation in critically ill patients at high risk of bleeding: A systematic review and meta-analysis.

The current clinical guideline recommends continuous renal replacement therapy (CRRT) proceed without anticoagulation in patients with contraindication to citrate and increased bleeding risk. Nevertheless, the efficacy of anticoagulation-free CRRT remains inconsistent. The purpose of our present systematic review is to evaluate the efficacy and safety of anticoagulant-free CRRT based on the current literatures.

The complete mitochondrial genome of a Green macroalgae species: (Ulvales: Ulvaceae).

a green macroalgae, is one of the causal species for green tides in Japan and spread into the coast of China. During this research, we sequenced the complete mitochondrial genome of . The mitogenome is 62,887 bp in length, including 28 encoding genes and 29 tRNA genes.

Emergency preparedness for heat illness in China: A cross-sectional observational study.

Background: The morbidity and mortality rates from heat illness have increased due to a higher number of heatwaves. Effective urgent care of heat illness is crucial for optimizing patient outcomes. However, few studies have examined the emergency preparedness measures required for treating such patients.

[48,XXYY syndrome: A report of four cases].

Objective: To explore the clinical characteristics and prognosis of the 48,XXYY syndrome and gain a deeper insight into this condition.

Methods: This retrospective study included 4 cases of 48,XXYY syndrome confirmed between 2011 and 2018. We analyzed the general information, clinical manifestations, laboratory results, imaging features and outcomes of assisted reproductive technology (ART) of the patients and reviewed the relevant literature.

Response of soil microbial communities to engineered nanomaterials in presence of maize (Zea mays L.) plants.

With the intended application of engineered nanomaterials (ENMs) in agriculture, accurate assessment the effect of these ENMs on soil microbial communities is especially necessary. Here, maize plants were cultivated in soil amended by SiO, TiO, and FeO ENMs (100 mg kg soil) for four weeks. The impact of ENMs on bacterial community structure of the rhizosphere soil was investigated by using high-throughput sequencing.

Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus.

Background: Genome-wide association studies (GWASs) have reported hundreds of genomic loci associated with schizophrenia, yet identifying the functional risk variations is a key step in elucidating the underlying mechanisms.

Methods: We applied multiple bioinformatics and molecular approaches, including expression quantitative trait loci analyses, epigenome signature identification, luciferase reporter assay, chromatin conformation capture, homology-directed genome editing by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/Cas9), RNA sequencing, and ATAC-Seq (assay for transposase-accessible chromatin using sequencing).

Results: We found that the schizophrenia GWAS risk variations at 16p11.

Determination of trace polycyclic aromatic hydrocarbons in water and milk using solid-phase extraction packed with graphene/chitosan composite aerogel prior to gas chromatography-mass spectrometry.

Polycyclic aromatic hydrocarbons, ubiquitous compounds that result from incomplete combustion or pyrolysis of natural and man-made combustion sources, can adversely affects human health due to their well-known toxicity. This paper demonstrates the significant potential of graphene/chitosan composite aerogels as solid-phase extraction sorbents for efficient polycyclic aromatic hydrocarbon extraction and material for the highly sensitive analysis in environmental samples using gas chromatography-mass spectrometry in selective ion monitoring mode. Under the optimal condition, samples spiked with polycyclic aromatic hydrocarbons were determined at the pg/mL level in different aqueous sample matrices, including tap water, river water, and milk.

Low Concentrations of Silver Nanoparticles and Silver Ions Perturb the Antioxidant Defense System and Nitrogen Metabolism in N-Fixing Cyanobacteria.

Although toxic effects of silver nanoparticles (AgNPs) on aquatic organisms have been extensively reported, responses of nitrogen-fixing cyanobacteria to AgNPs/Ag under environmentally relevant concentrations are largely unknown. Here, cyanobacteria were exposed to different concentrations of AgNPs (0.01, 0.

Comparation of the phytotoxicity between chemically and green synthesized silver nanoparticles.

Green synthesis of silver nanoparticles (Ag NPs) by using plants extracts has provided an eco-friendly alternation for industry and agriculture application. Here, we prepared Ag NPs by using the cucumber leaves and rice husk extracts, and further assessed the antimicrobial activity and phytotoxicity of green synthesized Ag NPs (g-Ag NPs) comparing with chemically synthesized Ag NPs (chem-Ag NPs). The chem-Ag NPs had strong antibacterial activity on the growth of Escherichia coli, while g-Ag NPs by rice husks (gr-Ag NPs) exhibited long-term antibacterial effects.

PKM2-dependent glycolysis promotes skeletal muscle cell pyroptosis by activating the NLRP3 inflammasome in dermatomyositis/polymyositis.

Objectives: Muscle cell necrosis is the most common pathological manifestation of idiopathic inflammatory myopathies. Evidence suggests that glycolysis might participate in it. However, the mechanism is unclear.

Regional citrate anticoagulation vs no-anticoagulation for CRRT in hyperlactatemia patients with increased bleeding risk: A retrospective cohort study.

There are controversial opinions on the use of regional citrate anticoagulation (RCA) continuous renal replacement therapy (CRRT) in hyperlactatemia patients with increased bleeding risk. Patients with hyperlactatemia and increased bleeding risk who accepted RCA or no-anticoagulation CRRT in our center were retrospectively included. Eighty patients who underwent RCA-CRRT and 47 patients received no-anticoagulation CRRT were included.

Correction: Potent and specific MTH1 inhibitors targeting gastric cancer.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

[Association of maternal diabetes mellitus and UCP2 gene polymorphisms with congenital heart disease in offspring: a case-control study].

Objective: To study the association of maternal diabetes mellitus (DM), uncoupling protein 2 (UCP2) gene polymorphisms, and their interaction with the risk of congenital heart disease (CHD) in offspring.

Methods: A hospital-based case-control study was conducted. A total of 464 mothers of children with CHD alone who were diagnosed in Hunan Children's Hospital from March 2018 to August 2019 were enrolled as the case group.

Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella).

The red blood cells (RBCs) of fish make up around 95% of the total peripheral blood cells, and the long-held paradigm is that RBCs are mainly responsible for transporting oxygen. Previous studies have showed that the RBCs can be involved in the immune response against bacterial infection; however, this mechanism remains enigmatic. Here, we explored the structure of grass carp RBCs (GcRBCs).

[Improvement of Dystonia after Spinal Cord Injury by Applying Repetitive Transcranial Magnetic Stimulation on the Premotor Cortex: Case Report].

This article reports a patient with spinal cord injury who was treated with conventional rehabilitation therapy plus repeated transcranial magnetic stimulation (rTMS) during the postoperative rehabilitation, and to observe the effects of rTMS on dystonia. A 66-year-old male patient fell from the bed 8 months ago. At that time, he felt pain in his neck, dysfunction in limbs movement, and loss of sensation in trunk and limbs.

Foliar Application of SiO Nanoparticles Alters Soil Metabolite Profiles and Microbial Community Composition in the Pakchoi ( L.) Rhizosphere Grown in Contaminated Mine Soil.

Silica nanoparticles (SiO-NPs) are promising in nanoenabled agriculture due to their large surface area and biocompatible properties. Understanding the fundamental interaction between SiO-NPs and plants is important for their sustainable use. Here, 3 week-old pakchoi ( L.

Numerical study of mass transfer and desorption behaviors in deformable porous media using a coupling lattice Boltzmann model.

The aim of this paper is to investigate the pore-scale mass transfer and desorption behaviors in deformable porous media using a coupling immersed boundary method (IBM)-lattice Boltzmann (LB) scheme. In this numerical model, a three-dimensional multiple-relaxation-time LB model is used to simulate fluid flow in porous media consisting of movable rigid adsorbent particles. To consider the effect of dynamic deformation of a porous structure, an improved immersed boundary method scheme is introduced to describe the fluid-structure interaction at the interface between the carrier gas and moving absorbent particles.

Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota.

Aims: Studies have shown that destruction of the intestinal barrier in type 2 diabetes (T2D) leads to increased absorption of macromolecules from intestinal. We previously exhibited that short-chain fatty acids (SCFAs) and bile acids (BAs) were significantly decreased in faeces of T2D patients. In the current study, we extended these findings by focusing on the interactions between intestinal barrier and clinical characteristics, gut microbiota, SCFAs and BAs.

Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation.

Background: Ubiquitin specific peptidase 8 (USP8) has been reported to induce the degradation of several receptor tyrosine kinases such as epidermal growth factor receptor (EGFR), among which human epidermal growth factor receptor-3 (HER-3) is one of them. However, the role and functional mechanisms of USP8 and HER-3 in gastric cancer (GC) remain unknown.

Objective: To explore the function and mechanism of USP8 and HER-3 in the progression of GC.

Association of maternal dietary intakes and CBS gene polymorphisms with congenital heart disease in offspring.

Background: Although it is generally acknowledged that genetic and environmental factors are associated with risk of congenital heart disease (CHD), the causes are not fully understood. This study aimed at assessing the association of maternal dietary intakes, genetic variants of cystathionine beta synthase (CBS) gene and their interactions with risk of CHDs in offspring.

Method: A hospital-based case-control study of 464 mothers with CHD infants and 504 control mothers of health infant was performed.

Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans in recent years, whereas its genetic basis in other populations remains relatively less understood. We herein report that the leading risk locus for BD in European genome-wide association studies (GWAS), the single-nucleotide polymorphism (SNP) rs9834970 near TRANK1 at 3p22 region, is also genome-wide significantly associated with BD in a meta-analysis of four independent East Asian samples including 5748 cases and 65,361 controls (p = 2.27 × 10, odds ratio = 1.

Effects of nano-enabled agricultural strategies on food quality: Current knowledge and future research needs.

It is becoming more feasible to use nano-enabled agricultural products such as nanofertilizers and nanopesticides to improve the efficiency of agrochemical delivery to crop plants. Experimental results have shown that nano-agrochemicals have great potential for reducing the environmental impact of traditional agrochemicals while simultaneously significantly increasing crop production. However, emerging data suggest that nano-enabled products are not only capable of increasing yield, but also result in alterations in crop quality.