Ultra-stretchable, self-recoverable, notch-insensitive, self-healable and adhesive hydrogel enabled by synergetic hydrogen and dipole-dipole crosslinking.

Hydrogels are promising materials for wearable electronics, artificial skins and biomedical engineering, but their limited stretchability, self-recovery and crack resistance restrict their performance in demanding applications. Despite efforts to enhance these properties using micelle cross-links, nanofillers and dynamic interactions, it remains a challenge to fabricate hydrogels that combine high stretchability, self-healing and strong adhesion. Herein, we report a novel hydrogel synthesized the copolymerization of acrylamide (AM), maleic acid (MA) and acrylonitrile (AN), designed to address these limitations.

Advances and challenges of prenatal interventions for fetal tachyarrhythmias.

It is estimated that 1%-2% of pregnancies are complicated by fetal arrhythmias, with most arrhythmias considered benign and not requiring further treatment or intervention. However, persistent tachyarrhythmias can lead to fetal heart failure, preterm birth, stillbirth, and increased risks during the perinatal period. Therefore, timely treatment during pregnancy is often necessary.

The dynamic characteristics of the shearer cable drag system.

Based on the 5615 working face of Beisu Coal Mine, a virtual prototype of the shearer cable drag system was developed using the MG2×70/325-BWD electric traction shearer as the carrier, in combination with CERO and ADAMS software. The shearer cable was equivalently modeled using the discrete rigid body method to study the dynamic characteristics of the drag system. This research provides a foundation for the design and optimization of both the cable and cable clamps.

Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy.

Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in the deterioration of renal cells such as podocytes and tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, represents a spectrum of cell demise processes intricately governed by genetic mechanisms in vivo. Under physiological conditions, PCD facilitates the turnover of cellular populations and serves as a protective mechanism to eliminate impaired podocytes or tubular epithelial cells, thereby preserving renal tissue homeostasis amidst hyperglycemic stress.

Dynamic characteristics and fatigue life analysis of the gyration platform of roadheader.

In order to investigate the dynamic characteristics and fatigue life of the roadheader's gyration platform during the cutting process, the calculation of the cutting head load was achieved based on the force and its transformation of cutting pick, and the transient loads in the two lateral swing directions of the roadheader were calculated. Subsequently, the simulated load was applied to the multi-body model of the cutting section, and dynamic simulations were conducted. Critical information, including stress and strain distribution, as well as the maximum stress on the gyration platform, was extracted from these simulations.

Optimal duration of progesterone before cryopreserved embryo transfer in hormone replacement therapy cycles: A prospective pilot study.

This prospective pilot cohort study aimed to ascertain the optimal duration of progesterone supplementation prior to frozen embryo transfer (FET) in women undergoing hormone replacement therapy (HRT) cycles. A total of 127 participants were enrolled and divided into 2 cohorts. The first cohort, comprising of 39 women, was used to determine the peak period of endometrial receptivity.

Unlocking the dual role of LSD1 in tumor immunity: innate and adaptive pathways.

The roles of innate and adaptive immunity are crucial in both the development of cancer and its response to treatment. Numerous studies have demonstrated that histone lysine-specific demethylase 1 (LSD1) is overexpressed in various cancers. Elevated levels of LSD1 intricately modulate immune checkpoints, the function of immune cells, and the expression of immunomodulators, impacting both innate and adaptive immunity.

Prognostic effectiveness of interactive vs. non-interactive mobile app interventions in type 2 diabetes: a systematic review and meta-analysis.

Background: Mobile app interventions are emerging as significant tools in managing the prognosis of type 2 diabetes, demonstrating progressively greater impacts. The effectiveness of these interventions needs further evidence-based support.

Objective: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the effectiveness of mobile app interventions in improving prognosis for patients with type 2 diabetes.

Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury.

Astrocytes derive from different lineages and play a critical role in neuropathic pain after spinal cord injury (SCI). Whether selectively eliminating these main origins of astrocytes in lumbar enlargement could attenuate SCI-induced neuropathic pain remains unclear. Through transgenic mice injected with an adeno-associated virus vector and diphtheria toxin, astrocytes in lumbar enlargement were lineage traced, targeted, and selectively eliminated.

Association between eating rate and childhood overweight/obesity: a systematic review and meta-analysis.

Many studies have reported the relationship between eating rate and childhood overweight/obesity, while results remain inconclusive. The present study was done to estimate the association between eating rate and childhood overweight/obesity through a systematic review of prevalence studies. Relevant studies were searched by two independent researchers in databases including PubMed, Embase, Cochrane Library, and Web of Science, and data were collected from relevant studies published through June 2023 using predefined inclusion/exclusion criteria.

Research on coal rock parameter calibration based on discrete element method.

To ensure that the discrete element model of the coal wall accurately reflects the actual cutting process of coal and rock during virtual prototype simulation of mining equipment, this study aims to expedite the development of intelligent mining machinery. Using coal samples from the 4602 working face of Yangcun Coal Mine, operated by Yanzhou Coal Mining Group, we conducted coal rock packing experiments and uniaxial compression tests to obtain the packing angle and compressive strength of the coal samples. Based on the experimental results, we designed Plackett-Burman experiments (PB experiments), steepest ascent experiments, and Box-Behnken experiments to study the influence of particle contact mechanics parameters and bonding mechanics parameters on the packing angle and compressive strength, using the packing angle and compressive strength as response variables.

Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling.

Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food-drug interactions (FDIs) between piperine and CYP3A4 substrate drugs using these models. The PBPK model for piperine was successfully developed and validated.

Prevalence and risk factors of myopia among children and adolescents in Hangzhou.

To analyze the prevalence and influencing factors of myopia among children and adolescents in Hangzhou city, and provide ideas for the formulation of myopia prevention and control measures. A cross-sectional school-based study using stratified cluster random sampling method was used to select 31,880 students from 113 schools in Hangzhou city. Myopia screening and questionnaires on the influencing factors of poor visual acuity were carried out.

Retrotransposon involves in photoperiodic spermatogenesis in Brandt's voles (Lasiopodomys brandtii) by co-transcription with flagellar genes.

Photoperiod is a pivotal factor in affecting spermatogenesis in seasonal-breeding animals. Transposable elements have regulatory functions during spermatogenesis. However, whether it also functions in photoperiodic spermatogenesis in seasonal breeding animals is unknown.

Photoelectron Spectroscopy and Theoretical Studies on the Structures and Properties of GeC and GeCH Clusters.

We investigate the structures and properties of GeC and GeCH clusters using anion photoelectron spectroscopy and theoretical calculations. Our calculations show that the first two low-lying isomers coexist in the experiments of GeC and GeCH. The first two low-lying isomers of GeC have trigonal bipyramidal structures with the C atom on the equatorial plane and the top vertex, respectively.

Circ_0015382 Regulates the miR-942-5p/NDRG1 Axis to Suppress Trophoblast Cell Functions.

Circular RNAs (circRNAs) are non-coding RNAs that exert vital function in many human diseases, including preeclampsia (PE). Circ_0015382 is considered to be a key regulator of PE progression, so more molecular mechanisms need to be further studied. Real-time quantitative PCR was used to detect the mRNA levels of circ_0015382, miR-942-5p, and N-myc downstream regulated 1 (NDRG1).

The lncRNA CADM2-AS1 promotes gastric cancer metastasis by binding with miR-5047 and activating NOTCH4 translation.

Background: Multi-organ metastasis has been the main cause of death in patients with Gastric cancer (GC). The prognosis for patients with metastasized GC is still very poor. Long noncoding RNAs (lncRNAs) always been reported to be closely related to cancer metastasis.

[Comparison and application of obesity screening indicators in children and adolescents aged 6-18 years in Hangzhou in 2023].

Objective: To determine the percentile reference values and reference curves of total body fat percentage in children and adolescents by sex and age, and to evaluate the reliability of different anthropometric indicators in screening for obesity in children and adolescents in order to explore the validity and practicality of a large-scale screening tool for childhood obesity and its desirable thresholds.

Methods: A total of 5983 children and adolescents aged 6-18 years from six primary and secondary schools were selected by stratified randomised cluster sampling in Hangzhou City in 2023, and their weight, height, waist and hip circumferences were measured, and the children's total body fat content was measured using the bioelectrical resistance-antibody composition analyser. A generalised additive model(GAMLSS) was used to construct a percentile reference curve for children's body fat percentage, and the performance of each anthropometric measure in correctly classifying children and adolescents as obese was assessed using receiver operating characteristic(ROC) curves.

Recovery technology of spent hydrogenation catalysts -A review.

Spent hydrogenation catalysts (HDCs) contain many Mo, V, Co, Ni, and AlO carriers, which are valuable secondary resources. However, improper disposal can also lead to environmental pollution risks. In the past decade, research reviews on the recovery of valuable metals from spent HDCs have been somewhat reported, mainly summarizing basic technical processes.

"Two zones and three centers" distribution and suitable areas shift of an evergreen oak in subtropical China under climate scenarios.

Understanding the impact of climate change on the geographical distribution of species is a fundamental requirement for biodiversity conservation and resource management. , an evergreen oak endemic to China, plays a crucial role in maintaining the ecological stability in subtropical regions and high economic value attributed to its dark and high-density heartwood, but the existing resources are close to endangered. Currently, limited knowledge exists regarding its distribution and potential influences of climate change on suitable areas.

Non-invasive TMS attenuates neuropathic pain after spinal cord injury associated with enhancing brain functional connectivity and HPA axis activity.

Patients with spinal cord injury (SCI) often suffer from varying degrees of neuropathic pain. Non-invasive repetitive transcranial magnetic stimulation (TMS) has been shown to improve neuropathic pain, while the appropriate intervention strategies of TMS treatment and how TMS affects brain function after SCI were not entirely clear. To investigate the effects and mechanisms of TMS on neuropathic pain after SCI, high-frequency TMS on primary motor cortex (M1) of mice was performed after SCI and pain response was evaluated through an electronic Von-Frey device and cold/hot plates.

Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut-Liver-Brain Axis.

Oxyresveratrol is a stilbene compound with a simple chemical structure and various therapeutic potentials. This study summarized and analyzed the multiple pharmacological effects and mechanisms of oxyresveratrol, identifying its prominent performance in neuroprotection, hepatoprotection, and anti-inflammatory activities in the intestines. By integrating the pharmacological effects of oxyresveratrol with insights from the network pharmacology and molecular docking of its interactions with targets linked to gut-liver-brain axis disorders, it has been shown that oxyresveratrol may hold promise for the treatment of gut-liver-brain axis-related disorders.

Regional citrate anticoagulation versus LMWH anticoagulation for CRRT in liver failure patients without increased bleeding risk.

Background: The optimal anticoagulation regimen for continuous renal replacement therapy (CRRT) in liver failure (LF) patients without increased bleeding risk remains controversial. Therefore, we conducted a monocentric retrospective study to evaluate the efficacy and safety of the regional citrate anticoagulation (RCA) versus low molecular weight heparin (LMWH) anticoagulation for CRRT in LF without increased bleeding risk.

Method: According to the anticoagulation strategy for CRRT, patients were divided into the RCA and LMWH-anticoagulation groups.