Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis.

Kinesin family member 20B (KIF20B, also known as MPHOSPH1) is a kinesin protein that plays a critical role in cytokinesis. Previously, we and others have demonstrated the oncogenic role of KIF20B in several cancers; however, the exact mechanisms underlying its tumorigenic effects remain unclear. Herein, we showed overexpression of KIF20B in human hepatocellular carcinoma (HCC) and reported a negative correlation between KIF20B level and prognosis of patients.

Reducing protein regulator of cytokinesis 1 as a prospective therapy for hepatocellular carcinoma.

Proteins that bind to microtubule are important for cell cycle, and some of these proteins show oncogenic characteristics with mechanisms not fully understood. Herein we demonstrate overexpression of protein regulator of cytokinesis 1 (PRC1), a microtubule-associated regulator of mitosis, in human hepatocellular carcinoma (HCC). Moreover, upregulated PRC1 is associated with lower survival rates of HCC patients.

The bis(p-sulfonatophenyl)phenylphosphine-assisted synthesis and phase transfer of ultrafine gold nanoclusters.

Gold nanoclusters (Au NCs) have attracted intensive attention for their molecular-like properties such as luminescence and unique charging behavior. A facile route has been developed for the preparation of ultrafine Au NCs at room temperature. Bis(p-sulfonatophenyl)phenylphosphine dihydrate dipotassium was used to stabilize the Au NCs obtained by NaBH(4) reduction of HAuCl(4) at pH of ∼12 and facilitated the phase transfer of Au NCs from aqueous phase to an organic medium based on electrostatic interaction.