mRNA-Based Cancer Vaccines: Advancements and Prospects.

The success of mRNA COVID-19 vaccines has reinvigorated research and interest in mRNA-based cancer vaccines. Despite promising results in clinical trials, therapeutic mRNA-based cancer vaccines have not yet been approved for human use. These vaccines are designed to trigger tumor regression, establish enduring antitumor memory, and mitigate adverse reactions.

Narrow laser linewidth measurement with the optimal demodulated Lorentzian spectrum: erratum.

This erratum corrects errors in Fig. 4(b) of the original paper, Appl. Opt.

Narrow laser linewidth measurement with the optimal demodulated Lorentzian spectrum.

A method called the optimal demodulated Lorentzian spectrum is employed to precisely quantify the narrowness of a laser's linewidth. This technique relies on the coherent envelope demodulation of a spectrum obtained through short delayed self-heterodyne interferometry. Specifically, we exploit the periodic features within the coherence envelope spectrum to ascertain the delay time of the optical fiber.

Development of a New Limiting-Antigen Avidity Dot Immuno-Gold Filtration Assay for HIV-1 Incidence.

Several laboratory assays on cross-sectional specimens for detecting recent HIV infections were developed, but these assays could not be applied in resource-limited and high HIV-incidence areas. This study describes the development of a rapid assay that can simultaneously detect the presence of HIV-1 antibodies of current and/or recent infection. The dot immuno-gold filtration assay (DIGFA) was used to detect recent infection on the principle of antibody avidity changes between recent and long-term infections.