Publications by authors named "Lijie You"
Introduction: Kinesin family member 20A (KIF20A) is essential for cell proliferation and is implicated in promoting tumor progression, but its role in hepatocellular carcinoma (HCC) remains poorly studied.
Methods: Through the analysis of bulk RNA-sequencing (bulk RNA-seq) and single-cell RNA sequencing (scRNA-seq) data, the expression of KIF20A and its relationship with diagnosis, prognosis, and the immune microenvironment were examined. The association between KIF20A and the malignant progression and metastasis of HCC was confirmed through and experiments.
Immunotherapy has become a primary and secondary treatment for gastric cancer (GC) patients with mismatch repair deficiency (dMMR), and is used in both perioperative and advanced stages. The tumor immune microenvironment (TiME) is crucial for immunotherapy efficacy, yet the impact of MMR status on TiME remains understudied. We employed single-cell RNA sequencing (scRNA-seq) to analyze 33 fresh tissue samples from 25 patients, which included 10 normal tissues, 6 dMMR tumor tissues, and 17 pMMR tumor tissues, aiming to characterize the cellular and molecular components of the TiME.
View Article and Find Full Text PDFArticle Synopsis
- Hepatocellular carcinoma (HCC) is a serious cancer with late diagnosis and poor outcomes; this study focused on creating a gene signature to improve prognosis prediction.
- Using machine learning on multiple patient cohorts, researchers identified 119 key genes, narrowing it down to a four-gene signature that effectively predicts survival and treatment response.
- The study establishes the HCC prognosis-related gene signature (HPRGS) as a valuable tool for guiding treatment decisions and improving survival rates in HCC patients.
Small cell lung cancer (SCLC) is a very aggressive tumor. Abnormal expression of BUB1 has been reported in several cancer types, wherein it plays a range of functional roles. This work aimed to elucidate the functional significance and molecular impacts of BUB1 in SCLC.
View Article and Find Full Text PDFArticle Synopsis
- HMMR is found to be overexpressed in hepatocellular carcinoma (HCC) tissues, indicating its potential role as a diagnostic marker and a factor influencing cancer progression.
- Research methodologies included differential expression analysis, intercellular communication assessment, and various assays to study HMMR's effects on HCC cell behaviors like proliferation and migration.
- High levels of HMMR correlate with poor patient prognosis and genomic heterogeneity, suggesting that targeting HMMR could improve treatment outcomes and aid in predicting responses to therapies such as immunotherapy.
α-Enolase (ENO1) is a crucial molecular target for tumor therapy and has emerged as a research hotspot in recent decades. Here, we aimed to explore the role of ENO1 in bladder cancer (BLCA) and then construct a signature to predict the prognosis and treatment response of BLCA. Firstly, we found ENO1 was highly expressed in BLCA tissues, as verified by IHC, and was associated with poor prognosis.
View Article and Find Full Text PDF