Enhancer of Zeste Homolog 2 Protects Mucosal Melanoma from Ferroptosis via the KLF14-SLC7A11 Signaling Pathway.

Background: Mucosal melanoma (MM) is epidemiologically, biologically, and molecularly distinct from cutaneous melanoma. Current treatment strategies have failed to significantly improve the prognosis for MM patients. This study aims to identify therapeutic targets and develop combination strategies by investigating the mechanisms underlying the tumorigenesis and progression of MM.

Prognostic Prediction and Immune Microenvironment Characterization in Uveal Melanoma: A Novel Mitochondrial Metabolism-Related Gene Signature.

Uveal Melanoma (UM), a highly aggressive and metastatic intraocular cancer with a strong propensity for liver metastasis, presents limited therapeutic alternatives and unfavorable survival outcomes. Despite its low incidence, the underlying mechanisms of UM pathogenesis and the precise role of mitochondrial metabolism in UM remain inadequately understood. Utilizing Cox proportional hazards regression analysis was used to assess prognostic relevance, and consensus clustering was employed for molecular subtyping.

Compact and efficient photonic lanterns through multi-stage tapering.

Photonic lanterns (PLs) have been recently used in mode-division multiplexed systems with a low insertion loss, a low mode-dependent loss (MDL), and a wide bandwidth. However, the cross talk (XT) performance of the PLs requires further enhancement within a short taper length. In this Letter, a multi-stage cascaded scheme for short PLs is proposed to further improve the performance on losses and XT.

Serum analysis based on SERS combined with 2D convolutional neural network and Gramian angular field for breast cancer screening.

Breast cancer is a significant cause of death among women worldwide. It is crucial to quickly and accurately diagnose breast cancer in order to reduce mortality rates. While traditional diagnostic techniques for medical imaging and pathology samples have been commonly used in breast cancer screening, they still have certain limitations.

Congenital adrenal hyperplasia disorder due to 17 α-hydroxylase deficiency: a case report.

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder with a related enzyme deficiency involved in the adrenal corticosteroid synthesis pathway due to genetic mutations. 17α-hydroxylase deficiency(17α-OHD) is a rare form of CAH. Herein, we reported clinical data on diagnosis and treatment regimens for a 17α-hydroxylase-deficient patient.

Spectacle lenses with slightly aspherical lenslets for myopia control: clinical trial design and baseline data.

Objectives: Myopia is a major public health problem and it is essential to find safe and effective means to control its progression. The study design and baseline data are presented for a one-year prospective, double-masked, crossover, randomized clinical trial evaluating the efficacy of single vision spectacle lenses with concentric rings of slightly aspherical contiguous lenslets technology (SAL) on myopia control.

Methods: One hundred 8- to 13-year old Chinese children with a refractive error of -0.

The association of obesity with thyroid carcinoma risk.

Background: The prevalence of obesity and an increased incidence of thyroid carcinoma (TC) threaten public health in parallel on a global scale. Sufficient evidence supports excess body fatness in thyroid carcinogenesis, and the role and anthropometric markers of obesity have been causally associated with the rising risk of TC.

Methods: A literature search was conducted in PubMed.

Macular perfusion density evaluation in constant and intermittent exotropia by means of optical coherence tomography angiography.

Background: To quantify and compare retinal microvascular features using optical coherence tomography angiography (OCTA) in constant (XT) and intermittent exotropia (IXT).

Methods: An observational cross-sectional study was conducted from September 2020 to November 2020 at the Affiliated Eye Hospital of Wenzhou Medical University. OCTA examination was performed to evaluate the macular perfusion density of the deep capillary plexus (DCP), superficial capillary plexus (SCP), and foveal avascular zone (FAZ) parameters in XT and IXT patients, and in age-matched controls.

Application of multi-active center organic quinone molecular functionalized graphene in fully pseudocapacitive asymmetric supercapacitors.

5, 7, 12, 14-pentacenetetrone (PT), polycyclic quinone derivatives, are rich in carbonyl, which were investigated as a novel organic electrode material for supercapacitors. PT with aconjugated system, is a flat molecule, generating strong-interactions between molecules. PT molecules were uniformly fixed on conductive reduced graphene oxide (rGO) through-interaction by one-step solvothermal method, forming a three-dimensional cross-linked PT@rGO hydrogel.

2-Amino-3-chloro-1,4-naphthoquinone-covalent modification of graphene nanosheets for efficient electrochemical energy storage.

Green and renewable organic redox molecules are greatly advantageous over conventional inorganic intercalation electrode materials in terms of electrochemical reversibility and cycling stability. However, their electrical insulation prevents them from being used alone as electrode materials for supercapacitors. Herein, 2-amino-3-chloro-1,4-naphthoquinone (ACNQ) molecules were covalently grafted onto graphene nanosheets (GNS) via diazotization.

Hierarchically porous and heteroatom self-doped graphitic biomass carbon for supercapacitors.

Here we report a simple, low-cost and environment friendly method, in which Black locust seed dregs and potassium ferrate (KFeO) are used as starting raw materials and activation agent. The hierarchically porous carbons (BDPC) with high special surface area and abundant mesopores (S = 2010.1 m g and V = 1.

Measurement of the limbus-insertion distance in adult strabismus patients with anterior segment optical coherence tomography.

Purpose: To determine the ability of the anterior segment optical coherence tomography (AS-OCT) in measuring the distance from the corneoscleral limbus to the insertion site of the horizontal extraocular muscles in adult patients with strabismus.

Methods: A total of 16 strabismus patients were recruited for this study. The limbus-insertion distances of the horizontal rectus muscles were measured with AS-OCT preoperatively and calipers intraoperatively.

Cycloplegic and noncycloplegic refractions of Chinese neonatal infants.

Purpose: To examine Chinese neonatal infants with both cycloplegic and noncycloplegic retinoscopy and to compare the distribution of refractive errors for the two techniques.

Methods: Cycloplegic retinoscopy was performed by two experienced pediatric ophthalmologists on 81 neonatal infants randomly selected from a group of 185 neonates who had undergone noncycloplegic retinoscopy. All infants were between 1 day and 6 days of age and were born without incident at full term.