2-week prevalence and associated factors of fever, diarrhea, and coexisting fever and diarrhea among children aged 6-23 months in rural Hunan Province.

Fever and diarrhea are key causes of malnutrition, growth and development disorders, and death among children. At present, most studies on the associated factors of fever and diarrhea in children are concentrated in African and South Asian countries, but relevant research in China is very limited. This study was aimed to analyze the two-week prevalence of fever, diarrhea, and coexisting fever and diarrhea among children aged 6-23 months in rural areas of Hunan Province and to explore the associated factors.

The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma.

Background: Ubiquitin/ubiquitin-like (Ub/UBL)-related genes have been reported to be associated with the survival of osteosarcoma patients but have not yet been systematically explored.

Methods: The prognostic value of Ub/UBL-related genes, immune cell infiltration and clinicopathological features of patients were explored by Cox and LASSO regression analyses. A prognostic model was established and then validated in the GSE21257 dataset.

Prognostic value of PRR11 and immune cell infiltration in Ewing sarcoma.

Ewing's sarcoma (ES) is the second most common bone and soft tissue malignancy in children and adolescents with a poor prognosis. The identification of genes with prognostic value may contribute to the prediction and treatment of this disease. The GSE17679, GSE68776, GSE63155, and GSE63156 datasets were downloaded from the Gene Expression Omnibus database and qualified.

TiB and SrB monolayers: high capacity and zero strain-like anode materials for Li/Na/K/Ca ion batteries.

Storage capacity, average open circuit voltage (OCV), diffusion barrier, lattice parameter changes, are key indicators of whether a material would be suitable for use as a Li-ion or non-Li-ion battery (LIB or NLIB) anode. The rapid development of 2D materials over the past few decades has opened up new possibilities for these metrics. Using first-principles calculations, we prove that two 2D materials, TiB and SrB, show excellent performance in terms of the above metrics when used as anodes for LIBs or NLIBs.

Prognostic value of and infiltrating immune cells in Ewing sarcoma.

Background: The prognostic value of D-glucuronyl C5-epimerase ( and mast cell infiltration in Ewing sarcoma (ES) has not been well specified and highlighted, which may facilitate survival prediction and treatment.

Methods: Several qualified datasets were downloaded from the GEO website. Common differentially expressed genes between normal subjects and ES patients in GSE17679, GSE45544, and GSE68776 were identified and screened by multiple algorithms to find hub genes with prognostic value.

Efficacy and safety of CM310 in severe eosinophilic chronic rhinosinusitis with nasal polyps (CROWNS-1): a multicentre, randomised, double-blind, placebo-controlled phase 2 clinical trial.

Background: Severe eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) remains the most relapsed subtype of uncontrolled CRSwNP. CM310, a humanised anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits IL-4 and IL-13 signaling which underlying eosinophilic inflammation. This study aims to evaluate the efficacy and safety of CM310 in patients with severe ECRSwNP.

Docosahexaenoic acid improves cognition and hippocampal pyroptosis in rats with intrauterine growth restriction.

Background And Objective: Intrauterine growth restriction (IUGR) is defined as the failure of a fetus to reach its genetic growth potential in utero resulted by maternal, placental, fetal, and genetic factors. Previous studies have reported that IUGR is associated with a high incidence of neurological damage, although the precise causes of such damage remain unclear. We aimed to investigate whether cognitive impairment in rats with IUGR is related to pyroptosis of hippocampal neurons and determine the effect of early intervention with docosahexaenoic acid (DHA).

Novel peripheral blood diagnostic biomarkers screened by machine learning algorithms in ankylosing spondylitis.

Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown etiology that is hard to diagnose early. Therefore, it is imperative to explore novel biomarkers that may contribute to the easy and early diagnosis of AS. Common differentially expressed genes between normal people and AS patients in GSE73754 and GSE25101 were screened by machine learning algorithms.

The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma.

Background: Ewing sarcoma (ES) is the second most common primary malignant bone tumor mainly occurring in children, adolescents and young adults with high metastasis and mortality. Autophagy has been reported to be involved in the survival of ES, but the role remains unclear. Therefore, it's necessary to investigate the prognostic value of autophagy related genes using bioinformatics methods.

Application of Electrocardiogram Localization during Peripherally Inserted Central Catheter Line Insertion into the Persistent Left Superior Vena Cava of Neonates.

Background: Most neonates with persistent left superior vena cava (PLSVC) have no clinical symptoms or hemodynamic changes, and this anomaly is only found during cardiac catheterization, pacemaker implantation, or central venous catheterization. Electrocardiogram (ECG) localization is helpful for the application of the peripherally inserted central catheter (PICC) technique in neonates with PLSVC.

Objective: To explore the characteristic waveforms of the P wave when a PICC under ECG localization is applied in neonates with PLSVC.

Mixing behavior of -terphenyl-3,5,3',5'-tetracarboxylic acid with trimesic acid at the solid-liquid interface.

The molecular self-assembly of carboxylic acid molecules on a solid surface plays an important role in understanding the nanoscale-precision construction of functional patterns. In this study, the mixing behavior of -terphenyl-3,5,3',5'-tetracarboxylic acid (TPTC) and trimesic acid (TMA) on a highly oriented pyrolytic graphite surface was studied by scanning tunneling microscopy (STM). The STM images show how the presence of a small percentage of TPTC molecules adsorbed onto TMA molecules can drastically change the on-surface self-assembly behavior of aromatic tetracarboxylic acid by initiating the nucleation and growth of a different polymorph.

Etiology, antimicrobial resistance, and risk factors of neonatal sepsis in China: a systematic review and meta-analysis from data of 30 years.

Objective: To evaluate the regional etiology, antimicrobial resistance (AMR) pattern, and risk factors in neonates with sepsis in China.

Methods: We performed a systematic review and meta-analysis by searching Medline, Embase, Scopus, and Web of Science in December 2020. Studies of neonatal sepsis from China published between 2011 and 2020 were included.

Mechanisms Underlying Neurologic Injury in Intrauterine Growth Restriction.

Intrauterine growth restriction is a condition that prevents normal fetal development, and previous studies have reported that intrauterine growth restriction is caused by adverse intrauterine factors. This condition affects both short- and long-term neurodevelopmental disorders. Studies have revealed that neurodevelopmental disorders can contribute to gray and white matter damage and decrease the brain volume of affected individuals.

Suppressing the oxygen-related parasitic reactions in NaTi(PO)-based hybrid capacitive deionization with cation exchange membrane.

The parasitic reactions leading to capacity fading and charge loss remain a serious issue for capacitive deionization (CDI). NaTi(PO) (NTP) has recently emerged as a promising faradaic cathode in hybrid CDI (HCDI) with high Na uptake capacity and good Na selectivity, but it is still challenged by serious parasitic reactions. Although the irreversible faradaic reactions on carbon electrode are raising growing attention in CDI research field, the parasitic reactions on faradaic materials are seldom studied in HCDI by now.

Construction of two-dimensional bimetal (Fe-Ti) oxide/carbon/MXene architecture from titanium carbide MXene for ultrahigh-rate lithium-ion storage.

The development of battery systems with high specific capacity and power density could fuel various energy-related applications from personal electronics to grid storage. (FeTi)O possessing high theoretical specific capacity has been considered as a promising high rate anode material for lithium ion batteries due to the replacement of Fe (0.64 Å) by Ti (0.

A longitudinally expanded Ni-based metal-organic framework with enhanced double nickel cation catalysis reaction channels for a non-enzymatic sweat glucose biosensor.

Nickel-based metal-organic frameworks (Ni-MOFs) have attracted increasing attention in non-enzymatic glucose sensing. However, the insufficient active Ni cation sites from a stacked MOF layer, the unclear Ni catalysis mechanism, and the severe liquid alkaline electrolyte remain challenging for practical applications. In this work, the sonication-induced longitudinal-expansion of Ni-MOFs increases the active nickel ion sites, which not only enhances the current response to glucose detection, but also shows the oxidation peak evolution of nickel ions with different sonication times, revealing the mechanism of different glucose detection channels.

Caffeine citrate maintenance doses effect on extubation and apnea postventilation in preterm infants.

Background: Caffeine citrate is used to prevent apnea in premature infants and help in extubation of invasive ventilation, but the optimal dose remains undetermined.

Methods: Neonates born at less than 30 weeks gestation who had received invasive ventilation for at least 48 hours and a loading dose of 20 mg/kg caffeine citrate were randomly assigned into high (10 mg/kg daily) or low (5 mg/kg daily) maintenance dose groups. The drug was discontinued if no apnea occurred for 7 consecutive days.

The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein.

Background: The Ecotropic viral integration site 5 (Evi5) is recognized as a potential oncogene and a cell cycle regulator. Evi5 regulates the abundance of Emi1, an inhibitor of the anaphase-promoting complex/cyclosome, to govern mitotic fidelity. Evi5 has been shown to be dysregulated in several cancer types.

[Application of nasal endoscopy in styloid process truncating operation].

Objective: To investigate the application and the clinical effect of nasal endoscope in styloid process truncating operation.

Method: Dividing 66 patients into nasal endoscope group and control group randomly, and then observe them. Nasal endoscope group were cured with nasal endoscope during the styloid process truncating operation and the control group were treated with the routine method of intraoral path.

A multicenter study of the clinical features of allergic rhinitis in central China.

Background: Several epidemiological surveys of allergic rhinitis (AR) have been conducted in China. However, the clinical features of AR are still not clear enough. The aim of the current study was to perform a multicenter investigation to evaluate the clinical features of AR in China.

[A case report of isolated marginal zone B cell lymphoma originating from the parapharyngeal space].

This is a case report of isolated marginal zone B cell lymphoma originating from the parapharyngeal space and reaching up to the side of skull base. There are no obvious clinical symptoms of the marginal zone B cell lymphoma originating in the parapharyngeal space, the imaging examination of which showed slightly blurred edge mass shadow with heterogeneous textures and no specificity. The pathological examination revealed a large number of lymphocyte proliferation, which was not specific yet.

The efficacy of traditional Chinese Medicine as an adjunctive therapy in nasopharyngeal carcinoma: a systematic review and meta-analysis.

Purpose: The purpose of this systematic review was to assess the efficacy of traditional Chinese Medicine (TCM) as an adjunctive therapy to radiotherapy (RT) and/or chemotherapy (CT) for patients with nasopharyngeal carcinoma (NPC).

Methods: Randomized controlled trials (RCTs) with TCM to treat NPC were extensively searched in eight databases. Two researchers independently assessed the quality and validity of the included trials and extracted outcome data.

Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth and through inhibition of the PI3K/Akt pathway.

Indole-3-carbinol (I3C) is an active component of cruciferous vegetables and has been shown to markedly inhibit the growth of a variety of tumors. However, the role of I3C in nasopharyngeal carcinoma (NPC) remains unclear. Thus, the aim of the present study was to investigate the inhibition of NPC cells by I3C and .