Publications by authors named "Liisi Raam"

Psoriasis is a common, life-long skin disease with a significant negative health and societal impact. Data on rates of disease control and treatment strategies are lacking in Central and Eastern European countries. We aimed to describe the real-world disease severity, control, and treatment strategies for psoriasis in patients from Central and Eastern European countries.

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Article Synopsis
  • A study was conducted to investigate similarities and differences in protein expressions between psoriasis (PS) and atopic dermatitis (AD), using high-throughput mass spectrometry on skin samples from affected patients and healthy controls.
  • The analysis revealed a significant overlap in proteomic profiles of PS and AD, indicating they share common pathogenesis mechanisms, while both differed from healthy skin.
  • Notably, periostin (POSTN) was found to be highly expressed in AD but very low or absent in PS, suggesting its potential as a biomarker to distinguish between the two conditions.
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The role of NLRP1 inflammasome activation and subsequent production of IL-1 family cytokines in the development of atopic dermatitis (AD) is not clearly understood. Staphylococcus aureus is known to be associated with increased mRNA levels of IL1 family cytokines in the skin and more severe AD. In this study, the altered expression of IL-1 family cytokines and inflammasome-related genes was confirmed, and a positive relationship between mRNA levels of inflammasome sensor NLRP1 and IL1B or IL18 was determined.

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Article Synopsis
  • Lichen planus is a chronic skin disease that may have similarities to conditions like psoriasis, and researchers aimed to better understand its underlying metabolic factors by comparing the blood of affected patients to that of healthy individuals.
  • The study utilized high-throughput nuclear magnetic resonance (NMR) spectroscopy to analyze blood serum metabolites and lipoproteins.
  • Significant changes were found in 16 markers related to lipoproteins, which could increase the risk of comorbidities like dyslipidemia and associated cardiovascular issues due to disturbed lipoprotein particle processing.
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The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus here was on twelve genes related to the signal transduction between them. Additionally, five endogenous opioid system genes that are involved in cutaneous inflammation were examined.

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Psoriasis is a chronic inflammatory skin disease with numerous involved factors. miR-146a and miR-146b (miR-146a/b) are anti-inflammatory miRNAs that are increased in psoriatic skin. SERPINB2 has been shown to be upregulated in the inflammation and infections.

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Background: miR-10a-5p has been shown to regulate cancer cell proliferation and invasiveness and endothelial cell inflammatory responses. The function of miR-10a-5p in the skin has not been previously studied. The aim of the current study was to examine miR-10a-5p expression, regulation, and function in keratinocytes (KCs) in association with atopic dermatitis (AD).

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Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss of self-tolerance toward melanocytic antigens are not understood. This research aimed to identify novel cellular and molecular factors that participate in vitiligo pathogenesis through the application of gene expression and immunofluorescence analysis of skin biopsy samples along with immunophenotyping of circulating cells.

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