High serum creatinine concentration is associated with metabolic perturbations in dogs.

Background: The kidneys have many essential metabolic functions, and metabolic disturbances during decreased renal function have not been studied extensively.

Objectives: To identify metabolic changes in blood samples with increased serum creatinine concentration, indicating decreased glomerular filtration.

Animals: Clinical samples analyzed using a nuclear magnetic resonance (NMR) based metabolomics platform.