Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.
View Article and Find Full Text PDFThe tobacco seedling stage is a crucial period for tobacco cultivation. Accurately extracting tobacco seedlings from satellite images can effectively assist farmers in replanting, precise fertilization, and subsequent yield estimation. However, in complex Karst mountainous areas, it is extremely challenging to accurately segment tobacco plants due to a variety of factors, such as the topography, the planting environment, and difficulties in obtaining high-resolution image data.
View Article and Find Full Text PDFObjective: Observational studies have reported that mental disorders are comorbid with temporomandibular joint disorder (TMD). However, the causal relationship remains uncertain. To clarify the causal relationship between three common mental illnesses and TMD, we conduct this Mendelian Randomization (MR) study.
View Article and Find Full Text PDFObjective: To explore the effect of glutathione on serum oxidative stress, inflammatory reaction, and brain injury in patients with Sevoflurane inhalation general anesthesia based on iron metabolism pathway.
Methods: From January 2018 to January 2023, 120 patients undergoing Sevoflurane inhalation anesthesia in Xingtai Third Hospital were divided into a control group and an observation group. The control group was given routine treatment, and the observation group patients were given oral glutathione tablets 2 weeks before anesthesia based on the control group.
Sulfuric acid is involved in carbonate rock dissolution in karst areas and affects regional hydrogeochemical and carbon cycling processes. Sulfate sources and carbonate weathering at dripwater points of different hydrological types also differ significantly. Therefore, in this paper, three dripwater points (SQ2#, PB and MH6#) of different hydrological types in Dafeng Cave and Mahuang Cave were selected and systematically analyzed.
View Article and Find Full Text PDFWireless power transfer (WPT) is a technology that enables energy transmission without physical contact, utilizing magnetic and electric fields as soft media. While WPT has numerous applications, the increasing power transfer distance often results in a decrease in transmission efficiency, as well as the urgent need for addressing safety concerns. Metamaterials offer a promising way for improving efficiency and reducing the flux density in WPT systems.
View Article and Find Full Text PDFStalagmites are considered natural archives of climate proxies. However, under the combined effects of atmospheric circulation patterns, precipitation, and karst environments, drip hydrogeochemical processes can be coupled and linked to each other to control cave sediment record information. Therefore, the evolution of chemistry and factors controlling the isotopic composition of the dripwater during regional precipitation migration from the surface to caves need to be evaluated.
View Article and Find Full Text PDFObjective: The current review aimed to assess the efficacy of adjunctive chlorhexidine (CHX) in the non-surgical treatment of peri-implantitis/peri-implant mucositis.
Methods: PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched up to 10 March 2022 for relevant randomized controlled trials or controlled clinical trials.
Results: Fourteen studies were included.
Alzheimer's disease (AD) is a progressive neuro-degenerative disease characterized by dementia. MicroRNAs (miRNAs) are involved in many diseases, including AD. MiR-132-3p has been identified to be downregulated in AD.
View Article and Find Full Text PDFEvid Based Complement Alternat Med
September 2021
Objective: To establish the diagnosis model for syndromes of type 2 diabetes mellitus (T2-DM) and explore symptoms, the pulse and tongue signs, and laboratory indexes related to syndromes of T2-DM.
Methods: A syndromatologic and laboratory investigation was conducted in 554 T2-DM patients with 58 symptoms, 14 tongue signs, 6 pulse signs, and 12 laboratory indexes. The clinical data on the syndrome were collected and analyzed by using logistic regression analysis, decision tree, and -nearest neighbor to establish a diagnostic model for effectively distinguishing the typical syndromes in T2-DM patients.
Background: The aim of this study is to evaluate the implant survival/success rate, gain in alveolar bone height, crestal bone loss, and complications associated with implants placed in the posterior maxilla after osteotome sinus floor elevation without bone substitutes.
Methods: The electronic databases, such as MEDLINE, EMBASE, CENTRAL, and SCOPUS were systematically and manually searched for publications in peer-reviewed journals. The included articles were subjected to qualitative and quantitative analyses, and the meta-analysis was carried out for single-arm studies.
The loosening and displacement of prostheses after dental implantation and arthroplasty is a substantial medical burden due to the complex correction surgery. Three‑dimensional (3D)‑printed porous titanium (pTi) alloy scaffolds are characterized by low stiffness, are beneficial to bone ingrowth, and may be used in orthopedic applications. However, for the bio‑inert nature between host bone and implants, titanium alloy remains poorly compatible with osseointegration, especially in disease conditions, such as osteoporosis.
View Article and Find Full Text PDFBackground: Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. However, no systematic review specifically investigated this topic.
View Article and Find Full Text PDFObjective: To evaluate the effects of home-based exercise and physical activity on cardiac functional performance in patients after acute myocardial infarction (MI) during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: This retrospective study enrolled patients that received treatment of acute ST-segment elevation MI between and were followed-up 6 months later. The patients were divided into physically active and inactive groups based on their levels of home exercise after hospital discharge.
Clinicians treating overdenture patients need to know if immediate loading and conventional loading results in similar outcomes. This study aimed to perform a systematic literature search of studies comparing immediate and conventional loading of mandibular overdentures irrespective of the number of implants and conduct a meta-analysis of implant failure and marginal bone loss (MBL). A literature search of PubMed, ScienceDirect, Ovoid, Springer, and Google Scholar databases was performed for randomized controlled trials (RCTs) comparing immediate vs conventional loading of mandibular overdentures.
View Article and Find Full Text PDFPlacing implants in the edentulous jaw of an individual with severe posterior mandibular atrophy is challenging due to the insufficient bone height above the inferior alveolar nerve canal. The different reconstruction techniques available cause extensive morbidity, are costly, and require prolonged treatments. In here we report a case series of patients treated with a new minimally invasive technique to facilitate implant placement in patients with severely atrophied posterior mandible.
View Article and Find Full Text PDFCompound Danshen dripping pills (CDDP) is widely used for the treatment of coronary arteriosclerosis and ischemic heart diseases for decades of years. In our study, we interestingly discovered the effects and mechanism of CDDP on insulin resistance that increase the risk factor of cardiovascular diseases. Effects of CDDP on fasting blood glucose, the insulin tolerance test (ITT), the oral glucose tolerance test (OGTT), hepatic function, and underlying mechanism were analyzed in ob/ob mice.
View Article and Find Full Text PDFAims: Previous studies suggest that small intestinal bacterial overgrowth (SIBO) is associated with type 2 diabetes. However, few studies have evaluated the association between SIBO and beta-cell function in type 2 diabetes. The aim of this study was to evaluate whether beta-cell function was associated with SIBO.
View Article and Find Full Text PDFBiochem Biophys Res Commun
June 2020
Impaired insulin sensitivity of insulin-sensitive tissues plays a major role in the pathogenesis of type 2 diabetes, salvianolic acid B (SalB), a natural antioxidant usually treated various cardiovascular diseases was also reported potential utility on diabetes and dyslipidemia. Based on these, we aimed to explored whether the antioxidant effect of SalB play a pivotal role in the molecular mechanisms leading to insulin resistance. We found that SalB improved glucose tolerance and insulin sensitivity, decreased serum ALT, AST and ALP levels of ob/ob mice.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is the fourth most prevalent malignant tumor and the second leading cause of cancer-related death around the world. Aberrant proliferation and metastasis are the mainspring of death in patients with GC. However, the specific mechanism of gastric cancer is far from being fully elucidated.
View Article and Find Full Text PDFAnn Thorac Surg
January 2019
Background: MicroRNA(miR)-204 is an autophagy- and apoptosis-related gene. Neuroprotection by the inhibition of miR-204 against spinal cord ischemia was evaluated, and the roles of neuronal autophagy and apoptosis were investigated.
Methods: Spinal cord ischemia was conducted in rats by cross-clamping the descending aorta for 14 minutes.
Phys Chem Chem Phys
August 2017
We optimized the high pressure-temperature phase diagram of pure Co up to the liquidus temperature and 120 GPa, based on thermodynamic properties calculated using first-principles. The Gibbs energy for each phase was evaluated in the framework of a quasiharmonic approximation, with a consideration of the thermal electronic contribution at finite temperatures. Particularly, the liquidus temperature, as a function of pressure, was determined using classical Molecular Dynamics simulations.
View Article and Find Full Text PDFObjective: Mitophagy results in selective clearance of damaged mitochondria. We investigated whether mitophagy was involved in the neuroprotection by inhibiting microRNA (miRNA)-124 on ischemic spinal cords.
Methods: Inhibition of miRNA-124 was conducted by intrathecal injection of lentivirus vectors containing antagomiR-124.