2D Nano-Photosensitizer Facilitates Proximity Labeling for Living Cells Surfaceome Deciphering.

Photocatalytic proximity labeling has shown great promise for mapping the spatiotemporal dynamics of surfaceome. Although cell-surface targeting photosensitizers relying on antibodies, lipid molecules, and metabolic labeling have gained effects, the development of simpler and stable methods that avoid complex chemical synthesis and biosynthesis steps is still a huge challenge. Here, the study has introduced 2D nanomaterials with the ability of cell surface engineering to perform the in situ anchoring of photosensitizer on living cell surface.

The Influence of Group Favoritism on Moral Judgment -- Evidence From Event-Related Potential.

When judging the morality of an action, individuals may exhibit a bias stemming from group favoritism. It leads to the expression of different moral evaluations of the same behaviors performed by different social groups. The current study used event-related potentials (ERPs) to investigate the influence of in-group favoritism (in-group vs.

Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T.

CD19-targeted chimeric antigen receptor T lymphocytes (CAR-T) has demonstrated a high proportion of complete remission in the treatment of relapsed refractory acute B cell lymphoblastic leukemia (r/r B-ALL). It is of great clinical significance to explore which factors will impact long-term disease-free survival of patients with r/r B-ALL after CAR-T therapy without bridging bone marrow transplantation. Our study found that, in patients with r/r B-ALL without bridging transplantation, the patients' age; infusion dosage; whether they had undergone allo-stem cell transplantation before CAR-T therapy, using CD-19-targeted or CD19/CD22-dual-targeted CAR-T; whether there is fusion gene; tumor burden before therapy; and comorbidity had no significant relationship with their long-term disease-free survival.

Widespread protein N-phosphorylation in organism revealed by SiO@DpaZn beads based mild-acidic enrichment method.

Protein phosphorylation is one of the most commonly studied and ubiquitous post-translational modifications (PTMs), and defining site-specific phosphorylation is essential to understand basic and disease biology. However, the chemical properties and biological activities hamper the detection of non-canonical N-phosphorylation from biological samples, and the study of N-phosphorylation over the last half century has lagged behind canonical O-phosphorylation. Here, a mild-acidic method based-on SiO@DpaZn beads was developed for protein N-phosphorylation sites identification.

Evaluation of correlation between sagittal balance and plantar pressure distributions in adolescent idiopathic scoliosis: A pilot study.

Background: To evaluate the correlation between baropodometric parameters and sagittal parameters for adolescent idiopathic scoliosis.

Methods: 44 volunteers (7 males and 37 females) were recruited. All participants were diagnosed as adolescent idiopathic scoliosis by X-ray before baropodometric study.

Establishment of mink heart identification method based on mitochondrial cytochrome b gene and development of its detection kit.

In this study, the mink heart mitochondrial DNA was used as the target gene to design the specific primers of mink heart mtDNA Cytb, the extraction and detection reagents of mink heart DNA were developed using DNA fingerprinting technique, and the specificity, reproducibility, and stability of the reagents were investigated. Molecular cloning and sequencing technique were used to clone the standard substance of mink heart DNA detection, then a DNA fingerprint detection method of mink heart and the quality standard for mink heart were established, and a DNA detection kit of mink heart was developed. The results showed that the structure of DNA extracted from mink heart by self-developed reagents was complete, and both the concentration and purity of DNA were high.

Self-Compassion and Confucian Coping as a Predictor of Depression and Anxiety in Impoverished Chinese Undergraduates.

The ability of self-compassion and Confucian coping to predict anxiety and depression were examined in impoverished Chinese undergraduate students. Three hundred and thirty impoverished undergraduates completed measures of self-compassion, Confucian coping, depression, and anxiety. Results showed that higher self-compassion predicted lower depression and anxiety in impoverished undergraduates.

Clinical characterization and risk factors of Clostridium difficile infection in elderly patients in a Chinese hospital.

Introduction: Clostridium difficile is a common cause of nosocomial diarrhea, especially in elderly patients. This study aimed to analyze the clinical features and assess the risk factors associated with Clostridium difficile infection (CDI) in elderly hospitalized patients.

Methodology: A retrospective case-control study was conducted among elderly hospitalized patients (> 60 years of age) in a Chinese tertiary hospital between 2010 and 2013.

Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT.

Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. Apigenin is a flavonoid that possesses various clinically relevant properties such as anti-tumour, anti-platelet and anti-inflammatory activities. Our results showed that apigenin has anti-proliferation, anti-invasion and anti-migration effects in three kinds of colorectal adenocarcinoma cell lines, namely SW480, DLD-1 and LS174T.

Application of an improved biuret method to the determination of total protein in urine and cerebrospinal fluid without concentration step by use of Hitachi 7170 auto-analyzer.

A biuret automated colorimetric assay for total protein in urine and cerebrospinal fluids was established. The procedures were as follows. Acidify all urine sample before analysis.