Olaparib reverses prostate cancer resistance to Rapamycin by promoting macrophage polarization towards the M1 phenotype.

Prostate cancer (PCa) is the most common non-cutaneous malignancy and the second leading cause of cancer-related death in men. Despite its prevalence, treatment outcomes are often unsatisfactory, necessitating the search for more effective therapeutic approaches. mTOR inhibitor Rapamycin (RAPA) has shown promise in managing PCa, but the emergence of resistance often undermines its long-term effectiveness.

Sesquiterpene enantiomers from Alismatis Rhizoma.

A pair of dinor-sesquiterpene enantiomers (1a/1b), eight pairs of guaiane-type sesquiterpenes enantiomers (2a/2b, 3a/3b, 4a/4b, 5a/5b, 6a/6b, 7a/7b, 8a/8b, 9a/9b) and two guaiane-type sesquiterpenes (10, 11), including eleven undescribed ones (1a, 1b, 2a, 2b, 3a, 3b, 4a, 5b, 6a, 10, and 11), were isolated from the aqueous extract of Alismatis Rhizoma. The structures were elucidated by combining 1D and 2D NMR and HRESIMS spectroscopic data. The absolute configurations were determined by experimental and calculated ECD spectra, [Mo(OAc)]-induced ECD spectral analysis, and comparison of the experimental ECD spectra with those of similar analogs.

Cuproptosis-related signature predicts prognosis and indicates tumor immune infiltration in bladder cancer.

Background: Cuproptosis is a newly identified form of cell death that is dependent on copper (Cu) ions, termed Cu-dependent cytotoxicity. This process is distinct from other forms of cell death such as apoptosis, necrosis, and ferroptosis. The accumulation of copper is known to play a significant role in various biological processes, including angiogenesis (the formation of new blood vessels) and metastasis (the spread of cancer cells to different parts of the body).

A Mixed-Methods Study to Evaluate Depression and Anxiety Among Undergraduate Nursing Students.

Introduction: As the backbone of future healthcare delivery, the mental health of undergraduate nursing students can have a direct impact on patients' perceptions of health and the quality of their healthcare learning. However, there has been little qualitative research on the factors influencing the mental health of undergraduate nursing students.

Aim: This study investigated the current status and factors influencing depression and anxiety in undergraduate nursing students.

[A new neolignan glycoside from Acori Tatarinowii Rhizoma].

The main chemical constituents from Acori Tatarinowii Rhizoma were isolated and purified using the macroporous resin,microporous resin(MCI) and octadecylsilyl silica gel(ODS) column chromatography, as well as semi-preparative high performance liquid chromatography. Their chemical structures were elucidated by spectroscopic analyses including mass spectrometry(MS),nuclear magnetic resonance(NMR), ultraviolet(UV), infrared(IR) and circular dichoism(CD) combined with literature data.A total of 11 compounds were isolated and identified, including 4 lignan glycosides, 2 benzyl alcohol glycosides, 4 flavonoid glycosides, and 1 α-tetralone glycoside:(7S,8R)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranosyl-9'-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside(1),(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside(2),(7S, 8R)-dihydrodehydrodiconiferyl alcohol di-9, 9'-O-β-D-glucopyranoside(3),(+)-lyoniresinol 3α-O-β-D-glucopyranoside(4), benzyl alcohol O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(5), benzyl alcohol O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside(6), 3'-O-methylepicatechin 7-O-β-D-glucopyranoside(7), 3'-O-methylcatechin 7-O-β-D-glucopyranoside(8), apigenin 6-C-β-D-glucopyranosyl-7-O-β-D-glucopyranoside(9), isoscoparin 7-O-β-D-glucopyranoside(10), and(4R)-8-hydroxy-α-tetralone-4-O-β-D-glucopyranoside(11).

Efficacy of predictive pain intervention in patients with aortic dissection.

Background: Aortic dissection is usually managed with interventional therapy, conservative therapy, and surgery to inhibit disease progression and improve prognoses. Nevertheless, the absence of meticulous and effective nursing during the treatment greatly increases the complication rates, which is detrimental to the recovery of patients.

Objective: This study aimed to explore the efficacy of predictive pain intervention in the nursing process of patients with aortic dissection.

Four pairs of new enantiomeric guaiane sesquiterpenoids from the rhizomes of Alisma plantago-aquatica.

Four pairs of undescribed enantiomeric guaiane sesquiterpenoids, (±)-alismaenols A-D (1a/1b, 3a/3b-5a/5b), together with a pair of known ones (2a/2b) were isolated from the rhizomes of Alisma plantago-aquatica. The structures and relative configurations of the isolates were established by analysis of their 1D, 2D-NMR and HRESIMS data. Their absolute configurations were determined by comparison of their experimental CD spectra and calculated electronic circular dichroism (ECD) spectra or by single-crystal X-ray diffraction analysis.

Individualized prediction of conditional survival for colorectal signet-ring cell carcinoma patients.

Background: Conditional survival (CS) considers the time already survived after surgery and may provide additional survival information. The authors sought to construct and validate novel conditional survival nomograms for the prediction of conditional overall survival (OS) and cancer-specific survival (CSS) of colorectal signet-ring cell carcinoma (SRCC) patients.

Methods: Patients diagnosed with stage I-III SRCC between 2010 and 2019 were identified from the Surveillance, Epidemiology, and End Results database.

Aqueous extract of fermented Eucommia ulmoides leaves alleviates hyperlipidemia by maintaining gut homeostasis and modulating metabolism in high-fat diet fed rats.

Background: As a traditional Chinese medicinal herb, the lipid-lowing biological potential of Eucommia ulmoides leaves (EL) has been demonstrated. After fermentation, the EL have been made into various products with lipid-lowering effects and antioxidant activity. However, the anti-hyperlipidemic mechanism of fermented Eucommia ulmoides leaves (FEL) is unclear now.

Fingerprint analysis of dang-gui-Si-Ni decoction and its anticoagulant activity in vivo-in vitro.

Ethnopharmacological Relevance: Dang-Gui-Si-Ni (DGSN) decoction is a classic prescription in the clinical practice of traditional Chinese Medicine (TCM). DGSN decoction is often used to relieve symptoms of cold coagulation and blood stasis recorded by Treatise on Febrile Diseases (Shang Han Lun) and treat Raynaud's disease, dysmenorrhea, arthritis, migraine in TCM clinic. Accumulated evidences have suggested that this diseases are related to microcirculation disturbance.

[Research progress on natural guaiane-type sesquiterpenoids and their biological activities].

Guaiane-type sesquiterpenoids are a class of terpenoids with [5,7] ring-fused system as the basic skeletal structure composed of three isoprene units, which are substituted by 4,10-dimethyl-7-isopropyl. According to the difference in functional groups and degree of polymerization, they can be divided into simple guaiane-type sesquiterpenoids, sesquiterpene lactones, sesquiterpene dimers, and sesquiterpene trimers. Natural guaiane-type sesquiterpenoids are widely distributed in plants, fungi, and marine organisms, especially in families such as Compositae, Zingiberaceae, Thymelaeaceae, Lamiaceae, and Alismataceae.

Psychological Stress and Coping Strategy Profiles Among Frontline Medical Workers During the COVID-19 Pandemic.

This study aimed to explore coping strategy profiles used by frontline medical workers and the psychological stress reactions associated with each category, in the COVID-19 pandemic context. Participants were 651 frontline medical workers recruited between February and March 2020. Psychological stress reactions (e.

Investigation into the electrochemical advanced oxidation of p-arsanilic acid: Peculiar role of electrolytes and unexpected formation of coupling byproducts.

Although banned in some countries, p-arsanilic acid (ASA) is still widely used as feed additive in poultry production. As a result, ASA is usually released into the aquatic environment without any treatments. Although ASA exhibits low toxicity, it can be transformed into highly toxic aromatic amines and inorganic arsenic species (As (V) as HAsO and HAsO) under natural environmental conditions.

Synergistic Effects between Lignin, Cellulose and Coal in the Co-Pyrolysis Process of Coal and Cotton Stalk.

In this work, Qiqunahu (QQH) coal, cotton stalk, cellulose and lignin extracted from cotton stalk were selected as raw materials to study the effects of the co-pyrolysis of coal and cotton stalk. Online thermogravimetric mass spectrometry (TG-MS) was used to analyse mass loss and gas release characteristics during co-pyrolysis. The results reveal that the mixture of cotton stalk and coal can significantly enhance the reactivity of the blends and promote the formation of effective gas.

[Hot water washing processing technology of Euodiae Fructus based on change laws of active components and tastes].

In order to establish the standardized processing technology of the hot water washing of Euodiae Fructus, this study, based on the traditional processing method of hot water washing of Euodiae Fructus recorded in ancient works and modern processing specifications of traditional Chinese medicine decoction pieces, took the yield of decoction pieces and the content of main components as the indicators and optimized the processing conditions by orthogonal test based on the results of single factor investigation. At the same time, electronic tongue technology was used to analyze the change law of the taste index of Euodiae Fructus during the hot water washing. The results of the single factor investigation showed that the content of the main components in Euodiae Fructus showed some regular changes during the processing.

Tuning the Zn solvation structure in dual-salts hybrid aqueous electrolyte to stabilize the Zn metal anode.

Aqueous Zn-ion battery is expected to become a substitute for Li-ion battery due to its inherent safety, low cost, and environmental friendliness. Dendrite growth and side reaction problems during electroplating lead to its low Coulombic efficiency and unsatisfactory life, which greatly limits its practical application. Here, we propose a dual-salts hybrid electrolyte, which alleviates the above issues by mixing Zn(OTf) to ZnSO solution.

Nitrogen-Doped Hierarchical Porous Carbon Derived from Coal for High-Performance Supercapacitor.

The surface properties and the hierarchical pore structure of carbon materials are important for their actual application in supercapacitors. It is important to pursue an integrated approach that is both easy and cost-effective but also challenging. Herein, coal-based hierarchical porous carbon with nitrogen doping was prepared by a simple dual template strategy using coal as the carbon precursor.

Constructing the quinonyl groups and structural defects in carbon for supercapacitor and capacitive deionization applications.

The structural defects and oxygen-containing functional groups of carbon materials as electrode materials for supercapacitors or capacitive deionization devices are critical to their electrochemical performance. The tuning of surface oxygen-containing functional groups and carbon defects during pyrolysis is key to achieve a high performance in ion storage. Herein, quinonyl-dominant defective porous carbon is prepared by a pyrolysis and cross-linking route using lavender stem and potassium acetate as precursor.

Dual-Salt-Induced Hierarchical Porous Structure in a Carbon Sheet for High Performance Supercapacitors.

Porous carbon, one of the characteristic materials for electrochemical energy storage devices, has been paid wide-ranging attention. However, balancing the reconcilable mesopore volume with a large specific surface area (SSA) was still a challenge. Herein, a dual-salt-induced activation strategy was developed to obtain a porous carbon sheet with ultrahigh SSA (3082 m g), desirable mesopore volume (0.

Correlation of GDFT combined with rehabilitation therapy in DNA damage repair of esophageal cancer cells.

Esophageal cancer is a common malignant tumor with a high incidence and a serious threat to human health. The treatment of esophageal cancer is a complex process, which requires the comprehensive use of a variety of treatment methods. At present, the treatment of esophageal cancer mainly includes surgery, radiotherapy, chemotherapy and immunotherapy.

Protective effect of compatible herbs in Jin-Gu-Lian formula against -induced neurotoxicity oxidative stress, neurotransmitter metabolisms, and pharmacokinetics.

frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with compatible herbs in Jin-Gu-Lian formula attenuates such neurotoxicity according to the compatible principle of traditional Chinese medicines.