Three-Dimensional Finite Element Analysis on En-Masse Retraction of the Maxillary Anterior Teeth With Quantitative Combined Loading Control.

This study aims to elucidate the biomechanical effects of combined loading of maxillary anterior and posterior implants using the sliding method on en-masse retraction of the anterior teeth and to quantify the loading ratio (LR) of anterior and posterior implants to achieve controlled retraction of the maxillary anterior teeth. A three-dimensional finite element model of the maxilla-upper dentition appliance was constructed. Implants were placed on the distal (A) and mesial (B) sides of the lateral incisors as well as on the mesial (C) side of the first molar and different amounts of force were loaded between the implants using 2- or 5-mm traction hooks.

Three-dimensional finite element analysis of the stability of mini-implants close to the roots of adjacent teeth upon application of bite force.

To investigate the cause of mandibular implant loss, we evaluated the stress distribution in the bone under bite force when the miniimplant was near the root using three-dimensional finite element analysis. Our analysis involved four finite element models with different distances between the implant and adjacent tooth root and three loading conditions. With loading of the tooth only or both the tooth and implant, the peak stress within the bone around the implant neck, displacement, and stress surrounding the bone near the root increased as the distance between the implant and root decreased.

Finite Element Analysis of Bone Stress for Miniscrew Implant Proximal to Root Under Occlusal Force and Implant Loading.

Because of the narrow interradicular spaces and varying oral anatomies of individual patients, there is a very high risk of root proximity during the mini implants inserting. The authors hypothesized that normal occlusal loading and implant loading affected the stability of miniscrew implants placed in proximity or contact with the adjacent root. The authors implemented finite element analysis (FEA) to examine the effectiveness of root proximity and root contact.

Dose-dependent targeted knockout methodology combined with deep structure elucidation strategies for Chinese licorice chemical profiling.

One of the limitations with regards to the chemical profiling of Chinese herbs is that low-level compounds are masked by high-level structures. Here, we established a novel methodology based on a dose-dependent targeted knockout (DDTK) technique combined with deep structure elucidation strategies to allow the chemical profiling of Chinese licorice. We employed ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q/TOF MS) incorporated with the DDTK technique to identify the compounds in different concentration samples and found that the compounds at the high- or medium-level were detected readily in the sample at a low concentration; subsequently, minor or trace-level constituents were identified in the sample at a high concentration by rejecting high-level constituents detected in the sample at a low concentration based on a heart-cutting technique during analysis.

[Mini-implant stability analysis at different healing times before loading].

Objective: This study aims to biomechanically analyze a mini-implant at different healing times before loading.

Methods: Sixty-four mini-implants with (12 +/- 1) N x cm insertion torque were placed in the low jaw of eight beagle dogs. The test mini-implants remained in the low jaw for 0, 1, 3, and 8 weeks of bone healing and for an additional 10 weeks under a force of 0.

Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions.

Ethnopharmacological Relevance: Liquorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L., Leguminosae.

Sec14l3 is specifically expressed in mouse airway ciliated cells.

Airway epithelium is a key component for airway integrity. Previously, we found that expression of the Sec14l3 gene that encodes a 45-kDa secretory protein is inversely associated with the progression of experimentally induced airway inflammation and degeneration/necrosis of alveolar epithelium. In this report, using in situ hybridization we demonstrated that the ciliated cells in mouse lung selectively express Sec14l3 mRNA.

[The effect of mini-implant lengths on stress distributions in peri-implant surface].

Objective: To observe the effect of mini-implant lengths on stress distribution in peri-implant surface.

Methods: The 3D finite element analysis mandible and mini-implant models with diameter of 1.6 mm, lengths of 6, 8, 10 and 12 mm were established.

Inverse relationship between Sec14l3 mRNA/protein expression and allergic airway inflammation.

Bronchial asthma is an inflammatory disease of the airways. The Sec14l3 gene, encoding a 45-kDa secretory protein, is specifically expressed in airway epithelium. Here, we report on the kinetics of Sec14l3 expression following allergic inflammation of the lung.

T cells are involved in the development of arthritis induced by anti-type II collagen antibody.

T cells play an important role in initiating autoimmune responses and maintaining synovial inflammation in rheumatoid arthritis. Although, anti-type II collagen antibody-induced arthritis (CAIA) is generally believed to be a T cell- and B cell-independent model, the detailed pathogenesis of CAIA remains unclear. In the present study, to elucidate the contribution of T cells to the pathogenesis of CAIA, we evaluated the effects of CTLA4 Ig and cyclosporin (CsA).

Validation of universal conditions for duplex quantitative reverse transcription polymerase chain reaction assays.

Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) is widely used for measuring mRNA in biological materials. Multiplex qRT-PCR provides advantages for gene expression analysis by reducing sample requirements, saving time, and lowering experimental cost. However, there are currently no universal qRT-PCR experimental conditions validated as applicable to a large set of genes.