Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling.

Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT).

Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD.

Background: High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed the independent, joint effects as well as their interactions of toxic metals and OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD).

Methods: Participants with NAFLD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included.

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control.

Purpose: The purpose of this study was to quantify the corneal power changes after wearing orthokeratology lenses of different back optic zone diameters (BOZDs) and to propose a novel 4-parameter model capable of revealing the associations between each parameter and axial length growth (ALG).

Methods: A prospective self-controlled study was conducted between June 2022 and December 2023. One eye in each subject (N = 33) was randomly assigned to wear a lens with a BOZD of either 5 mm (5 oz) or 6 mm (6 oz).

Study on the improvement of vegetated concrete substrate by biochar and limestone calcined clay cement.

Vegetated concrete has proven to be an effective technique for restoring the ecological environment of rocky slopes, but conventional formulations often suffer from excessive cement content and limited plant growth. This study proposes the use of biochar (BC) and limestone calcined clay cement (LC3) to form an improved vegetated concrete mix. Twenty-five different formulations were tested for their compressive and shear strength, pH values, and Bermuda grass growth.

NagPIBAF upregulation and ompO downregulation compromise oxidative stress tolerance of Stenotrophomonas maltophilia.

Background: Outer membrane protein OmpA is composed of two domains, an N-terminal β-barrel structure embedded in the outer membrane and a C-terminal globular domain noncovalently associated with the peptidoglycan layer in periplasm. Stenotrophomonas maltophilia KJ is a clinical isolate. In our recent study, we disclosed that KJ∆OmpA an OmpA C-terminal deletion mutant, compromised menadione tolerance.

Effects of biomedical macromolecules on the structure of chitin liquid crystals.

The chitin whiskers (CHWs) form liquid crystals in colloidal suspensions due to their unique anisotropic structure, showing enormous potential for applications in optical materials, biomedical materials and other fields. Chitin liquid crystal (CLC) usually requires the introduction of a macromolecular system to form thin films or hydrogels to achieve the purpose of fixing the anisotropic liquid crystal texture. This study aims to systematically explore the interaction between macromolecules and CHWs, clarify the influence of macromolecules on the behavior of CLC.

m6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapy.

M6A modification is one of the most common regulatory mechanisms of gene expression in eukaryotic cells, influencing processes such as RNA splicing, degradation, stability, and protein translation. Studies have shown that m6A methylation is closely associated with tumorigenesis and progression, and it plays a key regulatory role in tumor immune responses. m6A modification participates in regulating the differentiation and maturation of immune cells, as well as related anti-tumor immune responses.

Car-following safety modeling and risk assessment of autonomous vehicle in icy and snowy weather.

This paper is to study the effect of icy and snowy weather on the car-following (CF) safety of autonomous vehicle (AV). The influence of weather is abstracted as mathematical model parameters, and the CF model and risk decision equation of AV under icy and snowy weather are constructed. Comparing the influence of various climates on the CF of AV and the potential safety hazards, the CF parameters of AV in icy and snowy weather are designed based on Intelligent Driver Model (IDM).

Regulates Rice Cold Tolerance by MAPK Signaling Pathway and Ethylene Signaling Pathway.

Low temperature stress represents a significant abiotic stress factor affecting rice yields. While the structure and some of the functions of cell cycle protein-dependent protein kinase inhibitor (CKI) family proteins have been the subject of study, their relevance to cold tolerance in rice has been less investigated. In this study, we cloned () and constructed anti-expression lines of this gene.

Contribution of fepA, fciABC, sbaA, sbaBCDEF, and feoB to ferri-stenobactin acquisition in Stenotrophomonas maltophilia KJ.

Background: Stenotrophomonas maltophilia, an opportunistic pathogen, is ubiquitously distributed in the environment. In response to iron-depletion stress, S. maltophilia synthesizes the sole catecholate-type siderophore, stenobactin, for ferric iron acquisition.

Roles of the operon in superoxide tolerance and β-lactam susceptibility of .

Introduction: The pair is a regulatory system used by photosynthetic microorganisms to overcome singlet oxygen stress. and encode the sigma factor σ and anti-sigma factor ChrR, respectively. Stenotrophomonas maltophilia, an opportunistic pathogen, is a multidrug-resistant gram-negative bacterium.

Relationship between accelerometer-measured physical activity and depressive symptoms in hemodialysis patients with comorbid diabetes mellitus: a multicenter cross-sectional study.

Objective: The objective of this study was to examine the association between accelerometer-derived moderate-to-vigorous physical activity (MVPA) and depressive symptoms in hemodialysis patients with and without type 2 diabetes mellitus (T2DM).

Methods: This cross-sectional study finally included 450 maintenance hemodialysis patients (male 281, average age 62 years) from seven dialysis centers in Shanghai, China. Physical activity (PA) was measured using the triaxial accelerometer (ActiGraph GT3X+, Pensacola, FL, United States).

Overexpression of enhances salt tolerance in rice.

Excessive salt accumuln in soil is one of the most important abiotic stresses in agricultural environments. The Domain of Unknown Function 868 (DUF868) family, comprising 15 members in rice, has been identified in the protein family database. In this study, we cloned and functionally characterized , a member of the OsDUF868 family, to elucidate its role in rice response to salt stress.

Impact of Patient and Caregiver Beliefs on Utilization of Hospice and Palliative Care in Diverse Patients With Advanced Lung Cancer.

Objectives: To evaluate the impact of patient and caregiver hospice care (HC) and palliative care (PC) beliefs and patient/caregiver belief-agreement on subsequent utilization of HC/PC among racially and ethnically diverse patients.

Methods: A prospective cohort study of newly diagnosed patients ≥18 years old with advanced lung cancer and their caregivers was conducted. Participants completed validated surveys at multiple points and electronic health records were reviewed to evaluate utilization.

New understanding on iota-carrageenan oxidation by hydrogen peroxide with or without copper sulphate and the properties of oxidized iota-carrageenan.

To explore the oxidation mechanism of iota-carrageenan (IC) and the potential applications of oxidized IC (OIC), a series of OIC samples were firstly synthesized under hydrogen peroxide or hydrogen peroxide/copper sulphate, their purification process, chemical composition, chemical structure, molecular weight, physical property, biosafety and antibacterial activity were systematically evaluated. Our results firstly found that only the combination of ethylenediaminetetraacetic acid disodium salt (EDTA-2Na) pre-treatment and dialysis could realize successful purification of OIC due to the strong electrostatic attractions between positive copper ions and negative sulphate ions. The introduction of copper ions could effectively speed up the oxidation of OIC, enhancing the content of aldehyde and carboxyl groups, resulting in the hydrolysis of the ether bonds in IC, inhibiting the detachment of sulphate, decreasing the molecular weight, thermal stability, characteristic temperature (i.

Association between internet use and depression among the middle-aged and elderly adults with multimorbidity in China: do gender differences exist?

Objectives: Internet use and the results of mental health are related. Numbers of studies presented the association between Internet use and depression, and the middle-aged and elderly adults with multimorbidity are of concern. The study aimed to explore the relationship between Internet use and depression in middle-aged and elderly adults with multimorbidity.

Enhanced cellular viability and osteogenic activity in oxygen-self-generating and magnetically responsive alginate microgels as advanced cell carriers.

Improving the accuracy of in vitro three-dimensional (3D) cellular cultures more closely replicates the in vivo microenvironment by mimicking the complex tissue structures, enhancing cell-cell interactions, and increasing differentiation potential along with functional capabilities. Natural materials aid in cell adhesion and proliferation within the 3D matrix, providing a more realistic growth environment. Oxygen availability is also critical for cell survival in 3D cultures, as a lack of oxygen can impede proliferation, reduce functionality, and ultimately result in cell death.

Flaxseed powder supplementation in non-alcoholic fatty liver disease: a randomized controlled clinical trial.

: Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem worldwide, and dietary interventions have important potential in the prevention and treatment of NAFLD. Moreover, previous animal studies have shown that flaxseed has a good improvement effect in animal NAFLD models. : Assess whether flaxseed powder could improve the liver lipid content in patients with NAFLD.

Neurofibroma of bladder: A case report and literature review.

To improve the understanding and treatment level of urogenital nerve fibroma by sharing the clinical manifestations, imaging features, and pathological characteristics of a case of urogenital nerve fibroma.The patient was a middle-aged male with initial symptoms of painless gross hematuria, bladder irritation, and pelvic mass. Imaging examination showed a bladder mass, and transurethral bladder tumor resection was performed to reduce the tumor.

Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis.

To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People's Hospital (January 2021-September 2023). Univariate and multivariate logistic regression analyses assessed the associations between biomarkers and severe acute pancreatitis (SAP).

Resveratrol Reduces Cisplatin-induced Cochlear Hair Cell Pyroptosis by Inhibiting the mtROS/TXNIP/NLRP3 Pathway.

Background: Cisplatin is an effective anti-cancer drug with limited clinical applications due to ototoxicity. Resveratrol, known for its antioxidant and anti-inflammatory properties, has been reported to mitigate these adverse effects, although the underlying mechanism remains under-researched.

Objective: This study aimed to investigate the effects and underlying mechanisms of resveratrol on cisplatin-induced ototoxicity.

Gallic acid-grafted chitosan photothermal hydrogels functionalized with mineralized copper-sericin nanoparticles for MRSA-infected wound management.

The management of wounds infected with drug-resistant bacteria represents a significant challenge to public health globally. Nanotechnology-functionalized photothermal hydrogel with good thermal stability, biocompatibility and tissue adhesion exhibits great potential in treating these infected wounds. Herein, a novel photothermal hydrogel (mCS-Cu-Ser) was prepared through in situ mineralization in the hydrogel networks and ion cross-linking driven by copper ions (∼3 mM).

Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tolerance.

Background: Low temperatures disrupt nitrogen metabolism in tobacco, resulting in lower nicotine content in the leaves. 24-epibrassinolide (EBR) is a widely used plant growth regulator known for its roles in enhancing cold tolerance and nitrogen metabolism. Nevertheless, it remains unclear whether EBR enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco.

Drivers of Palliative Care and Hospice Use Among Patients With Advanced Lung Cancer.

Purpose: Despite rigorous evidence of improved quality of life and longer survival, disparities in the utilization of palliative and hospice care persist for racial and ethnic minority patients with cancer. This study evaluated the impact of psychosocial factors on utilization of these services.

Methods: Patients with advanced lung cancer were recruited at a large academic urban hospital.

Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor.

Methamphetamine (METH), a synthetic stimulant, has seen an escalating abuse situation globally over the past decade. Although the molecular mechanism underlying METH-induced neurotoxicity has been explored, the dysfunction of brain-derived neurotrophic factor (BDNF) neuroprotection in the context of METH neurotoxicity remains insufficiently understood. Our previous studies have found that METH induced neurotoxicity and BDNF expression in rat primary neurons, necessitating further research into this paradox.