Antibiotic-resistant genes derived from commercial organic fertilizers are transported to balconies of residential buildings by express delivery.

The rise in antibiotic-resistant genes (ARGs) has recently become a pressing issue, with livestock manure identified as a significant source of these genes. Yet, the distribution of fertilizers derived from livestock manure sold online, potentially containing high levels of ARGs and antibiotic-resistant bacteria (ARB), is often not considered. Our study involved a random survey of commercial organic fertilizers available on online marketplaces, focusing on 13 common ARGs and 2 integrons (intI1, intI2).

Combined effect of time in target range and variability of systolic blood pressure on cardiovascular outcomes and mortality in patients with hypertension: A prospective cohort study.

Time in target range (TTR) and blood pressure variability (BPV) of systolic blood pressure (SBP) are independent risk factors for major adverse cardiovascular events (MACE) and all-cause mortality in hypertensive patients. However, the association of the combination of low TTR and high BPV of SBP with the risk of MACE and all-cause mortality is unclear. This study sought to investigate the combined effect of the TTR and BPV on the risk of MACE and all-cause mortality in patients with hypertension.

Tracing the transfer characteristics of antibiotic resistance genes from swine manure to biogas residue and then to soil.

Based on laboratory simulation experiments and metagenomic analysis, this study tracked the transmission of antibiotic resistance genes (ARGs) from swine manure (SM) to biogas residue and then to soil (biogas residue as organic fertilizer (OF) application). ARGs were abundant in SM and they were assigned to 11 categories of antibiotics. Among the 383 ARG subtypes in SM, 43 % ARG subtypes were absent after anaerobic digestion (AD), which avoided the transfer of these ARGs from SM to soil.

Investigation of reduction in risk from antibiotic resistance genes in laboratory wastewater by using O , ultrasound, and autoclaving.

Biological laboratory wastewater containing both antibiotic-resistant bacteria (ARB) and antibiotics is a potential source of antibiotic resistance genes (ARGs). Thus, we determined the efficacy of autoclaving, a common disinfection method, in eliminating 5 ARGs (sul1, sul2, tetW, tetM, amp) and the integrase-encoding gene intI1 from laboratory wastewater. Autoclaving (15 min, 121°C) inactivated all bacteria including ARB, whereas ARGs persisted in the wastewater with limited reduction even after 60 min of treatment.

Effects of carbon sources on 17 beta-estradiol degradation by Sphingomonas sp. and the analysis of the involved intracellular metabolomics.

17β-estradiol (E2) ubiquitously exists in various water bodies with long-term endocrine-disrupting and carcinogenic impacts on wildlife even at the trace level of ng L. However, it remains unclear how easy-to-degrade carbon sources alter E2 biodegradation patterns. In this study, E2 biodegradation by Sphingomonas sp.

Interaction between 17β-estradiol degradation and nitrification in mariculture wastewater by Nitrosomonas europaea and MBBR.

This study investigated the relation between 17β-estradiol (E2) degradation and nitrification in synthetic mariculture wastewater by ammonia oxidizing bacterium Nitrosomonas europaea and moving bed biofilm reactor (MBBR). Batch experiments showed that E2 degradation by N. europaea in wastewater followed zero-order reaction kinetics (r = 0.

Fast start-up strategies of MBBR for mariculture wastewater treatment.

Moving bed biofilm reactor (MBBR) is widely used for ammonia removal in saline recirculating aquaculture systems but often faces a slow start-up problem. The aim of this study was to develop a strategy for the rapid start-up of MBBR treating synthetic mariculture wastewater. Changes in nitrification performance, biofilm characteristics and bacterial community were assessed in response to various start-up strategies: R1 as the control; R2 with step-decrease of inlet NH-N; R3 with step-increase of inlet salinity; R4 added with particulate organic matter (POM) and R5 inoculated with nitrifying bacteria.

Bruceine D induces apoptosis in human non-small cell lung cancer cells through regulating JNK pathway.

Bruceine D (BD) is the quassinoids isolated from the traditional Chinese herbal medicine Brucea javanica's fruit, which exhibits anti-cancer activity. Here, we demonstrated that BD inhibited human non-small cell lung cancer (NSCLC) cell lines in vitro that were attributed to the induction of cell apoptosis. Human NSCLC H460 and A549 cell lines were treated with BD, and cell viability was conducted with CCK-8 assay.

Start-up evaluations and biocarriers transfer from a trickling filter to a moving bed bioreactor for synthetic mariculture wastewater treatment.

Mariculture wastewater treatment by nitrification requires a long start-up time due to high salinity stress. This study aimed to verify the faster start-up of a trickling filter (TF) compared to a moving bed bioreactor (MBBR) treating synthetic mariculture wastewater, and to investigate the feasibility of transferring mature biocarriers from the TF to a new MBBR (TF-MBBR). The nitrogen removal performance, biofilm physicochemical properties and microbial communities were investigated.

High removal efficiency of antibiotic resistance genes in swine wastewater via nanofiltration and reverse osmosis processes.

Swine wastewater treatment plant has become one of the main sources of antibiotic resistance genes (ARGs). Membrane treatment processes are promising solutions for removal of the emerging contaminants. However, limited studies have investigated the effects of nanofiltration and reverse osmosis treatment in removing ARGs in swine wastewater.