Ergonomic interventions to improve musculoskeletal disorders among vehicle assembly workers: a one-year longitudinal study.

Background: Musculoskeletal disorders (MSDs) constitute a significant challenge in the realm of occupational health, especially in the manufacturing sector, necessitating the development of efficacious intervention strategies to enhance musculoskeletal health and reduce the incidence of MSDs. The present study is designed to assess the efficacy of a comprehensive ergonomic intervention, specifically tailored to diminish ergonomic risk factors and the prevalence of MSDs among workers engaged in vehicle assembly line operations.

Method: This interventional study, conducted over a one-year period, was implemented among assembly line workers within a rail bound vehicle manufacturing shop.

Multiplex PCR-Mass Spectrometry Mini-Sequencing Technology Detected Antibiotic Resistance of to Six Antibiotics.

The abuse of antibiotics has led to widespread resistance to () in the population. There is an urgent need to establish a method to detect multiple antibiotic resistance rapidly. This study aimed to construct a novel strategy for the high-throughput detection of 's resistance to varying antibiotics using multiplex PCR-mass spectrometry mini-sequencing (mPCR-MS mini-sequencing) technology.

Blood trace elements in association with esophageal squamous cell carcinoma risk, aggressiveness and prognosis in a high incidence region of China.

Toxic elements exposure and imbalance in essential element homeostasis remain incomprehensive in esophageal squamous cell carcinoma (ESCC) carcinogenesis, especially in tumor progression. To reveal the toxic and essential elements inside body associated with ESCC occurrence, aggressive features and outcomes, whole blood concentrations of eight trace elements were quantified in 150 ESCC cases and 177 controls using inductively coupled plasma-mass spectrometry (ICP-MS). Concentrations of cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu), arsenic (As), and selenium (Se) showed significant differences between the case and control subjects.

Negative hemodynamic response in the visual cortex: Evidence supporting neuronal origin via hemodynamic observation and two-photon imaging.

The positive hemodynamic response (PHR) during stimulation often co-occurs with a strong, sustained negative hemodynamic response (NHR). However, the characteristics and neurophysiological mechanisms of the NHR, especially in regions distal to the PHR, remain incompletely understood. Using intrinsic optical imaging (OI) and two-photon imaging, we observed that forelimb electrical stimulation evoked strong PHR signals in the forelimb region of the primary somatosensory cortex (S1FL).

Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect gastric epithelial cell interactions.

Background: () persistently colonizes the human gastric mucosa in more than 50% of the global population, leading to various gastroduodenal diseases ranging from chronic gastritis to gastric carcinoma. Cytotoxin-associated gene A (CagA) protein, an important oncoprotein, has highly polymorphic Glu-Pro-Ile-Tyr-Ala segments at the carboxyl terminus, which play crucial roles in pathogenesis. Our previous study revealed a significant association between amino acid deletions at positions 893 and 894 and gastric cancer.

DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer.

Background: Although the prognosis of triple-negative breast cancer (TNBC) has significantly improved in the era of immunotherapy, many TNBC patients are resistant to therapies, and their disease progresses rapidly. Deciphering the metabolic mechanisms regulating anticancer immunity will provide new insights into therapeutic strategies for TNBC.

Methods: In this study, we performed bioinformatics analysis in our multi-omics TNBC database and identified that a metabolic enzyme, dihydrodiol dehydrogenase (DHDH), might promote the phenotype of "cold tumor" in TNBC.

Rapid Antimicrobial Susceptibility Test of Helicobacter pylori to Metronidazole via Single-Cell Raman Spectrometry.

Background: Metronidazole is a first-line antibiotic to treat Helicobacter pylori infections. However, the Clinical Laboratory Standards Institute guidelines recommend against using antimicrobial susceptibility test (AST) to test metronidazole resistance, due to the unreliable predictive power which can result in treatment failure.

Objectives: The aim of this study was to establish an 8-h, metabolic-phenotype based AST for H.

Enhanced compression performance of an improved rectangular helical spring incorporated support feature.

The spring system functions as a pivotal element of the check valve, with its compression performance significantly influencing the valve's time, flow stability, and other characteristics. Taking cues from conventional springs, a refined rectangular helical spring with integrated support features was thoroughly evaluated for its compression performance. The design approach for this spring was elucidated, encompassing the utilization of the Finite Element Method (FEM) to model its compression behavior.

Determination of cesium using nickel hexacyanoferrate by stripping voltammetry.

The determination of cesium ions (Cs) is important for various applications, including resource utilization, environmental monitoring, and human health. Electrochemical sensors, with their inherent advantages, stand out as an ideal choice for Cs detection. However, electrode materials for Cs sensors usually face problems such as poor selectivity and complex synthesis.

Direct Solution Deposition of Large-Area Non-Solvated Fullerene Single-Crystal Films for High-Performance n-Type Field-Effect Transistors.

Fullerene (C) crystals have attracted considerable attention in the field of optoelectronic devices owing to their excellent performance as n-type semiconductor material. However, a challenge still remains unbeaten as to the continuous crystallization of non-solvated C single-crystal films with high coverage and uniform alignment using low-cost solution techniques. Here, a facile bar coating method is used to prepare ribbon-shaped non-solvated C crystals with a large area (up to centimeters) and high coverage (>95%) by precisely controlling the crystallization process from specific solvents.

Construction and Validation of Chicken Immune scFv Antibody Library against .

Accurate diagnostic techniques and effective therapeutic methods are required to treat . The application of chicken single-chain variable fragment (scFv) antibodies may diagnose and treat . This study used the phage display technique to construct a chicken-derived immune scFv antibody library against .

Maximizing resource recovery: A green and economic strategy for lithium extraction from spent ternary batteries.

Spent ternary lithium-ion batteries contain abundant lithium resource, and their proper disposal is conducive to environmental protection and the comprehensive utilization of resources. Separating valuable metals in the ternary leaching solution is the key to ensuring resource recovery. However, the traditional post-lithium extraction strategies, which heavily rely on ion exchange to remove transition metal ions in the leachate, encounter challenges in achieving satisfactory lithium yields and purities.

The impact of pre-compression and temperature on perfluoroalkoxy alkane springs: Insights into spring relaxation.

A predictive model was proposed for determining the high-temperature free height of perfluoroalkoxy alkane springs in air-operated double-bellow pumps with the aim of investigating their relaxation. The model incorporates classical spring deformation theory and considers the material, structure, and real-world operating conditions of the perfluoroalkoxy alkane springs. Experimental validation of the model is also conducted.

A Novel Detection Procedure for Mutations in the 23S rRNA Gene of Macrolide-Resistant with Two Non-Overlapping Probes Amplification Assay.

is a significant cause of community-acquired pneumonia, which is often empirically treated with macrolides (MLs), but, presently, resistance to MLs has been a matter of close clinical concern. This assay is intended to contribute to resistance detection of in clinical practice. A novel real-time PCR assay with two non-overlapping probes on the same nucleic acid strand was designed in this study.

A Novel Mitochondrial Targeted Compound Phosundoxin Showing Potent Antifungal Activity against Common Clinical Pathogenic Fungi.

The current increase in resistance to antifungal drugs indicates that there is an urgent need to explore novel antifungal drugs with different mechanisms of action. Phosundoxin is a biphenyl aliphatic amide using a TPP-targeting strategy which targets mitochondria. To provide insights into the antifungal activities of phosundoxin, the antifungal susceptibility testing of phosundoxin was conducted on 158 pathogenic fungi and compared to that of traditional azole drugs.

Determination of lithium ions by stripping voltammetry using single-crystal LiFePO.

Determination of lithium ions is very important for extraction of lithium from salt lakes. Electrochemical sensor is an ideal choice, but it is not available so far. Here, a voltammetric sensor based on lithium iron phosphate (LiFePO) was developed.

Multistimuli-responsive multicolor solid-state luminescence tuned by NH-dependent switchable hydrogen bonds.

Revealing the stimuli-responsive mechanism is the key to the accurate design of stimuli-responsive luminescent materials. We report herein the multistimuli-responsive multicolor solid-state luminescence of a new dicopper(I) complex [{Cu(bpmtzH)}(μ-dppa)](ClO) (1), and the multistimuli-responsive mechanism is clarified by investigating its four different solvated compounds 1·2CHCOCH·2HO, 1·2DMSO·2HO, 1·4CHOH, and 1·4CHCl. It is shown that luminescence mechanochromism is associated with the breakage of the hydrogen bonds of bmptzH-NH with counter-ions such as ClO induced by grinding, while luminescence vapochromism is attributable to the breaking and forming of hydrogen bonds of dppa-NH with solvents, such as acetone, dimethylsulfoxide, and methanol, caused by heating and vapor fuming.

Phenotypic and Genomic Characteristics of sp. nov. Isolated from the Stomachs of Pigs in Beijing.

is among the four main causes of gastroenteritis worldwide. Most reported infections are caused by and . However, other emerging pathogens have been recognized as important pathogens in humans and animals.

Research on the Dynamic Characteristics of Perfluoroalkoxy Alkane Springs.

Semiconductor cleaning system ultra-clean flow control pumps are critical equipment in the semiconductor industry. Among them, the perfluoroalkoxy alkane (PFA) spring is a pivotal component to control the pump, and its dynamic performance is crucial to ensure the efficient operation of the system. However, the dynamic performance of the spring is often affected by the operating frequency.

Maternal supplementation with human milk-derived WLPL04 affects the immunity and gut microbiota of offspring rats.

Pregnancy and lactation are a window period during which interventions on mothers bring beneficial effects to newborns. This study aims to investigate the effects of maternal supplementation with human-milk-derived WLPL04-36e during pregnancy and lactation on the physiology, immunity and gut microbiota of dams and their offspring. We found that after maternal supplementation, WLPL04-36e could be detected in the intestines and extraintestinal tissues (liver, spleen, kidneys, mammary gland, MLN and brain) of dams, as well as in the intestines of their offspring.

Clinical relevance and distribution of virulence factors in isolates from Chinese patients.

Background: At present, the relationship between virulence factors of () and gastrointestinal diseases is still under discussion. This study investigated the association between distinct virulence factors in and different gastrointestinal diseases.

Methods: Gastric biopsy specimens were obtained from 160 patients with different gastrointestinal diseases in China, including 77 patients with chronic gastritis (CG), 36 with peptic ulcer disease (PUD), and 38 with gastric carcinoma (GC).

RdxA Diversity and Mutations Associated with Metronidazole Resistance of .

Metronidazole (MNZ) is administered as first-line antibiotic for Helicobacter pylori eradication therapy; however, increasing resistance to MNZ impaired the efficacy. Increasing the dose of MNZ was recommended to overcome low-level resistance, but it was difficult to determine MNZ resistance level simply based on the gene mutation. In this study, the sequences of 511 clinical H.

Efficacy of Active Rapid Molecular Screening and IPC Interventions on Carbapenem-Resistant Infections in Emergency Intensive Care Units without Enough Single-Room Isolation.

Purpose: To investigate whether rapid active molecular screening and infection prevention and control (IPC) interventions can reduce colonization or infection with carbapenem-resistant (CRE) in a general emergency intensive care unit (EICU) without enough single-room isolation.

Methods: The study was designed as a before-and-after quasi-experiment. Before the experimental period, the ward was rescheduled and the staff were trained.

DNA starvation/stationary phase protection protein of Helicobacter pylori as a potential immunodominant antigen for infection detection.

Background: Application of chicken egg yolk immunoglobulin Y (IgY) for Helicobacter pylori (H. pylori, HP) has gained much interest in recent years. Comparing with for treatment, IgY may be more advantageous when used for H.