Multi-Omics Analysis of the Gut-Brain Axis Elucidates Therapeutic Mechanisms of Guhong Injection in the Treatment of Ischemic Stroke.

Guhong injection (GH) is a compound preparation widely utilized in the treatment of cerebrovascular diseases. Accumulating evidence indicates that the gut microbiota is implicated in the development of ischemic stroke (IS). However, although the therapeutic potential of GH in IS may be mediated through the gut microbiota, the intricate relationships among the gut-brain axis, biomarkers, and target proteins remain to be completely explained.

Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway.

Nanoplastics (NPs) are an emerging class of pollutants. They can act as a"Trojan horse" to change the bioavailability and toxicity of heavy metals in the environment. However, research on the combined toxicity of heavy metals and NPs is scarce, especially during the critical developmental period of adolescence.

P101 Ameliorates TiO NP-Induced Bone Injury in Young Rats by Remodeling the Gut Microbiota and Inhibiting the Production of Pro-Inflammatory Cytokines.

Purpose: To evaluate the therapeutic effect of oral administration of P101 (P101) on skeletal injury in young rats exposed to titanium dioxide nanoparticles (TiO NPs), and explore the potential mechanism.

Methods: Four-week-old male rats were orally administration to TiO NPs and supplemented with P101 2 hours later for 4 weeks. The growth and development, food intake, bone metabolism and serum inflammatory markers of the rats were evaluated.

Ghrelin alleviated TiO NPs-induced inhibition of endochondral osteogenesis and promoted longitudinal growth of long bones in juvenile rats via Wnt/β-catenin signaling pathway.

Titanium dioxide nanoparticles (TiO NPs) are widely used in children's daily necessities and foods, and their health hazards to children have attracted particular attention. Childhood is a critical time for accelerated bone growth and development. Current studies revealed that TiO NPs exposure causes bone damage in juvenile rats; however, the underlying mechanism is unknown.

The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.

The current study aimed to evaluate the preventive effects of urolithin C (Uro C), a gut microbial metabolite of ellagitannins on D-galactose (D-gal)-induced brain damage during the aging process and to elucidate the underlying mechanisms. In our study, the protective effect of Uro C on D-gal-induced BV2 microglia cell-mediated neuroinflammation damage in primary cortical neurons in vitro was confirmed. The results in an aging model in vivo induced by D-gal demonstrated that Uro C prevented D-gal-induced memory impairment, long-term potentiation (LTP) damage, and synaptic dysfunction through behavioral, electrophysiological, and histological examinations.

A Na-Free Surface Enables "Three-In-One" Enhancement of Structural, Interfacial and Air Stability for Sodium-Ion Battery Cathodes.

O3-type layered oxides are regarded as one of the most promising cathode materials for sodium-ion batteries. However, the multistep phase transitions, severe electrode/electrolyte parasitic reactions, and moisture sensitivity are challenging for their practical application because of the highly active Na. Here, a Na-free layer is built on the surface of NaNiMnFeO (NMF111) via a leaching treatment and the subsequent surface reconstruction.

An Active Strategy to Reduce Residual Alkali for High-Performance Layered Oxide Cathode Materials of Sodium-Ion Batteries.

Residual alkali is one of the biggest challenges for the commercialization of sodium-based layered transition metal oxide cathode materials since it can even inevitably appear during the production process. Herein, taking O3-type NaNiMnFeMgTiO as an example, an active strategy is proposed to reduce residual alkali by slowing the cooling rate, which can be achieved in one-step preparation method. It is suggested that slow cooling can significantly enhance the internal uniformity of the material, facilitating the reintegration of Na into the bulk material during the calcination cooling phase, therefore substantially reducing residual alkali.

Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition.

The increasing prevalence of obesity and type 2 diabetes (T2D) signifies the failure of conventional treatments for these diseases. The gut microbiota has been proposed as a key player in the pathophysiology of diet-induced T2D. Urolithin B (Uro B), a gut microbiota-derived polyphenol metabolite, exerts several beneficial health effects.

Tuning the Solvation Structure in Water-Based Solution Enables Surface Reconstruction of Layered Oxide Cathodes toward Long Lifespan Sodium-Ion Batteries.

Layered oxides of sodium-ion batteries suffer from severe side reactions on the electrode/electrolyte interface, leading to fast capacity degradation. Although surface reconstruction strategies are widely used to solve the above issues, the utilization of the low-cost wet chemical method is extremely challenging for moisture-sensitive Na-based oxide materials. Here, the solvation tuning strategy is proposed to overcome the deterioration of NaNiMnFeO in water-based solution and conduct the surface reconstruction.

Maternal F-53B exposure during pregnancy and lactation induced glucolipid metabolism disorders and adverse pregnancy outcomes by disturbing gut microbiota in mice.

In the metal plating industry, F-53B has been widely used for almost half a century as a replacement for perfluorooctane sulfonate. However, F-53B can reach the food chain and affect human health. Pregnant women have distinct physiological characteristics and may thus be more sensitive to the toxicity of F-53B.

Comprehensive characterization of pyroptosis phenotypes with distinct tumor immune profiles in gastric cancer to aid immunotherapy.

Objective: Pyroptosis is a form of programmed cell death that is essential for immunity. Herein, this study was conducted to uncover the implication of pyroptosis in immunomodulation and tumor microenvironment (TME) in gastric cancer.

Methods: Prognostic pyroptosis-related genes were extracted to identify different pyroptosis phenotypes and pyroptosis genomic phenotypes via unsupervised clustering analysis in the gastric cancer meta-cohort cohort (GSE15459, GSE62254, GSE84437, GSE26253 and TCGA-STAD).

Haplotype Analysis Sheds Light on the Genetic Evolution of the Powdery Mildew Resistance Locus in Species.

Wheat powdery mildew ( f. sp. , , recently clarified as s.

Pretreatment of septic tank wastewater by packed anaerobic baffled reactor: Pollutant degradation and microbial community succession in different compartments.

Anaerobic baffled reactor (ABR) is widely used in rural sewage treatment due to its unique structure, strong impact load resistance, and low energy consumption. However, there is a lack of research on pollutant degradation patterns and microbial community succession patterns in each compartment of ABR. In this study, a packed anaerobic baffled reactor (PABR) was constructed.

Hollow and nanoporous Ag sub-microcubes as SERS substrates.

In this work, Ag(NH)NO microcubes are obtained by directly evaporating the silver ammonia complex solution. In NaCit solution, each Ag(NH)NO microcube can crumble into lots of AgCit sub-microcubes with uniform size, which serve as sacrificial templates to yield Ag sub-microcages. The as-obtained Ag cages possess ultra-high surface-enhanced Raman scattering (SERS) sensitivity towards R6G and thiram.

The importance of rest phase and pollutant removal mechanism of tidal flow constructed wetlands (TFCW) in rural grey water treatment.

This paper explored the effects of the rest phase of tidal flow constructed wetlands (TFCW) on pollutant removal and microbial communities, and further analyzed the mechanism of TFCW removal of pollutants from grey water. The results showed that the removal rate of organic matter was 69.91 ± 2.

Effects of iron-based substrate on coupling of nitrification, aerobic denitrification and Fe(II) autotrophic denitrification in tidal flow constructed wetlands.

The aerobic properties of nitrification and the anaerobic properties of denitrification in constructed wetlands are difficult to reconcile. In this study, two constructed wetlands were constructed with pyrite and steel slag in combination with zeolite, and their respective nitrification and denitrification capacities were evaluated under different tidal strategies. The steel slag wetland achieved 70.

A Novel Exosome-Relevant Molecular Classification Uncovers Distinct Immune Escape Mechanisms and Genomic Alterations in Gastric Cancer.

Gastric cancer (GC) is a highly heterogeneous malignant carcinoma. This study aimed to conduct an exosome-based classification for assisting personalized therapy for GC. Based on the expression profiling of prognostic exosome-related genes, GC patients in The Cancer Genome Atlas (TCGA) cohort were classified using the unsupervised consensus clustering approach, and the reproducibility of this classification was confirmed in the GSE84437 cohort.

Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors.

The aminobenzamide is selective to class I histone deacetylases (HDACs) and displays unique tight-binding/slow-off HDAC-binding mechanism. Herein, we report a series of 9-substituted purine aminobenzamides that selectively inhibit class I HDACs. The activities in vitro showed compound 9d exhibited 12 folds more potent than MS-275 against HDAC1 isoform and showed excellent inhibitory activity on cancer cells, including HCT-116, MDA-MB-231, K562 cell lines.

Identification and Mapping of QTL for Stripe Rust Resistance in the Chinese Wheat Cultivar Shumai126.

Stripe rust, caused by f. sp. , is a damaging disease of wheat globally, and breeding resistant cultivars is the best control strategy.

TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIF Pathway.

TRAF6 has been reported to be associated with poor prognosis in non-small-cell lung cancer (NSCLC). However, its precise role in tumor development has not been elaborated. In the present study, the function and the mechanism by which TRAF6 contributes to development were intensively investigated.