Publications by authors named "Lihong Lin"

The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers a promising alternative by reducing the bacterial adaptability to antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due to poor hydrophilicity of photosensitizers, short lifespan, narrow diffusion radius of reactive oxygen species (ROS), and the risk of exacerbating inflammation.

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Seborrheic dermatitis (SD), an inflammatory dermatosis, significantly lowers quality of life, particularly in the elderly. Although studies have focused on the burden of SD globally before, trends among people 55 and older have received less attention. Utilizing the data released in 2021 by the Global Burden of Disease (GBD) consortium, our research was conducted to evaluate the global, regional, and national burden of SD in adults over 55 between 1990 and 2021 through incidence, prevalence, and disability-adjusted life years (DALYs) alongside advanced methods such as joinpoint regression analysis.

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It is still a challenge to use a fast and efficient method for preserving fresh-cut fruits from browning. To address this problem, we developed konjac glucomannan (KGM) incorporated with elderberry anthocyanins (EA) to form film-forming solution (KEA) combined with polyvinylpyrrolidone (PVP) solution to produce KEA/PVP fiber films by microfluidic blow spinning (MBS). The introduction of PVP and EA improved the spinnability and function properties of KGM-based fiber film, respectively.

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Article Synopsis
  • Microplastics contamination in agricultural soils affects carbon and nitrogen cycles, leading to altered greenhouse gas emissions.
  • The presence of microplastics decreases soil water retention, which results in increased CO, CH₄, and NO emissions, while also enhancing soil structure and organic carbon storage.
  • Changes in microbial communities due to microplastics impact enzyme activity related to carbon and nitrogen processes, further complicating greenhouse gas dynamics and highlighting the need for better environmental management.
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Background: Peripheral artery disease (PAD) affects millions globally, causing significant morbidity. Traditional treatments like plain old balloon angioplasty (POBA) have limited success due to high restenosis rates. Drug-coated balloon angioplasty (DCBA) has emerged as a promising alternative, locally delivering antiproliferative drugs like paclitaxel to reduce restenosis.

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  • - This study created a biochar-loaded material with nitrogen-fixing bacteria (BAc) to reduce cadmium (Cd) levels in soil and promote plant growth, specifically in lettuce.
  • - BAc enhanced Cd adsorption by forming stable complexes and activating beneficial biochar groups, leading to significant increases in nitrogen uptake (up to 72.47%) and biomass (up to 107.32%).
  • - Additionally, BAc improved the microbial community in the soil, increasing diversity and promoting organisms that assist with nitrogen fixation and Cd immobilization, while also lowering Cd bioavailability by up to 46.42%.
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Endometriosis is a chronic inflammatory disease and an estrogen-dependent disease, so dietary factors that can modulate estrogen activity may be clinically important. Dietary fiber, widely distributed in vegetables and fruits, is closely associated with a plant-based diet. Therefore, this study aims to analyze and explore the relationship between dietary fiber intake and the risk of endometriosis providing insights for future clinical significance and treatment approaches.

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Background: While several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and atopic dermatitis remains limited. Our cross-sectional study seeks to examine the association between SII and atopic dermatitis among outpatient US adults.

Methods: This compensatory cross-sectional study utilized NHANES data from 2001-2006 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of sub-groups.

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It is still difficult for a single antibacterial modality to realize satisfactory management of bacterial breeding in food preservation. To solve this problem, we developed a photothermal-derived dual-mode synergistic bactericidal konjac glucomannan (KGM)/polycaprolactone (PCL) bilayer film incorporated with quercetin-loaded melanin-like nanoparticles (Q@MNPs). The results showed that the mechanical properties (TS: 29.

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Background: Psoriasis is a chronic dermatological condition characterized by a complex pathogenesis that impacts approximately 3% of adults in the United States and brings enormous social burdens. For many diseases, the systemic immune-inflammatory index (SII), defined as neutrophils × platelets/lymphocytes, has been recognized as a prognostic indicator. Therefore, we conducted a cross-sectional study to assess the association between SII and psoriasis among outpatient US adults.

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In the severe pollution area of nanoplastics (NPs) and cadmium ions (Cd), the joint effects of their high environmental concentrations on primary producers may differ from those of low environmental doses. Thus, we investigated the physiological changes, cell morphology, molecular dynamic simulation, phenotypic interactions, and metabolomics responses of C. pyrenoidosa to high environmental concentrations of NPs and Cd after 12-d acclimation.

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Microplastics (MPs) and heavy metals often coexist in soil, drawing significant attention to their interactions and the potential risks of biological accumulation in the soil-plant system. This paper comprehensively reviews the factors and biochemical mechanisms that influence the uptake of heavy metals by plants, in the existence of MPs, spanning from rhizospheric soil to the processes of root absorption and transport. The paper begins by introducing the origins and current situation of soil contamination with both heavy metals and MPs.

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Cadmium (Cd) is a toxic heavy metal often found in soil and agricultural products. Due to its high mobility, Cd poses a significant health risk when absorbed by crops, a crucial component of the human diet. This absorption primarily occurs through roots and leaves, leading to Cd accumulation in edible parts of the plant.

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Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study presents an initial analysis of the thermal-oxidative aging process of plastic shedding from feeding bottles, and investigates the inflammatory response induced by these atypical MPs in human intestinal cells (Caco-2). The PP-IFBs' surface displayed non-uniform white patches and increased roughness, revealing substantial structural alteration and shedding, especially during actions such as shaking, boiling water disinfection, and microwave heating.

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Security utilization measures (SUMs) for "production while remediating" in moderate and mild Cd-polluted paddy fields had been widely used. To investigate how SUMs drove rhizosphere soil microbial communities and reduced soil Cd bioavailability, a field experiment was conducted using soil biochemical analysis and 16S rRNA high-throughput sequencing. Results showed that SUMs improved rice yield by increasing the number of effective panicles and filled grains, while also inhibiting soil acidification and enhancing disease resistance by improving soil enzyme activities.

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Article Synopsis
  • Tree peony (Paeonia ostii), native to China, is an important ornamental plant known for its seed oil rich in unsaturated fatty acids like α-linolenic acid (ALA).
  • Research presents a detailed chromosome-level genome assembly of tree peony, revealing that it hasn't experienced whole-genome duplication but instead underwent significant LTR expansion in intergenic regions.
  • Genome-wide association studies identify key genes involved in ALA synthesis and suggest genetic factors influencing petaloid stamen formation, providing valuable insights for tree peony breeding and genome evolution studies.*
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Background: Globally, the incidence and mortality of colorectal cancer (CRC) rank amongst the highest of all malignancies. Thus, research aimed at developing new screening strategies and biomarkers for the early detection of CRC is needed. At present, conventional screening methods have limitations; therefore, new testing strategies have been considered.

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Background: Colorectal cancer (CRC) is a common global malignancy associated with high invasiveness, high metastasis, and poor prognosis. CRC commonly metastasizes to the liver, where the treatment of metastasis is both difficult and an important topic in current CRC management.

Methods: Microarrays data of human CRC with liver metastasis (CRCLM) were downloaded from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database to identify potential key genes.

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  • Researchers developed and validated nomograms to predict 5-year overall survival (OS) and disease-free survival (DFS) in cervical cancer patients with specific disease stages (IB1, IB2, IIA1) based on the FIGO 2018 classification.
  • The study involved 4,065 patients from 47 hospitals, with a model constructed using 75% of the data and validated with the remaining 25%, utilizing various clinicopathological factors analyzed through a Cox regression model.
  • Results showed that the nomograms outperformed the existing FIGO 2018 staging system in predicting survival outcomes, demonstrating higher concordance index (C-index) and area under the curve (AUC) in both the development and validation cohorts
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  • Ureaplasma urealyticum (UU) is a common bacteria in the human reproductive system that can cause infections, highlighting the need for quick detection methods.* -
  • A new real-time fluorescence loop-mediated isothermal amplification (LAMP) assay was developed for detecting UU, using specific primers for ureaseB genes and monitored in a controlled temperature setup.* -
  • The LAMP method showed high sensitivity and specificity, successfully detecting UU in all tested clinical samples, proving to be a better alternative to traditional PCR techniques.*
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  • - The study investigated whether surgical patients with stage IB1-IIA2 cervical cancer benefit from having a para-aortic lymphadenectomy (removal of lymph nodes) alongside other surgical procedures.
  • - A comparison was made between two groups of patients (8,802 in total) to see if those who had the para-aortic lymphadenectomy experienced better survival rates than those who did not.
  • - Findings showed no significant difference in 5-year survival outcomes regardless of whether para-aortic lymphadenectomy was performed, suggesting that it isn't recommended, particularly for patients without pelvic lymph node metastasis.
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Objective: To determine the accuracy of uterine corpus invasion (UCI) diagnosis in patients with cervical cancer and identity risk factors for UCI and depth of invasion.

Methods: Clinical data of patients with cervical cancer who underwent hysterectomy between 2004 and 2016 were retrospectively reviewed. UCI was assessed on uterine pathology.

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Objective: To explore the serological feature and molecular mechanism for a case with A307 subgroup of the ABO blood group system.

Methods: Serological assay was carried out to determine the ABO blood group of the proband and his family members. Genotypes for exons 1 to 7 of the ABO gene were determined with sequence-specific primer polymerase chain reaction (SSP-PCR) and direct sequencing.

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