Publications by authors named "Lihini Tharanga Mendis"
Anal Chim Acta
November 2024
Article Synopsis
- Single cell mass spectrometry (scMS) is a promising technique for analyzing proteins from individual cells, but current methods are limited by high costs and sequential processing that reduce throughput.
- This study introduces a new method that allows for the simultaneous processing of 10 single cells using 3D printed microfluidic devices and a magnetic beads-based workflow, eliminating the need for expensive robotic liquid handlers.
- The method not only shows consistent quantification across samples but also proves effective in distinguishing different cell lines and assessing proteome changes due to drug treatment, making it a significant advance in single cell proteomics.
