Heterogeneous nucleation in the random field Ising model.

We investigate the nucleation dynamics of the three-dimensional random field Ising model under an external field. We use umbrella sampling to compute the free-energy cost of a critical nucleus and use forward flux sampling for the direct estimation of nucleation rates. For moderate to strong disorder, our results indicate that the size of the nucleating cluster is not a good reaction coordinate, contrary to the pure Ising model.

HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma.

Tumor necrosis factor receptor 1 (TNFR1) signaling plays a pleiotropic role in the development of hepatocellular carcinoma (HCC). The formation of TNFR1-complex I supports cell survival while TNFR1-complex II leads to apoptosis, and the underlying mechanisms of the transformation of these TNFR1 complexes in HCC remain poorly defined. The interaction protein of TNFR1 was identified by GST pulldown assay, immunoprecipitation and mass spectrometry.

Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes.

Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown. Using integrative analyses of multi-omics data, transferrin receptor 1 (Tfr1) is identified as a candidate for regulating thermogenesis in beige adipocytes.

The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma.

TCP1 ring complex (TRiC) participates in protein folding in cells, regulating the expression of many tumor-related proteins and the cell cycle. Although the clinical significance of its subunits has been widely discussed in various malignancies, limited studies have explored its function in hepatocellular carcinoma (HCC) in the perspective of a complex. This study discusses the clinical significance of the TRiC subunits in HCC patients in terms of expression level, prognostic value, and potential mechanism.

Increased mediator complex subunit 15 expression is associated with poor prognosis in hepatocellular carcinoma.

Mediator complex subunit 15 (MED15) is a coactivator involved in the regulated transcription of RNA polymerase II-dependent genes and serves an oncogenic role in numerous types of cancer. However, the expression and function of MED15 in hepatocellular carcinoma (HCC) remain unknown. In the present study, the aim was to investigate the expression and clinical significance of MED15 in HCC.

Thermal-independent properties of PIN-PMN-PT single-crystal linear-array ultrasonic transducers.

In this paper, low-frequency 32-element linear-array ultrasonic transducers were designed and fabricated using both ternary Pb(In(1/2)Nb(1/2))-Pb(Mg(1/3)Nb(2/3))-PbTiO(3) (PIN-PMN-PT) and binary Pb(Mg(1/3)Nb(2/3))-PbTiO(3) (PMNPT) single crystals. Performance of the array transducers was characterized as a function of temperature ranging from room temperature to 160°C. It was found that the array transducers fabricated using the PIN-PMN-PT single crystal were capable of satisfactory performance at 160°C, having a -6-dB bandwidth of 66% and an insertion loss of 37 dB.