Publications by authors named "Lihao Wan"
Ligand-induced receptor and co-receptor heterodimerization is a common mechanism in receptor kinase (RK) signalling activation. SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) mediate the complex formation of Arabidopsis RK MIK2 and co-receptor BAK1, triggering immune responses. Through structural, biochemical and genetic analyses, we demonstrate that SCOOPs use their SxS motif and adjacent residues to bind MIK2 and the carboxy-terminal GGR residues to link MIK2 to BAK1.
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- Ergosterols are vital for fungal cell membranes, and targeting the genes responsible for their biosynthesis is key to managing fungal diseases like rice blast caused by Magnaporthe oryzae.
- The Trm6/Trm61 complex adds a specific modification (mA58) to tRNAs, which plays a crucial role in speeding up protein synthesis by enhancing the binding of tRNA to the ribosome during translation.
- Disrupting this mA58 process reduces the production of ergosterols and weakens fungal virulence, suggesting that a combined approach targeting both mA58 modification and ergosterol biosynthesis could be effective in developing new fungicides.
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- Cancer cells, particularly glioma stem cells (GSCs), have higher ribosome production rates than normal cells, which helps them grow quickly in tumors; the study identifies a factor called NIR that promotes this process in GSCs.
- Using various experimental techniques, researchers found that NIR is linked to poor survival rates in glioblastoma patients and is crucial for the proliferation of GSCs and tumor growth by facilitating the transcription of ribosomal DNA.
- The findings suggest that NIR could be a promising target for new therapies against glioblastoma by inhibiting its role in ribosome production and, consequently, tumor progression.
Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development. Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase. SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
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