LncRNA HAGLROS: A Vital Oncogenic Propellant in Various Human Cancers.

HAGLR Opposite Strand lncRNA (HAGLROS) is a long non-coding RNA (lncRNA) located on the long arm of human chromosome 2 at locus 2q31.1. Emerging evidence highlights HAGLROS as a pivotal player in human cancers, characterized by its significant upregulation across multiple malignancies where it functions as an oncogenic driver.

B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis.

Transforming growth factor (TGF)-β signaling is critical for epithelial-mesenchymal transition (EMT) and colorectal cancer (CRC) metastasis. Disruption of Smad-depednent TGF-β signaling has been shown in CRC cells. However, TGF-β receptor remains expressed on CRC cells.

Hybrid Eu(II)-bromide scintillators with efficient 5d-4f bandgap transition for X-ray imaging.

Luminescent metal halides are attracting growing attention as scintillators for X-ray imaging in safety inspection, medical diagnosis, etc. Here we present brand-new hybrid Eu(II)-bromide scintillators, 1D type [EtN]EuBr·MeOH and 0D type [MeN]EuBr·MeOH, with spin-allowed 5d-4f bandgap transition emission toward simplified carrier transport during scintillation process. The 1D/0D structures with edge/face -sharing [EuBr] octahedra further contribute to lowing bandgaps and enhancing quantum confinement effect, enabling efficient scintillation performance (light yield ~73100 ± 800 Ph MeV, detect limit ~18.

Invariant contexts reduce response time variability in visual search in an age-specific way: A comparison of children, teenagers, and adults.

Contextual cueing is a phenomenon in which repeatedly encountered arrays of items can enhance the visual search for a target item. This is widely attributed to attentional guidance driven by contextual memory acquired during visual search. Some studies suggest that children may have an immature ability to use contextual cues compared to adults, while others argue that contextual learning capacity is similar across ages.

Common intentional binding effects across diverse sensory modalities in touch-free voluntary actions.

The intentional binding effect refers to the phenomenon where the perceived temporal interval between a voluntary action and its sensory consequence is subjectively compressed. Prior research revealed the importance of tactile feedback from the keyboard on this effect. Here we examined the necessity of such tactile feedback by utilizing a touch-free key-press device without haptic feedback, and explored how initial/outcome sensory modalities (visual/auditory/tactile) and their consistency influence the intentional binding effect.

Contingent magnetic variation and beta-band oscillations in sensorimotor temporal decision-making.

The ability to accurately encode the temporal information of sensory events and hence to make prompt action is fundamental to humans' prompt behavioral decision-making. Here we examined the ability of ensemble coding (averaging multiple inter-intervals in a sound sequence) and subsequent immediate reproduction of target duration at half, equal, or double that of the perceived mean interval in a sensorimotor loop. With magnetoencephalography (MEG), we found that the contingent magnetic variation (CMV) in the central scalp varied as a function of the averaging tasks, with a faster rate for buildup amplitudes and shorter peak latencies in the "half" condition as compared to the "double" condition.

Improving the efficiency and environmental safety of emamectin benzoate through a pH-responsive metal-organic framework microencapsulation strategy.

Herein, we developed a technique for loading nanopesticides onto Metal-Organic Frameworks (MOFs) to control Spodoptera litura. The average short-axis length of the synthesized carrier emamectin benzoate@PCN-222 @hyaluronic acid (EB@PCN-222 @HA) was ∼40 nm, with an average long-axis length of ∼80 nm. This enabled the manipulation of its size, contact angle, and surface tension on the surface of leaves.

The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis.

Background: CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3'UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.

Effects of adding Bacillus subtilis natto NTU-18 in paste feed on growth, intestinal morphology, gastrointestinal microbiota diversity, immunity, and disease resistance of Anguilla japonica glass eels.

Japanese eel, Anguilla japonica, holds significant importance in Taiwanese aquaculture. With the intensification of eel farming, the impact of Edwardsiella tarda has become increasingly severe. Consequently, the abusive use of antibiotics has risen.

Atmospheric CO in the megacity Hangzhou, China: Urban-suburban differences, sources and impact factors.

Limited observation sites and insufficient monitoring of atmospheric CO in urban areas restrict our comprehension of urban-suburban disparities. This research endeavored to shed light on the urban-suburban differences of atmospheric CO in levels, diurnal and seasonal variations as well as the potential sources and impact factors in the megacity of Hangzhou, China, where the economically most developed region in China is. The observations derived from the existing Hangzhou Atmospheric Composition Monitoring Center Station (HZ) and Lin'an Regional Atmospheric Background Station (LAN) and the newly established high-altitude Daming Mountain Atmospheric Observation Station (DMS), were utilized.

Synesthetic Correspondence: An Overview.

Intramodal and cross-modal perceptual grouping based on the spatial proximity and temporal closeness between multiple sensory stimuli, as an operational principle has built a coherent and meaningful representation of the multisensory event/object. To implement and investigate the cross-modal perceptual grouping, researchers have employed excellent paradigms of spatial/temporal ventriloquism and cross-modal dynamic capture and have revealed the conditional constraints as well as the functional facilitations among various correspondence of sensory properties, with featured behavioral evidence, computational framework as well as brain oscillation patterns. Typically, synesthetic correspondence as a special type of cross-modal correspondence can shape the efficiency and effect-size of cross-modal interaction.

[Characteristics and Influencing Factors of Greenhouse Fluxes from Urban Lawn].

As an important component of urban green spaces, greenhouse gas uptake or emissions from urban lawns cannot be ignored. However, studies of greenhouse gas fluxes from subtropical urban lawns are relatively sparse. The static chamber-gas chromatography method was applied to monitor the ground-air exchange fluxes of various greenhouse gases(CO, CH, NO, and CO) in typical urban lawns of Hangzhou City.

Estimation of the distribution patterns of heavy metal in soil from airborne hyperspectral imagery based on spectral absorption characteristics.

Though soil is widely known as one of the most valuable resources for the world, its quality is going to be lower because of unsustainable economic development and social progress. Therefore, it is important for us to monitor and evaluate the quality of soil, especially its heavy metal contents which is too scarce to identify in soil spectra easily but poisonous enough to affect human health in a long run. Most of the existing estimation methods have based the characteristic bands on statistical analysis to a large extent, which is hard to accurately explain the retrieval mechanism.

Plant-based polyphenol rich protein supplementation attenuated skeletal muscle loss and lowered the LDL level gut microbiota remodeling in Taiwan's community-dwelling elderly.

Sarcopenia, characterized by muscle loss, negatively affects the elderly's physical activity and survival. Enhancing protein and polyphenol intake, possibly through the supplementation of fermented black soybean koji product (BSKP), may alleviate sarcopenia by addressing anabolic deficiencies and gut microbiota dysbiosis because of high contents of polyphenols and protein in BSKP. This study aimed to examine the effects of long-term supplementation with BSKP on mitigating sarcopenia in the elderly and the underlying mechanisms.

Reward delays quitting in visual search.

Reward motivates goal-directed behaviors, leading to faster reaction time (RT) and lower error rate in searching for a target in the reward condition than in the no-reward condition in target-discrimination tasks. However, it is unclear how reward influences target detection in which participants are required to judge whether a predesignated target is present or absent. Here, we asked participants to complete a target-detection search task in which the color of the search array indicated the reward availability of the current trial.

The speed and temporal frequency of visual apparent motion modulate auditory duration perception.

In the present study, we investigated how the perception of auditory duration could be modulated by a task-irrelevant, concurrent visual apparent motion, induced by visual bars alternating between left and right sides. Moreover, we examined the influence of the speed and temporal frequency of visual apparent motion on the perception of auditory duration. In each trial, the standard visual stimuli (two vertical bars) were presented sequentially, except that visual apparent motion was included in the fourth stimulus.

Pay Attention to the Ignorable Missing Data Mechanisms! An Exploration of Their Impact on the Efficiency of Regression Coefficients.

The use of modern missing data techniques has become more prevalent with their increasing accessibility in statistical software. These techniques focus on handling data that are (MAR). Although all MAR mechanisms are routinely treated as the same, they are not equal.

Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h.

Background: Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions.

Low Obesity-Related Indices Are Associated with a Low Baseline Calcaneus Ultrasound T-Score, and a Rapid Decline in T-Score in a Large Taiwanese Population Follow-Up Study.

Osteoporosis results in reduced bone strength and an elevated risk of fractures. Both overweight and underweight have been associated with osteoporosis; however, few studies have examined associations between osteoporosis and indices related to obesity. Therefore, the aim of this study was to investigate the associations of obesity-related indices, including body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), body adiposity index (BAI), abdominal volume index (AVI), lipid accumulation product (LAP), and visceral adiposity index (VAI), with baseline and change in calcaneus ultrasound T-score between baseline and follow-up (ΔT-score).

Intermodulation from Unisensory to Multisensory Perception: A Review.

Previous intermodulation (IM) studies have employed two (or more) temporal modulations of a stimulus, with different local elements of the stimulus being modulated by different frequencies. Brain activities of IM obtained mainly from electroencephalograms (EEG) have been analyzed in the frequency domain. As a powerful tool, IM, which can provide a direct and objective physiological measure of neural interaction, has emerged as a promising method to decipher neural interactions in visual perception, and reveal the underlying different perceptual processing levels.

Self-reference modulates the perception of visual apparent motion.

Visual apparent motion is a perceptual illusion where sequentially presented static stimuli containing no physically continuous motion are perceived as moving. In the current study, we examined whether and how self-reference, as a typical high-level information processing, could modulate perceptual categorization of the apparent motion in Ternus display, even when self-reference is task-irrelevant. Two frames were consecutively presented, with the first frame consisting of two identical stimuli (e.

Increasing audiovisual speech integration in autism through enhanced attention to mouth.

Autistic children (AC) show less audiovisual speech integration in the McGurk task, which correlates with their reduced mouth-looking time. The present study examined whether AC's less audiovisual speech integration in the McGurk task could be increased by increasing their mouth-looking time. We recruited 4- to 8-year-old AC and nonautistic children (NAC).