Theoretical and numerical study on transient acoustic wave propagation across ice layers in the Arctic Ocean.

The study of transient acoustic wave propagation across the Arctic Ocean ice layer provides theoretical guidance for the design of trans-ice acoustic communication systems. In this study, the Arctic Ocean was modeled as an ice-water composite structure, where the ice and water are regarded as an elastic solid and liquid, respectively. An analytical transient solution for acoustic wave propagation in this structure was derived using the eigenfunction expansion method.

SETBP1 mutation determines sensitivity to immune checkpoint inhibitors in melanoma and NSCLC.

SET binding protein 1 (SETBP1) plays crucial roles in various biological processes; however, its involvement in cancer immune checkpoint inhibitor (ICI) treatments has never been studied. In this study, we collected a total of 631 melanoma and 109 non-small cell lung cancer (NSCLC) samples treated with ICI agents (i.e.

Dried root of Rehmannia glutinosa extracts prevents steroid-induced avascular necrosis of femoral head by activating the wingless-type (Wnt)/β-catenin signal pathway.

Steroid-induced avascular necrosis of femoral head (SANFH) is one of the most common complications caused by long-term or excessive clinical use of glucocorticoids. This study aimed to investigate the effects of dried root of Rehmannia glutinosa extracts (DRGE) in SANFH. First, SANFH rat model was established by dexamethasone (Dex).

Knockdown of lncRNA JPX suppresses IL-1β-stimulated injury in chondrocytes through modulating an miR-25-3p/PPID axis.

The aim of this study was to investigate the potential mechanisms of long noncoding (lnc) RNA Just proximal to X-inactive specific transcript (JPX) in interleukin (IL)-1β-stimulated chondrocytes. Human C28/I2 chondrocytes were treated with IL-1β to simulate osteoarthritic (OA) injury. The expression levels of JPX, microRNA (miRNA/miR)-25-3p, and peptidylprolyl isomerase D (PPID) were measured using reverse transcription-quantitative PCR or western blotting.

Acoustic Properties of the Otolith of the Large Yellow Croaker (Perciformes: Sciaenidae).

The inner ears of fish contain three pairs of otoliths-lapilli, asterisci and sagittae-which play important roles in hearing and balance. However, acoustic properties and dynamic responses of fish otoliths are poorly understood. The large yellow croaker (), like many species in the family Sciaenidae, is extremely sensitive to sound.

Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF-κB pathway.

Background: Peripheral nerve injury (PNI) causes motor and sensory defects, has strong impact on life quality and still has no effective therapy. Miconazole is one of the most widely used antifungal drugs; the aims of the study were to investigate the effects of miconazole during sciatic nerve regeneration in a mouse model of sciatic nerve crush injury.

Methods: We established peripheral nerve crush model and investigated the effects of miconazole by multiple aspects.

Temperature dependence of dielectric, elastic, and piezoelectric constants of [001] poled Mn-doped 0.24Pb(InNb)O-0.46Pb(MgNb)O-0.30PbTiO single crystal.

In order to simulate the performance of electromechanical devices at elevated temperatures, full tensor properties of piezoelectric materials at high temperatures are needed. Such data are extremely difficult to get for relaxor-based single crystals because their properties are determined by domain structures, which are strongly geometry dependent. We report here the temperature dependence of full tensor material constants of [001] poled Mn-doped 0.

Temperature dependence of self-consistent full matrix material constants of lead zirconate titanate ceramics.

Up to date, there are no self-consistent data in the literature on the temperature dependence of full matrix material properties for piezoelectric materials because they are extremely difficult to determine. Using only one sample, we have measured the temperature dependence of full matrix constants of lead zirconate titanate (PZT-4) from room temperature to 120 °C by resonant ultrasound spectroscopy. Self-consistency is guaranteed here because all data at different temperatures come from one sample.