Publications by authors named "Ligia-Ancuta Hui"
Article Synopsis
- Linezolid shows significant variability in critically ill patients, affecting its plasma concentration and potentially its effectiveness, prompting the need for optimized dosing strategies.
- A study was conducted comparing two administration methods (intermittent infusion vs. continuous infusion) to assess their impact on pharmacokinetics and drug concentration in critically ill patients.
- Results indicated that continuous infusion led to more stable serum concentrations and better adherence to desired pharmacokinetic/pharmacodynamic indices, suggesting it could improve patient safety and outcomes compared to intermittent infusion.
A judicious antibiotic therapy is one of the challenges in the therapy of critically ill patients with sepsis and septic shock. The pathophysiological changes in these patients significantly alter the antibiotic pharmacokinetics (PK) and pharmacodynamics (PD) with important consequences in reaching the therapeutic targets or the risk of side effects. The use of linezolid, an oxazolidinone antibiotic, in intensive care is such an example.
View Article and Find Full Text PDFThe association between frailty, disability in activities of daily living (ADL), polypharmacy, and quality of life (QoL) in middle-aged patients with cardiovascular disease (CVD) is little investigated. This study sought (a) to explore this association comparatively in elderly and middle-aged hospitalized patients with CVD and (b) to determine which domains of ADL and QoL might improve the frailty prediction. A one-year follow-up study including 90 elderly (≥65 years old) and 89 middle-aged patients (40-65 years old) was conducted.
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