Expression and activation of intracellular receptors TLR7, TLR8 and TLR9 in peripheral blood monocytes from HIV-infected patients.

Introduction: TLR´s play a role in host defense in HIV infection recognizing the viral DNA or RNA. Their activation induces a signaling pathway that includes the proteins MyD88, IRAK4, TRAF6 and the transcription factor NF-kBp65.

Objective: To determine the expression of TLR7, TLR8 and TLR9, and activation of its signaling pathway in monocytes from patients infected with HIV.

[CCR5-Δ32 allele involvement in the clinical evolution of HIV1+ patients in Yucatán, Mexico].

Objective: CCR5-Δ32 allele frequency needs to be identified in HIV+ patients and exposed seronegative individuals in Yucatan, Mexico, to understand this mutation's relationship to infection and disease progression.

Material And Methods: A total of 355 samples were analyzed: 62 from HIV+ patients, 51 from exposed seronegative individuals and 242 from general population. Infected patients were subdivided into a) normal progressors n= 49; b) slow progressors n= 10, and c) non-progressors n= 3.

[Prevalence of iron-deficient anemia in rural pregnant women in Valldolid, Yucatan, Mexico].

Objective: To determine the prevalence of iron-deficiency anaemia among rural pregnant women in Valladolid, Yucatan, Mexico.

Materials And Methods: A descriptive study was carried out from March to May 2006. A clinical-epidemiological survey, a complete blood count test and a ferritin test were applied to a non-random sample conformed by 51 rural pregnant women.

[Acceptability of a test for antibodies against HIV in a group of pregnant women in Yucatan, Mexico].

Objective: To evaluate the acceptability of a test for antibodies against HIV (Ab-HIV) in a group of pregnant women in Yucatan, Mexico.

Patients And Methods: A clinical and epidemiological study was carried out on 310 pregnant women at different health centers in Yucatan Mexico, from January 2000 to March 2001. A questionnaire was applied to determine information in relation to HIV infection and acceptability of the test.