Epidemiology and characterization of isolated from hospitalized patients in southern Brazil: a possible emerging pathogen.

This study aimed to characterize the virulence factors and antimicrobial resistance of , an opportunistic pathogen that causes human infections. We examined 45 isolates of both genotypically and phenotypically by studying their adherence to HeLa cells, biofilm formation, cytotoxicity and antimicrobial resistance, and analysed their genomes for putative virulence and resistance genes. This study found that most isolates possessed multiple virulence genes, including A, A, A, A, A and A, and were cytotoxic to Vero cells.

Clonal relationship, virulence genes, and antimicrobial resistance of Morganella morganii isolated from community-acquired infections and hospitalized patients: a neglected opportunistic pathogen.

Morganella morganii is a bacterium belonging to the normal intestinal microbiota and the environment; however, in immunocompromised individuals, this bacterium can become an opportunistic pathogen, causing a series of diseases, both in hospitals and in the community, being urinary tract infections more prevalent. Therefore, the objective of this study was to evaluate the prevalence, virulence profile, and resistance to antimicrobials and the clonal relationship of isolates of urinary tract infections (UTI) caused by M. morganii, both in the hospital environment and in the community of the municipality of Londrina-PR, in southern Brazil, in order to better understand the mechanisms for the establishment of the disease caused by this bacterium.

Herpes simplex virus: isolation, cytopathological characterization and antiviral sensitivity.

Background: Herpes simplex virus (HSV) infection is an endemic disease and it is estimated that 6095% of the adult population are infected with symptoms that are usually self-limiting, though they can be serious, extensive and prolonged in immunocompromised individuals, highlighted by the emergence of drug-resistant strains. The study of the wild-type HSV strains based on the cytopathogenic features and its antiviral sensitivity are important in the establishment of an antivirogram for controlling the infection.

Objective: This study sought to isolate and examine the cytopathological characteristics of circulating strains of the Herpes simplex virus, from clinical specimens and their sensitivity to commercially available antiherpesvirus drugs, acyclovir, phosphonophormic acid and trifluridine.

Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions.

Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex virus and bovine herpes virus in HEp-2 cell cultures.

Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity.

In this study, we have analyzed the pectic arabinogalactan isolated from Azadirachta indica and its chemically sulfated derivative. The native polysaccharide had an apparent molecular mass of 80 kDa and is made up of (1→5)-/(1→3,5)-linked α-L-arabinosyl, (1→3)-/(1→6)-/(1→3,6)-linked β-D-galactosyl, and terminal-rhamnosyl and α-l-arabinosyl residues. These macromolecules showed activity against bovine herpesvirus type-1.