mA methylation: a potential key player in understanding and treating COVID-2019 infection.

Since its discovery in 2019, coronavirus disease 2019 (COVID-2019) spans a wide clinical spectrum from the asymptomatic stage, mild infection, to severe pneumonia. In patients with COVID-2019, factors such as advanced age, diabetes, or hypertension are associated with a significantly increased risk of severe diseases and death. Of note, the mechanisms underlying differences in the risk and symptoms of COVID-2019 among different populations are still poorly characterized.

Iodine-DEM TACE conventional TACE in cirrhotic patients with hepatocellular carcinoma: a single center experiment.

Background: To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) with iodine-doxorubicin-eluting gelatin microspheres (I-DEM TACE) compared with conventional TACE (cTACE) with polyvinyl alcohol foam (PVA) embolization microspheres.

Methods: A total of 22 patients diagnosed with hepatocellular carcinoma were equally divided into 2 groups. The patients who underwent TACE with I-DEM (25.

Modification of the method to establish a hepatic VX2 carcinoma model in rabbits.

The hepatic VX2 carcinoma model in rabbits is widely used for the preclinical study of hepatocellular carcinoma. In the present study, a modification was made to the conventional method to establish the animal model, as the conventional method gives rise to frequent tumor seeding due to the drop-out of tumor fragments. In order to evaluate each distinct method of establishing the model, the rabbits were divided into two groups: Group A (the conventional method; n=20) and group B (the modified method; n=20).

The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis.

The uncontrolled progression of the inflammatory cascade is the main cause underlying the development of multiple organ dysfunction syndrome (MODS) in acute pancreatitis. In this study, we investigated the effects of several immunosuppressants on mitigating the systemic inflammatory reaction syndrome (SIRS) and the compensatory anti-inflammatory response syndrome (CARS) associated with acute pancreatitis. A total of 93 male Sprague Dawley rats were divided into 5 groups: group 1 was the sham group and group 2 underwent laparoscopic intrapancreatic duct injection of sodium taurocholate to induce pancreatitis.

In vivo distribution of (131)I and (125)I dual-labeled gelatin microspheres after implantation into rabbit liver.

Objective: The purpose of this study was to explore the radionuclide distribution and metabolism of (131)I and (125)I dual-labeled gelatin microspheres ((131)I-(125)I-GMSs) implanted in rabbit liver.

Methods: The simultaneous radiolabeling of (131)I and (125)I into GMSs was performed by a chloramine-T method to prepare biodegradable dual-labeled radionuclide microspheres. The microspheres were injected into rabbit liver.

[Preparation and biological characteristics of a new doxorubicin-gelatin-microspheres for hepatic artery embolization].

Objective: To prepare a new doxorubicin-gelatin-microspheres (DR-GMs) suitable for hepatic artery chemoembolization.

Methods: Oxidized dextran and glutaraldehyde were used respectively as crosslinking agent for preparing DR-GMs. Orthogonal design was employed to optimize the preparation of the oxidized dextran cross-linked GMs.

Direct in vivo injection of 131I-GMS and its distribution and excretion in rabbit.

Aim: To explore the distribution and metabolism of (131)I-gelatin microspheres ((131)I-GMSs) in rabbits after direct injection into rabbits' livers.

Methods: Twenty-eight healthy New Zealand rabbits were divided into seven groups, with four rabbits per group. Each rabbit's hepatic lobes were directly injected with 41.

Regulatory effect of histamine on the barrier function of intestinal mucosal.

Objectives: To investigate the regulatory effect of histamine on the barrier function of intestinal mucosal.

Methods: The monolayer Caco-2 cell system in vitro and the model of hemorrhage infection in rats in vivo were established as experimental models. The amount of bacterial translocation was taken as an index of the effect of histamine and its receptor antagon, cimetidine on the intestinal mucosal barrier function.

Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis.

Aim: To investigate the effects of 5-Fluorouracil (5-FU) on modulation of pro-inflammatory and anti-inflammatory cytokines in acute pancreatitis and the mechanism of it in the treatment of acute pancreatitis.

Methods: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls (n = 7); Group B, acute pancreatitis induced by ductal injection with 5% sodium cholate at a volume of 1.0 mL/kg without any other treatment; Group C, after the pancreatitis was induced as in Group B, the rats were injected intravenously with 5-FU 40 mg/kg.