Publications by authors named "Lige Peng"
Article Synopsis
- - The study examined the prognostic value of chest pain in patients diagnosed with acute pulmonary embolism (APE) at West China Hospital from 2016 to 2019, involving 737 patients, 254 of whom (34.5%) reported chest pain at admission.
- - Patients with chest pain showed significantly lower rates of in-hospital and subsequent all-cause mortality (3.1% in-hospital mortality for those with chest pain vs. 11.2% for those without) and required less mechanical ventilation.
- - The findings suggest chest pain serves as an independent predictor of better outcomes in APE patients, indicating it could be a favorable prognostic marker for assessing mortality risks.
Aim: Venous thromboembolism (VTE) risk significantly increases in patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), which is characterized by an enhanced inflammatory response. This study aimed to evaluate the predictive value of inflammatory biomarkers for VTE in AECOPD.
Methods: A prospective, multicenter study was conducted to include patients hospitalized for AECOPD.
Introduction: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to intensive care unit (ICU) are exposed to poor clinical outcomes, and no specific prognostic models are available among this population. We aimed to develop and validate a risk score for prognosis prediction for these patients.
Methods: This was a multicenter observation study.
Background: Noninvasive mechanical ventilation (NIV) is recommended as the initial mode of ventilation to treat acute respiratory failure in patients with AECOPD. The Noninvasive Ventilation Outcomes (NIVO) score has been proposed to evaluate the prognosis in patients with AECOPD requiring assisted NIV. However, it is not validated in Chinese patients.
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- The study examined characteristics, treatments, and clinical outcomes of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in China, highlighting a need for more research on sex differences.
- A total of 14,007 AECOPD patients were analyzed, with females generally older and having more comorbidities, while also showing differences in treatment such as higher rates of ICU admission and antibiotic use compared to males.
- Despite these clinical differences, the overall in-hospital and long-term mortality rates were similar for both sexes, although female smokers had significantly higher in-hospital mortality compared to their male counterparts.
Article Synopsis
- A study investigated the high mortality rates among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and cardiovascular diseases (CVDs) to create a new risk score for predicting mortality.
- Using data from a large cohort, researchers developed the ABCDMP score, which includes key patient factors such as age, blood urea nitrogen levels, and vital signs to assess risk.
- The ABCDMP score demonstrated strong predictive power, outperforming existing risk scores, and can help guide treatment decisions and future clinical research for these patients.
Validation of the Rome Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbation: A Multicenter Cohort Study.
Int J Chron Obstruct Pulmon Dis
January 2024
Background: The Rome severity classification is an objective assessment tool for the severity of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) based on readily measurable variables but has not been widely validated. The aim of this study is to evaluate the validity of the Rome classification in distinguishing the severity of AECOPD based on short-term mortality and other adverse outcomes.
Methods: The Rome severity classification was applied to a large multicenter cohort of inpatients with AECOPD.
Article Synopsis
- High blood urea nitrogen (BUN) levels are observed in some patients with acute exacerbation of COPD (AECOPD) and may correlate with worse clinical outcomes, though past research has yielded mixed results.
- A study analyzed data from 13,431 AECOPD patients, finding that those who did not survive had significantly higher BUN levels (9.5 vs 5.6 mmol/L), establishing a BUN cutoff of 7.30 mmol/L as a predictor of in-hospital mortality.
- The findings indicate that elevated BUN is an independent risk factor for both in-hospital mortality and the need for intensive care, suggesting it could help in identifying and managing high-risk AECOPD patients.
Article Synopsis
- The study investigates the prognostic significance of diastolic blood pressure (DBP) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) to identify its relationship with negative health outcomes.
- A total of 13,633 AECOPD patients were examined, revealing that low DBP (<70 mmHg) on admission significantly increased the risk of in-hospital mortality, need for invasive mechanical ventilation, and ICU admission.
- The research indicates that as DBP decreases, the risk of mortality rises, highlighting the importance of monitoring DBP in AECOPD patients upon hospital admission.
Purpose: The prognostic value of blood eosinophils in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains controversial. This study aimed to evaluate whether blood eosinophils could predict in-hospital mortality and other adverse outcomes in inpatients with AECOPD.
Methods: The patients hospitalized for AECOPD were prospectively enrolled from ten medical centers in China.
Article Synopsis
- Hypocalcemia, defined as serum calcium levels ≤ 2.12 mmol/L, is linked to worse outcomes and higher mortality rates in patients with acute pulmonary embolism (APE).
- A study of 803 APE patients found that those with hypocalcemia had significantly higher in-hospital and 2-year mortality rates, enhancing the prediction accuracy of the European Society of Cardiology (ESC) prognostic algorithm when serum calcium levels were included.
- The findings suggest that serum calcium could become an important factor in risk assessment for APE patients, potentially improving management and patient outcomes.
Derivation and Validation of a Prognostic Model for Mortality in Chinese Patients with Acute Pulmonary Embolism.
Clin Appl Thromb Hemost
December 2022
Introduction: We aim to explore the risk factors for in-hospital mortality and to derive a prognostic model for patients with APE in China.
Materials And Methods: Inpatients with APE were enrolled from West China Hospital between January 2016 and December 2019. Logistic regression analyses were used to explore risk factors for in-hospital mortality and develop a prognostic model.
Article Synopsis
- - The study aimed to determine if D-dimer levels can effectively predict the risk of venous thromboembolism (VTE) in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), comparing it to the Padua Prediction Score (PPS).
- - Researchers enrolled 4,468 AECOPD patients from seven medical centers, finding that 2.01% developed VTE within two months; results showed D-dimer had a significantly higher predictive value than PPS for VTE risk.
- - The study concluded that D-dimer is a more reliable tool for predicting VTE than PPS, suggesting its use could improve thromboprophylaxis strategies in patients with AECOPD
BACKGROUND Infection with Echinococcus granulosus is endemic in sheep and dogs in Central Asia, including Tibet. In humans, ingested parasites from the gastrointestinal system enter the liver via the portal vein. Rarely, hepatic hydatid cysts can rupture into the portal vein and embolize to the lungs.
View Article and Find Full Text PDFBackground: Inpatients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are at increased risk for venous thromboembolism (VTE); however, the prophylaxis for VTE is largely underused in China. Identifying high-risk patients requiring thromboprophylaxis is critical to reduce the mortality and morbidity associated with VTE. This study aimed to evaluate and compare the validities of the Padua Prediction Score and Caprini risk assessment model (RAM) in predicting the risk of VTE in inpatients with AECOPD in China.
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