MOF-derived nitrogen, sulfur, cobalt, and copper co-doped graphite felt for high-efficiency vanadium redox flow battery electrodes.

The low electrocatalytic activity of pristine graphite felt (GF) electrodes towards V(II)/V(III) and V(IV)/V(V) redox couples poses a significant challenge in vanadium redox flow batteries (VRFBs). Here, Metal-organic frameworks (MOFs) containing Cu, Co, N, and S are proposed as precursors for the construction of metal and nonmetal co-doped GF electrodes, which exhibit enhanced catalytic activity compared to pristine GF electrodes. The synergistic effect of the metal and nonmetal components results in the N,S/Cu,Co@GF electrode exhibiting increased hydrophilicity, electrochemical reactivity, and reversibility.

Spatial Proteomic Profiling of Colorectal Cancer Revealed Its Tumor Microenvironment Heterogeneity.

Colorectal cancer is a predominant malignancy with a second mortality worldwide. Despite its prevalence, therapeutic options remain constrained and surgical operation is still the most useful therapy. In this regard, a comprehensive spatially resolved quantitative proteome atlas was constructed to explore the functional proteomic landscape of colorectal cancer.

High-performance bismuth vanadate photoanodes cocatalyzed with nitrogen, sulphur co-doped ferrocobalt-metal organic frameworks thin layer for photoelectrochemical water splitting.

In this study, we prepare a highly efficient BiVO photoanode co-catalyzed with an ultrathin layer of N, S co-doped FeCo-Metal Organic Frameworks (MOFs) for photoelectrochemical water splitting. The introduction of N and S into FeCo-MOFs enhances electron and mass transfer, exposing more catalytic active sites and significantly improving the catalytic performance of N, S co-doped FeCo-based MOFs in water oxidation. The optimized BiVO/NS-FeCo-MOFs photoanode exhibits impressive results, with a photocurrent density of 5.

Three dimensional nickel foam carried sea urchin-like copper-cobalt-cerium cathode for enhanced tetracycline wastewater purification in photocatalytic fuel cell.

Photocatalytic fuel cells (PFCs) regarded as a potential sustainable technique, have been broadly reported. In this work, the carbon quantum dot-loaded TiO photoanode and sea urchin-like CuCoCe ternary metal oxide cathode materials are successfully synthesized and used to construct PFC systems for efficient tetracycline (TC) degradation (45 mg/L) and simultaneous electricity generation. The results demonstrate that the CQDs-modified TiO photoanode has improved absorption intensity in both the UV and visible regions, and the photocurrent density at 1.

Flower ball cathode assembled from Cu doped CoS/NiS ultrathin nanosheets in a photocatalytic fuel cell for efficient photoelectrochemical rifampicin purification and simultaneous electricity generation based on a CuO QDs/TiO/WO photoanode.

Herein, an efficient CuO QDs/TiO/WO photoanode and a Cu doped CoS/NiS cathode were successfully synthesized. The optimized CuO QDs/TiO/WO photoanode achieved a photocurrent density of 1.93 mA cm at 1.

Expression Profiles, Prognosis, and ceRNA Regulation of SRY-Related HMG-Box Genes in Stomach Adenocarcinoma.

Aberrant expression of the SRY-related HMG-box (SOX) genes contributes to tumor development and progression. This research aimed to identify the regulation of the SOX genes in stomach adenocarcinoma (STAD). Expression profiles downloaded from The Cancer Genome Atlas (TCGA) were conducted to analyze the expression and function of the SOX genes.

Distinct Urinary Metabolic Biomarkers of Human Colorectal Cancer.

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with high mortality rate due to its poor diagnosis in the early stage. Here, we report a urinary metabolomic study on a cohort of CRC patients ( =67) and healthy controls ( =21) using ultraperformance liquid chromatography triple quadrupole mass spectrometry. Pathway analysis showed that a series of pathways that belong to amino acid metabolism, carbohydrate metabolism, and lipid metabolism were dysregulated, for instance the glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, glyoxylate and dicarboxylate metabolism, glycolysis, and TCA cycle.

High-performance BiVO photoanodes cocatalyzed with bilayer metal-organic frameworks for photoelectrochemical application.

In this work, we modified a BiVO photoanode with bilayer Fe-MOF and Ni-MOF as cocatalysts for the first time and obtained a highly efficient BiVO composite photoanode whose photocurrent density was increased by 2.7 times. The optimized BiVO/Fe-MOF/Ni-MOF photoanode demonstrated a photocurrent density of 1.

Biomimetic Nanocarriers Guide Extracellular ATP Homeostasis to Remodel Energy Metabolism for Activating Innate and Adaptive Immunity System.

Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have shown promise in reinvigorating antitumor immunity. However, approved small molecule immunomodulators often suffer from ineffective response rates and severe off-target toxicity. ATP occupies a crucial role in energy metabolism of components that form the tumor microenvironment (TME) and influences cancer immunosurveillance.

Huge gastric plexiform fibromyxoma presenting as pyemia by rupture of tumor: A case report.

Background: Plexiform fibromyxoma (PF) is a rare mesenchymal tumor, with limited case reports worldwide. Common clinical symptoms are abdominal discomfort and bleeding signs, which frequently present slow-onset in reported cases. Herein, we report a case of gastric PF presenting as acute onset and with pyemia accom-panying tumor rupture.

Tumor-derived exosomes co-delivering aggregation-induced emission luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I photodynamic therapy.

Although promising, the efficiency of aggregation-induced emission luminogens (AIEgens)-based photodynamic therapy (PDT) is limited by cellular glutathione (GSH). GSH is not a terminal reducing agent but it can be oxidized and subsequently reduced to its original state by reductases to further participate in antioxidant activity. It is therefore imperative to control GSH for effectively inducing oxidation within tumor cells.

Enhanced reactive oxygen species via in situ producing HO and synchronous catalytic conversion at stable modified copper foam cathode for efficient high-concentration organic wastewater treatment and simultaneous electricity generation.

Efficient high-concentration organics degradation (including 2-CP, phenol, and tetracycline) and simultaneous electricity generation were achieved via in situ producing HO and synchronous catalytic conversion to more reactive oxygen species at stable modified copper foam cathode. The cathode was synthesized using the one-pot electrodeposition method and was used to in-situ generate HO through the two-electron reduction of oxygen. The produced HO was then catalytically converted into ·OH and ·O simultaneously.

Integrative multiplatform-based molecular profiling of human colorectal cancer reveals proteogenomic alterations underlying mitochondrial inactivation.

Mitochondria play leading roles in initiation and progression of colorectal cancer (CRC). Proteogenomic analyses of mitochondria of CRC tumor cells would likely enhance our understanding of CRC pathogenesis and reveal new independent prognostic factors and treatment targets. However, comprehensive investigations focused on mitochondria of CRC patients are lacking.

Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients.

Background: The identification of novel functional biomarkers is essential for recognizing high-risk patients, predicting recurrence, and searching for appropriate treatment. However, no prognostic biomarker has been applied for colorectal cancer (CRC) in the clinic.

Methods: Integrated with transcriptomic data from public databases, multi-omics examinations were conducted to search prognostic biomarkers for CRC.

Delivery of manganese carbonyl to the tumor microenvironment using Tumor-Derived exosomes for cancer gas therapy and low dose radiotherapy.

The development of novel radiosensitizer with high selectivity and controllability is highly desirable. CO gas could cause damage to mitochondria and thus enhance RT effect. Controlled delivery of CO in tumor is important both to achieve high-efficiency of CO gas therapy and to decrease the risk of CO poisoning.

Modification of Black Phosphorus Nanosheets with a Ni-Containing Carbon Layer as Efficient and Stable Hydrogen Production Electrocatalysts.

Few-layered black phosphorus (FP) has recently attracted extensive research in the energy and materials fields. However, because of its chemically unstable nature under ambient conditions, very positive hydrogen adsorption energy and less active sites, FP has not been an efficient catalyst for the hydrogen evolution reaction (HER). In this research, we have developed a new strategy to overcome FP's drawbacks and to make it an active and stable HER catalyst.

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor.

The restriction of a tumor's energy supply is proven to be an effective means of treatment. Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard. However, hypoxia, which is implicated in tumor growth, has been found to mediate resistance to this type of tumor starvation.

Label-free and self-assembled fluorescent DNA nanopompom for determination of miRNA-21.

A label-free fluorescence method based on self-assembled DNA nanopompom has been developed for miRNA-21 detection. In the presence of miRNA-21, three DNA hairpin probes with split G-quadruplex assemble the DNA nanopompom. Based on the isothermal toehold-mediated DNA strand displacement reaction, the target miRNA can be catalytically recycled and trigger three DNA hairpin probes to self-assemble the DNA nanopompom and release the G-quadruplex.

Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy.

The development of novel photosensitizing agents with aggregation-induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor-exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth.

A lysosome specific, acidic-pH activated, near-infrared Bodipy fluorescent probe for noninvasive, long-term, in vivo tumor imaging.

Long-term, in vivo, fluorescent cell tracking probes are useful for understanding complex cellular processes including tissue regeneration, communication, development, invasion, and cancer metastasis. A near-infrared fluorescent, water-soluble probe is particularly important for studying these biological events and processes. Herein, a lysosome specific, near-infrared Bodipy probe with increased fluorescent intensity in the acidic, lysosome environment is reported.

Efficient organic pollutants conversion and electricity generation for carbonate-containing wastewater based on carbonate radical reactions initiated by BiVO-Au/PVC system.

In this paper, we propose an efficient simultaneous refractory organics degradation and electricity generation method for carbonate-containing wastewater based on carbonate radical reactions initiated by a BiVO-Au/PVC (PVC: photovoltaic cell) system. In the system, nanoporous BiVO film and Au modified PVC were used as photoanode and photocathode, respectively. HCO was used as the electrolyte.

Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors.

To investigate the autophagy-related gene (ATG) expression and the associated noncoding RNAs (ncRNA) and transcription factors (TF) in digestive system tumors (DST). We systematically investigated the ATG expression in DST by weighted gene correlation network analysis, crosstalk connection, functional analysis and Pivot analysis. ATGs were clustered into six modules with co-expression in DST.

Local staging of rectal cancer using fused high resolution diffusion weighted imaging and modified MR rectography.

Rectal cancer (RC) is a common malignant tumor with high mortality. MR imaging plays an important role in treatment decision making of RC. Unfortunately, the contents (gas and feces) in the rectum often induce artifacts and thus negatively affect the depicting and staging of RC.

Circulating tumor DNA sequencing for colorectal cancers: A comparative analysis of colon cancer and rectal cancer data.

Background: Circulating tumor DNA (ctDNA) has been recognized as a promising biomarker for colorectal cancer (CRC) early diagnosis and postoperative monitoring. However, we hypothesize that the clinical value of ctDNA sequencing may differ for colon cancer (CC) and rectal cancer (RC).

Methods: Forty-three patients with primary CRC were prospectively enrolled.

MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1.

Background: While microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, the role of miR-107 remains unknown. We evaluated its role and explored the underlying mechanism.

Materials & Methods: MTT, wound-healing, transwell migration and transwell invasion assays were performed to evaluate the role of miR-107 in SW629 cell proliferation, migration and invasion.