Methodological study of directed differentiation of pluripotent stem cells into corneal endothelial cells.

Background: Corneal transplantation is the most effective clinical treatment for irreversible corneal endothelial decompensation. However, while visual rehabilitation can be achieved by corneal transplantation, transplant rejection, poor postoperative visual acuity, and lack of suitable donor tissue are currently the greatest obstacles to corneal transplantation. As a result, endothelial cell-based therapy has emerged as an alternative to corneal transplantation treatment.

Clinical study of customized aspherical intraocular lens implants.

Aim: To compare if there is an improvement in visual functions with age-related cataracts between patients receiving a aspherical intraocular lens (IOL) based on corneal wavefront aberration and patients randomly assigned lenses.

Methods: A total of 124 eyes of 124 patients with age-related cataracts were placed in experimental group and a group receiving randomly assigned (RA) lenses. The experimental group was undergone Pentacam corneal spherical aberration measurement before surgery; the targeted range for residual total spherical aberration after surgery was set to 0-0.

Evaluation of the consistency of total spherical aberration before and after aspherical intraocular lens implantation.

Purpose: To analyze the consistency between preoperatively estimated and postoperatively measured total spherical aberration and to evaluate the feasibility of personalized selection of an aspherical intraocular lens (IOL) based on the corneal spherical aberration measured by the Scheimpflug photography system (Pentacam).

Methods: A total of 47 patients (82 eyes) with age-related cataract received a comprehensive ophthalmologic examination. Corneal spherical aberration was measured by using the Scheimpflug photography system.