Publications by authors named "Lieve Op De Beeck"
Objective: Pharmacological doses of estrogens or testosterone are used to limit the final height of girls or boys with constitutional tall stature but the mechanism behind this growth inhibition is still debated. We therefore studied the changes in the circulating components of the insulin-like growth factor (IGF) system during high dose sex steroid therapy.
Design And Methods: Twenty three girls and twenty boys with constitutional tall stature were treated with 100 microg ethinylestradiol per day or 250 mg testosterone ester every 14 days respectively.
Objective: This study was designed to assess whether children and adolescents with type 1 diabetes have early echocardiographic signs of subclinical cardiac dysfunction and whether sex, state of metabolic control, and diabetes duration are of influence.
Research Design And Methods: Systolic and diastolic blood pressure in supine and upright positions and echocardiographic parameters, including tissue Doppler measurements of the septal mitral annulus, were evaluated in 80 children and adolescents with stable type 1 diabetes and 52 age- and sex-matched control subjects. A possible correlation was examined for age, sex, HbA(1c), and diabetes duration with univariate and multivariate regression analysis.
Objectives: To evaluate whether QT interval, QT interval corrected for heart rate (QTc), and QTc dispersion changes are already present in children and adolescents with diabetes.
Study Design: QT interval, QTc, and QTc dispersion were measured on a 12-lead surface electrocardiogram in 60 children and adolescents with stable type 1 diabetes and in 63 sex- and age-matched control subjects. Differences were evaluated by using the Kolmogorov-Smirnov Z test.
Article Synopsis
- The study aimed to assess how high-dose estrogen treatment affects various IGF components in girls with constitutional tall stature.
- Blood samples were collected before and after 3 months of estrogen treatment to analyze changes in IGF-I, IGF-II, and IGFBPs.
- Results showed that total IGF-I decreased during treatment but returned to previous levels after stopping, indicating that estrogen influences IGF levels primarily through a reduction in synthesis rather than changes in IGFBP levels.