Publications by authors named "Lien Xuan Truong"
Objectives: The objective of this study was to investigate the potential epidemiological impact of viral load (VL) monitoring and its cost-effectiveness in Vietnam, where transmitted HIV drug resistance (TDR) prevalence has increased from <5% to 5%-15% in the past decade.
Methods: Using a population-based mathematical model driven by data from Vietnam, we simulated scenarios of various combinations of VL testing coverage, VL thresholds for second-line ART initiation and availability of HIV drug-resistance tests. We assessed the cost per disability-adjusted life year (DALY) averted for each scenario.
Article Synopsis
- - The study aimed to assess the prevalence of pretreatment drug resistance (PDR) to first-line antiretroviral drugs among HIV patients starting treatment in Vietnam, with data collected from 2009 to 2010 across various clinics.
- - Out of 490 participants with detectable viral loads, 3.5% exhibited drug-resistance mutations, with a higher prevalence found in individuals who injected drugs (4.0%) compared to those with sexually acquired HIV (1.4%).
- - The findings suggest that PDR to first-line antiretroviral drugs is low in Vietnam, indicating that first-line treatments are likely effective, though ongoing monitoring and prevention strategies are necessary to maintain this low resistance rate.
We have previously associated high natural killer (NK)-cell activity and protection against HIV-1 infection in Vietnamese exposed uninfected intravascular drug users (EUs). Considering that activating and inhibitory signals sensed by NK-cell receptors regulate NK-cell activation, we performed phenotypic and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) transcript analyses of the NK-cell receptor (NKR) repertoire in 25 EUs, 19 HIV(+) intravenous drug users, and 26 uninfected blood donors. Although NK-cell activation was not linked to a unique NKR repertoire in EUs, various patterns consistent with NK-cell activation were detected in EUs: high KIR3DS1/KIR3DL1 ratio associated with down-regulated KIR3DL1 transcript levels, KIR2DL3(+) low-affinity receptor expansion associated to group HLA-C1 ligand in 2DS2(-)/2DL2(-) EUs, enhanced NKG2C/NKG2A ratio, and increased CD69 expression.
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