Publications by authors named "Lien Dorme"
Article Synopsis
- Patient-reported outcomes (PROs) in cancer trials are important for understanding treatment effects on symptoms and quality of life, but there is no agreed-upon method for analyzing them, which complicates result interpretation.
- A consortium was created to establish recommendations for PRO analysis, focusing on research objectives, appropriate statistical methods, and how to handle missing data.
- This Policy Review outlines these recommendations based on comprehensive literature reviews and collaboration among international experts, and it also discusses future developments in this area.
Although patient-reported outcomes (PROs), such as health-related quality of life, are important endpoints in randomised controlled trials (RCTs), there is little consensus about the analysis, interpretation, and reporting of these data. We did a systematic review to assess the variability, quality, and standards of PRO data analyses in advanced breast cancer RCTs. We searched PubMed for English language articles published in peer-reviewed journals between Jan 1, 2001, and Oct 30, 2017.
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